Results 81 to 90 of about 390,146 (300)

Medicinal Chemistry of Annonaceous Acetogenins: Design, Synthesis, and Biological Evaluation of Novel Analogues [PDF]

, 2009
Naoto Kojima, Tetsuaki Tanaka
openalex   +1 more source

Azadirachta indica (neem): An important medicinal plant: A literature review of its chemistry, biological activities, role in COVID-19 management and economic importance [PDF]

, 2023
Umar Muhammad Faisal, Muhammad Sahil Saifi, Md. Kaish, Maryamu Ibrahim, Shiwani Shiwani, Said Suleiman Kwakuri, Muhammad Arif   +6 more
openalex   +1 more source

Allo-network drugs: Extension of the allosteric drug concept to protein-protein interaction and signaling networks [PDF]

, 2013
Allosteric drugs are usually more specific and have fewer side effects than orthosteric drugs targeting the same protein. Here, we overview the current knowledge on allosteric signal transmission from the network point of view, and show that most ...
Csermely, Péter, Nussinov, Ruth, Szilágyi, András   +2 more
core   +2 more sources

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Open access and medicinal chemistry

Chemistry Central Journal, 2007
Chemistry Central is a new open access website for chemists publishing peer-reviewed research in chemistry from a range of open access journals.
Swain Chris
doaj   +1 more source

クリックケミストリー　二　ヨル　オリゴ　カクサンジョウ　デノ　ヒテンネンガタ　エンキ　ノ　コウチク　ト　ソノ　ブッセイ　ヒョウカ [PDF]

this is the author’s version of a work that was accepted for publication in Bioorganic & Medicinal Chemistry Letters. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality ...
ナカハラ, モトイ, 中原, 基
core   +1 more source

Novel 1,3-thiazolidin-4-one derivatives as promising anti-Candida agents endowed with anti-oxidant and chelating properties [PDF]

, 2016
Pursuing our recent outcomes regarding the antifungal activity of N-substituted 1,3-thiazolidin-4-ones, we synthesized thirty-six new derivatives introducing aliphatic, cycloaliphatic and heteroaromatic moieties at N1-hydrazine connected with C2 position
Abdurrahman, Aktumsek, Adriano, Mollica, Bizzarri, Bruna, Chimenti, Paola, DE MONTE, Celeste, Emanuela, Mari, Gokhan, Zengin, Rivanera, Daniela, Secci, Daniela, Simone, Carradori, Zicari, Alessandra   +10 more
core   +1 more source

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

Molecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh, Nikola Tom, Anna Schrøder Lassen, Helene Brasch Lind Petersen, Ulrik Kristoffer Stoltze, Karin Wadt, Kjeld Schmiegelow, Matteo Tiberti, Elena Papaleo   +8 more
wiley   +1 more source

Division of Medicinal Chemistry: Frontiers in Medicinal Chemistry

CHIMIA, 2010
Swiss Chemical Society
doaj   +6 more sources

How Efficient Is My (Medicinal) Chemistry? [PDF]

, 2016
Jean Jacques Vanden Eynde
openalex   +1 more source