Results 41 to 50 of about 103,668 (195)

Durvalumab: an investigational anti-PD-L1 monoclonal antibody for the treatment of urothelial carcinoma. [PDF]

, 2018
Our expanding knowledge of immunotherapy for solid tumors has led to an explosion of clinical trials aimed at urothelial carcinoma. The primary strategy is centered on unleashing the immune system by releasing the inhibitory signals propagated by ...
Chamie, Karim, Crosetti, Anna M, Cummings, Amy L, Drakaki, Alexandra, Faiena, Izak, Pantuck, Allan J   +5 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Chinese bayberry (Morella rubra Lour.) seed improves DSS-induced inflammatory bowel disease by inhibiting inflammation and oxidative stress

Journal of Functional Foods
This study investigated the phytochemical characteristics and first explored its anti-inflammatory action related to IBD of Chinese bayberry (Morella rubra Lour.) seed.
Dan Long, Huan Zhao, Xia Wu, Lu Jin, Yuanquan Ran, Qiong Hu, Xiaoqing Zhao, Tian Zhang, Minyi Tian   +8 more
doaj   +1 more source

Multidimensional persistent homology is stable [PDF]

, 2009
Multidimensional persistence studies topological features of shapes by analyzing the lower level sets of vector-valued functions. The rank invariant completely determines the multidimensional analogue of persistent homology groups.
Cerri, Andrea, Di Fabio, Barbara, Ferri, Massimo, Frosini, Patrizio, Landi, Claudia   +4 more
core   +2 more sources

Phytochemical analysis and anticancer effect of Camellia oleifera bud ethanol extract in non-small cell lung cancer A549 cells

Frontiers in Pharmacology
Camellia oleifera is a medicine food homology plant widely cultivated in the Yangtze River Basin and southern China due to its camellia oil. Camellia oleifera bud and fruit exist simultaneously, and its bud is largely discarded as waste.
Jingming Niu, Xiaoyan Jia, Nian Yang, Nian Yang, Yuanquan Ran, Xia Wu, Furong Ding, Dongxin Tang, Minyi Tian, Minyi Tian, Minyi Tian   +10 more
doaj   +1 more source

The negative acute phase response of serum transthyretin following Streptococcus suis infection in the pig [PDF]

, 2005
Peer reviewedPublisher ...
Andresen, L O, Campbell, Fiona Margaret, Eckersall, P D, Heegaard, P M H, Sorensen, N S, Waterston, M   +5 more
core   +4 more sources

Advances in the Identification Methods of Food-Medicine Homologous Herbal Materials

Foods
As a key component of both traditional medicine and modern healthcare, Food–Medicine Homologous Herbal Materials have attracted considerable attention in recent years. However, issues related to the quality and authenticity of medicinal materials on the market often arise, not only compromising their efficacy but also presenting potential risks to ...
Yuying Jiang, Shilei Wei, Hongyi Ge, Yuan Zhang, Heng Wang, Xixi Wen, Chunyan Guo, Shun Wang, Zhikun Chen, Peng Li   +9 more
openaire   +3 more sources

Therapeutic effect of dihydroartemisinin on Alzheimer’s disease model mice with senile macular degeneration

European Journal of Medical Research
Objectives This study focuses on the preventive and therapeutic effects of Dihydroartemisinin (DHA) on Alzheimer’s disease (AD) model mice and the effects of DHA and donepezil on amyloid β-protein deposition and autophagy in nerve cells.
Gao Han, Gong Xuewu, Zhang Meng, Wang Yuejing, Wang Yuchun, Zhang Keshuang, Yao Hongbo   +6 more
doaj   +1 more source

Yinshan Zhengyao: exploring the power of food and inheriting healthy thoughts

Food & Medicine Homology
Yinshan Zhengyao stands as a classic in health preservation, gathering the principles of the homology of food and medicine. The book is divided into three volumes, emphasizing the significance of food in the prevention and treatment of chronic diseases ...
Hui Niu, Aruhan, Seesregdorj Surenjidiin, Li-Ming Zhang, Chun-Hong Zhang, Min-Hui Li   +5 more
doaj   +1 more source

Biotechnological applications of functional metagenomics in the food and pharmaceutical industries [PDF]

, 2015
peer-reviewedMicroorganisms are found throughout nature, thriving in a vast range of environmental conditions. The majority of them are unculturable or difficult to culture by traditional methods.
Alvarez-Ordonez, Avelino, Cotter, Paul D., Coughlan, Laura M., Hill, Colin   +3 more
core   +1 more source