Results 91 to 100 of about 26,997,198 (419)
FEBS Letters, EarlyView.Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma +8 more
wiley +1 more source
Sarcoma treatment in the era of molecular medicine
EMBO Molecular Medicine, 2020 Sarcomas are heterogeneous and clinically challenging soft tissue and bone cancers. Although constituting only 1% of all human malignancies, sarcomas represent the second most common type of solid tumors in children and adolescents and comprise an ...
T. G. Grünewald +41 more
semanticscholar +1 more source
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source
Women Physicians and Promotion in Academic Medicine.
New England Journal of Medicine, 2020 BACKGROUND In 2000, a landmark study showed that women who graduated from U.S. medical schools from 1979 through 1997 were less likely than their male counterparts to be promoted to upper faculty ranks in academic medical centers.
K. Richter +8 more
semanticscholar +1 more source
Ensuring sample quality for biomarker discovery studies - Use of ict tools to trace biosample life-cycle [PDF]
, 2015 The growing demand of personalized medicine marked the transition from an empirical medicine to a molecular one, aimed at predicting safer and more effective medical treatment for every patient, while minimizing adverse effects.
Alessandroni, Jhessica +10 more
core
Identification of novel small molecule inhibitors of ETS transcription factors
FEBS Letters, EarlyView.ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla +9 more
wiley +1 more source
Human gene and disease associations for clinical‐genomics and precision medicine research
Clinical and Translational Medicine, 2020 We are entering the era of personalized medicine in which an individual's genetic makeup will eventually determine how a doctor can tailor his or her therapy.
Zeeshan Ahmed +3 more
semanticscholar +1 more source
Medicinal Chemistry: Where Are All the Women? [PDF]
ACS Medicinal Chemistry Letters, 2017 A review of multiple parameters including membership in professional organizations, corresponding authorship of medicinal chemistry journal articles, and representation in professional and leadership positions reveals that the percentage of women who participate in professional medicinal chemistry activities is less than 20%.
Donna M. Huryn +2 more
openaire +3 more sources
Getting off the carousel : Exploring the wicked problem of curriculum reform [PDF]
, 2017 Acknowledgements The authors wish to thank all participants in this study. Our thanks to the School of Medicine where this study was undertaken for supporting LH’s doctoral research program.
Cleland, Jennifer +2 more
core +1 more source
BMC Infectious DiseasesBackground Visceral leishmaniasis (VL) is a neglected tropical disease primarily affecting Brazil, East Africa, and India, with India accounting for 18% of the global burden. While VL typically presents with systemic symptoms like fever, weight loss, and
Karthick Kumar Vaitheeswaran +12 more
doaj +1 more source