Results 71 to 80 of about 2,161,810 (255)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

COVID-19 Clinical Features and Recovery Time: Factors Affecting the Outcome [Letter]

open access: yesInfection and Drug Resistance, 2022
Abdul Moeed, Zunera Huda Department of Internal Medicine, Dow University of Health Sciences, Karachi, PakistanCorrespondence: Abdul Moeed, Department of Internal Medicine, Dow University of Health Sciences, Karachi, Pakistan, Tel +92-3061159372, Email ...
Moeed A, Huda Z
doaj  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Can routine hematological markers improve obesity risk stratification? A translational comment on El-Aghbary et al. [Response to Letter]

open access: yesDiabetes, Metabolic Syndrome and Obesity
Dekra Ali El-Aghbary,1 Rashad Ali Thabet,2 Mohammed AW Almorish,3 Khaled Mohammed Al-Sayaghi,4,5 Ahmed M E Elkhalifa6 1Department of Medical Microbiology and Immunology, Faculty of Medicine and Health Sciences, Sana’a University, Sana’
El-Aghbary DA   +4 more
doaj  

Role of Caspase-1 in the Pathogenesis of Inflammatory-Associated Chronic Noncommunicable Diseases

open access: yesJournal of Inflammation Research, 2020
Meseret Derbew Molla,1 Yonas Akalu,2 Zeleke Geto,3 Baye Dagnew,2 Birhanu Ayelign,4 Tewodros Shibabaw1 1Department of Biochemistry, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia; 2Department of Human ...
Molla MD   +5 more
doaj  

Learning health systems from an academic perspective: establishing a collaboratory within a school of medicine and health sciences. [PDF]

open access: yesMed Educ Online, 2021
McDonald PL   +5 more
europepmc   +1 more source

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