Results 131 to 140 of about 2,161,810 (255)

Recent Advancements in Reducing the Off-Target Effect of CRISPR-Cas9 Genome Editing

open access: yesBiologics: Targets & Therapy
Misganaw Asmamaw Mengstie,1 Muluken Teshome Azezew,2 Tadesse Asmamaw Dejenie,3 Assefa Agegnehu Teshome,4 Fitalew Tadele Admasu,1 Awgichew Behaile Teklemariam,1 Anemut Tilahun Mulu,1 Melaku Mekonnen Agidew,1 Dagnew Getnet Adugna,5 Habtamu Geremew,6 ...
Asmamaw Mengstie M   +10 more
doaj  

Enhancing Interprofessional Education: Insights from Students at the College of Medicine and Health Sciences at the University of Rwanda. [PDF]

open access: yesRwanda J Med Health Sci
Uwimana P   +9 more
europepmc   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Evaluating Interprofessional Education Readiness and Perceptions Among Health Professions Students

open access: yesAdvances in Medical Education and Practice
Nouf Sulaiman Alharbi,1– 3 Nourah Mohammed Alenazi,4 Alaa Althubaiti,2,5 Reem Alkahtani,2,3,6 Seema Nasser,2,3,7 Marwh Gassim Aldriwesh2,3,8 1Department of Medical Education, College of Medicine, King Saud bin Abdulaziz University for Health Sciences ...
Alharbi NS   +5 more
doaj  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Home - About - Disclaimer - Privacy