Results 81 to 90 of about 3,590,044 (385)

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source

Awareness Towards Corona Virus Disease (COVID-19) and Its Prevention Methods in Selected Sites in Wolaita Zone, Southern Ethiopia: A Quick, Exploratory, Operational Assessment

Risk Management and Healthcare Policy, 2020
Eskinder Wolka, 1 Zewde Zema, 2 Melkamu Worku, 3 Kassahun Tafesse, 1 Antehun Alemayehu, 4 Kassahun Tekle Takiso, 5 Hailu Chare, 2 Lolemo Kelbiso 6 1Wolaita Sodo University College of Health Sciences and Medicine, School of Public Health, Sodo, Ethiopia;
Wolka E, Zema Z, Worku M, Tafesse K, Anjulo AA, Takiso KT, Chare H, Kelbiso L   +7 more
doaj  

All Health Is Global Health, All Medicine Is Social Medicine: Integrating the Social Sciences Into the Preclinical Curriculum.

Academic medicine : journal of the Association of American Medical Colleges, 2016
As physicians work to achieve optimal health outcomes for their patients, they often struggle to address the issues that arise outside the clinic. Social, economic, and political factors influence patients' burden of disease, access to treatment, and ...
J. Kasper, J. Greene, P. Farmer, David S. Jones   +3 more
semanticscholar   +1 more source

Factors associated with self-care activities among adults in the United Kingdom: a systematic review [PDF]

, 2009
Background: The Government has promoted self-care. Our aim was to review evidence about who uses self-tests and other self-care activities (over-the-counter medicine, private sector,complementary and alternative medicine (CAM), home blood pressure ...
A Furnham, A Furnham, A Furnham, A Furnham, A Furnham, A Furnham, A Furnham, A Ryan, Aliki Taylor, Angela Ryan, B Boardman, C Featherstone, C Featherstone, C McGrath, C Mulvaney, C Ong, C Ong, C Paterson, C Propper, C Propper, C Vincent, C Vincent, CP Bradley, D King, Department of Health, Department of Health, E Ernst, F Cappuccio, FMC Sharples, FP Cappuccio, G Urquhart, G Wadlow, GJ Andrews, GJ Andrews, H Freymann, H MacPherson, J Murray, J Richardson, JC McElnay, K Payne, K Thomas, KA Vickers, KJ Thomas, M Emslie, M Wazaify, MJ Emslie, NJ Gray, P Trinder, RA Harrison, RJ McManus, S Kayne, S Reid, S Wilson, Sheila Greenfield, SM Greenfield, Sue Wilson, T Besley, T Cartwright, T Porteous   +58 more
core   +4 more sources

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

Brucella NyxA and NyxB dimerization enhances effector function during infection

FEBS Letters, EarlyView.
Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre, Arthur Louche, Francine C. A. Gérard, Laurent Terradot, Suzana P. Salcedo   +4 more
wiley   +1 more source

Community Level of COVID-19 Information Exposure and Influencing Factors in Northwest Ethiopia

Risk Management and Healthcare Policy, 2020
Animut Tagele Tamiru,1 Bayew Kelkay Rade,1 Eden Bishaw Taye,2 Zelalem Nigussie Azene,3 Mehari Woldemariam Merid,4 Atalay Goshu Muluneh,4 Getahun Molla Kassa,4 Melaku Kindie Yenit,4 Asefa Adimasu Taddese,4 Kassahum Alemu Gelaye,4 Demiss Mulatu Geberu,5 ...
Tamiru AT, Rade BK, Taye EB, Azene ZN, Merid MW, Muluneh AG, Molla GM, Yenit MK, Taddese AA, Gelaye KA, Geberu DM, Tilahun SY, Mekonnen HS, Azagew AW, Wubneh CA, Belay GM, Assimamaw NT, Agegnehu CD, Azale T, Andualem Z, Dagne H, Gashaye KT, Kabito GG, Mekonnen TH, Daba S, Azanaw J, Adane T, Alemayehu M   +27 more
doaj  

Assessment of Perceptions and Predictors Towards Consanguinity: A Cross-Sectional Study from Palestine

Journal of Multidisciplinary Healthcare, 2023
Mustafa Ghanim,1 Rami Mosleh,2 Anas Hamdan,3 Johnny Amer,4 Malik Alqub,4 Yazun Jarrar,5 Majdi Dwikat4 1Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine; 2Department of Pharmacy ...
Ghanim M, Mosleh R, Hamdan A, Amer J, Alqub M, Jarrar Y, Dwikat M   +6 more
doaj  

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

A coiled‐coil domain triggers oligomerization of MmpL10, the mycobacterial transporter of trehalose polyphleate precursor

FEBS Letters, EarlyView.
Most MmpLs transport lipids and glycolipids of the complex mycomembrane of mycobacteria. This study shows that MmpL10 from Mycobacterium smegmatis, the transporter of the trehalose polyphosphate precursor, harbors a coiled‐coil‐like extension. Biochemical and electron microscopy studies demonstrate that the coiled‐coil enables MmpL10 to trimerize.
Julie Couston, Jérôme Feuillard, Aurélie Ancelin, Joséphine Lai‐Kee‐Him, Konstantin Brodolin, Christian Chalut, Pontus Gourdon, Mickaël Blaise   +7 more
wiley   +1 more source