Results 51 to 60 of about 211,052 (211)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Curcumin, an active component of turmeric: biological activities, nutritional aspects, immunological, bioavailability, and human health benefits - a comprehensive review

Frontiers in Immunology
Curcumin (1,7-bis-(4-hydroxy-3-methoxyphenyl)-hepta-1,6-diene-3,5-dione) is a naturally occurring polyphenol molecule. It is lipophilic and has demonstrated in vitro and in vivo therapeutic effects through multiple pathways.
Mohamed T. El-Saadony, Ahmed M. Saad, Dina Mostafa Mohammed, Samar Sami Alkafaas, Soumya Ghosh, Shaimaa H. Negm, Heba M. Salem, Mohamed A. Fahmy, Walid F. A. Mosa, Essam H. Ibrahim, Synan F. AbuQamar, Khaled A. El-Tarabily   +11 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

First genome assembly and annotation of Sanghuangporus weigelae uncovers its medicinal functions, metabolic pathways, and evolution

Frontiers in Cellular and Infection Microbiology
Sanghuangporus, also known as “Sanghuang” in China, is a well-known genus of traditional Chinese medicinal macrofungi. To make more effective use of Sanghuangporus resources, we completed the first genome assembly and annotation of a monokaryon strain of
Can Jin, Jin-Xin Ma, Hao Wang, Lu-Xin Tang, Yi-Fan Ye, Xin Li, Jing Si   +6 more
doaj   +1 more source

Potential Underexploited Vegetable Crops of Tamil Nadu with Emphasis on Nutritional and Medicinal Value [PDF]

Madras Agricultural Journal
Underutilized vegetable crops represent a vital yet often neglected segment of agro-biodiversity, offering considerable potential to enhance nutritional security, sustainable agriculture, and resilience to climate change. Tamil Nadu, with its varied agro-
Ajay Raja. A, Praneetha. S, Lokesh. R, Dinesh. D   +3 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Potential Medicinal Fungi from Freshwater Environments as Resources of Bioactive Compounds

Journal of Fungi
Owing to their nutritional, culinary, and nutraceutical, mushrooms are worldwide consumed and appreciated. Moreover, many of these mushrooms are also known as medicinal mushrooms since they possess several pharmacological properties attributable to a ...
Ilenia Cicero, Giulia Mirabile, Giuseppe Venturella   +2 more
doaj   +1 more source

A review on post-harvest technology of an underutilized vegetable bitter tomato (Solanum aethiopicum L cv. gilo) of Northeastern region of India [PDF]

BIO Web of Conferences
Northeastern region of India is endowed with variety of local vegetables that are highly nutritious and health-promoting. One of which is Solanum aethiopicum L which has a bountiful source of nutrients and bioactive chemicals.
Jamir Satemmenla, Devi Kshetrimayum Sonia, Ningombam Elizabeth, Verma Anamika   +3 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source