Results 301 to 310 of about 1,538,508 (356)
Some of the next articles are maybe not open access.
2015
Identifying a compound or class of compounds that has biological activity at a particular biomolecular target is a necessary first step toward an eventual clinical candidate. In the vast majority of programs, however, many additional related compounds, possibly hundreds or even thousands, will need to be prepared and tested before a suitable molecule ...
openaire +2 more sources
Identifying a compound or class of compounds that has biological activity at a particular biomolecular target is a necessary first step toward an eventual clinical candidate. In the vast majority of programs, however, many additional related compounds, possibly hundreds or even thousands, will need to be prepared and tested before a suitable molecule ...
openaire +2 more sources
Oxadiazoles in Medicinal Chemistry
Journal of Medicinal Chemistry, 2012Oxadiazoles are five-membered heteroaromatic rings containing two carbons, two nitrogens, and one oxygen atom, and they exist in different regioisomeric forms. Oxadiazoles are frequently occurring motifs in druglike molecules, and they are often used with the intention of being bioisosteric replacements for ester and amide functionalities.
Alleyn T. Plowright +4 more
openaire +2 more sources
Automation in Medicinal Chemistry
ChemInform, 2004AbstractFor Abstract see ChemInform Abstract in Full Text.
openaire +4 more sources
Applications of Deuterium in Medicinal Chemistry.
Journal of Medicinal Chemistry, 2019The use of deuteration in medicinal chemistry has exploded in the past years, and the FDA has recently approved the first deuterium-labeled drug. Precision deuteration goes beyond the pure and simple amelioration of the pharmacokinetic parameters of a ...
T. Pirali +3 more
semanticscholar +1 more source
Recent Applications of Azo Dyes: A Paradigm Shift from Medicinal Chemistry to Biomedical Sciences.
Mini-Reviews in Medical Chemistry, 2020Azo molecules are one of the fascinating organic molecular architectures with azo bond (-N=N-). Since the last century, the bright colored azo molecules are used as dyes for printing, food, paper, cosmetic laser, electronics, optics, material sciences ...
M. N. Khan, D. Parmar, D. Das
semanticscholar +1 more source
Fluorine in Medicinal Chemistry
ChemBioChem, 2004AbstractFluorinated compounds are synthesized in pharmaceutical research on a routine basis and many marketed compounds contain fluorine. The present review summarizes some of the most frequently employed strategies for using fluorine substituents in medicinal chemistry. Quite often, fluorine is introduced to improve the metabolic stability by blocking
Ulrike Obst-Sander +7 more
openaire +3 more sources
Venomics in Medicinal Chemistry [PDF]
Future Medicinal Chemistry, 2014 Venom peptides mainly target ion channels, but also GPCRs, transporters and enzymes with high affinity and exquisite selectivity. The intermediate size of these peptidic toxins and their proteinaceous nature make them particularly suited formedicinal chemistry.
openaire +2 more sources
Drug Discovery Today, 2006
With the advent of high throughput technologies in biological screening in the 1980s, providing sufficient numbers of small molecules for screening became a bottleneck in the drug discovery process. Combinatorial chemistry was the first attempt by chemists to address this issue. However, since its first applications, combinatorial chemistry has evolved
Marcus Koppitz, Knut Eis
openaire +3 more sources
With the advent of high throughput technologies in biological screening in the 1980s, providing sufficient numbers of small molecules for screening became a bottleneck in the drug discovery process. Combinatorial chemistry was the first attempt by chemists to address this issue. However, since its first applications, combinatorial chemistry has evolved
Marcus Koppitz, Knut Eis
openaire +3 more sources
Proteomics in Medicinal Chemistry
Mini-Reviews in Medicinal Chemistry, 2006Proteomics is becoming an important research area for studying protein expression patterns induced by different external stimuli. An important aspect of proteomics is to identify and quantify proteins. Many new technologies and techniques have been developed in this field and have been applied to various aspects of drug discovery.
openaire +3 more sources
Macromolecular Chemistry and Medicine
Angewandte Chemie International Edition in English, 1970AbstractMacromolecular substances are used in medicine both as materials and as reagents. In the former category polymers serve as replacements for soft tissue, as cardiovascular and orthopedic implants, and as adhesives. When employed as reagents, macromolecules interact with living tissue and play an active part in bodily repair processes.
openaire +3 more sources