Results 41 to 50 of about 211,052 (211)

From Valeriana officinalis to cancer therapy: the success of a bio-sourced compound

Biotechnologie, Agronomie, Société et Environnement, 2016
Introduction. Over the centuries, bio-sourced compounds isolated from plants, insects and microorganisms have been a potent source of drugs for the treatment of human diseases. Literature.
Hamaidia, M., Barez, PY., Carpentier, A., Lebecque, S., Miazek, K., Paul, A., Sriramareddy, SN., Staumont, B., Danthine, S., Deleu, M., Frederich, M., De Pauw, E., Delaplace, P., Delvigne, F., Goffin, D., Ongena, M., Duysinx, B., Louis, R., Cosse, JP., Willems, L.   +19 more
doaj  

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Guidance on Safety assessment of botanicals and botanical preparations intended for use as ingredients in food supplements

EFSA Journal, 2009
In this opinion, EFSA's Scientific Committee provides guidance on the scientific data needed to carry out a safety assessments of a botanical or a botanical preparation.
European Food Safety Authority, EFSA Scientific Committee   +1 more
doaj   +1 more source

Benzylisoquinoline Alkaloids Biosynthesis in Sacred Lotus

Molecules, 2018
Sacred lotus (Nelumbo nucifera Gaertn.) is an ancient aquatic plant used throughout Asia for its nutritional and medicinal properties. Benzylisoquinoline alkaloids (BIAs), mostly within the aporphine and bisbenzylisoquinoline structural categories, are ...
Ivette M. Menéndez-Perdomo, Peter J. Facchini   +1 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Adaptive phenylpropanoid and flavonoid biosynthesis pathways of Agriophyllum squarrosum on the Qinghai-Xizang Plateau

Medicinal Plant Biology
With climate change and human activities, the Qinghai-Xizang Plateau (QXP) faces increasing risk of desertification. High-altitude desert plants exhibit remarkable resilience, making them ideal for restoring desertified lands on the QXP.
Chaoju Qian, Xiaoyue Yin, Xia Yan, Xingke Fan, Shanshan Zhou, Tingzhou Fang, Yuxiao Chang, Xiao-Fei Ma   +7 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source