Results 111 to 120 of about 15,498,020 (343)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

A Saga-In-Progress: Challenges and Milestones on Our Way Toward the Nordic Core Values and Principles of Family Medicine/General Practice. [PDF]

Front Med (Lausanne), 2021
Sigurdsson JA, Beich A, Stavdal A.
europepmc   +1 more source

Ophthalmology and general medicine [PDF]

Postgraduate Medical Journal, 2000
This ophthalmological perspective of general medicine attempts to deal with the more common situations encountered clinically in general ophthalmic practice. Some priority has been given to the clinical usefulness of data. A comprehensive review would involve a wide range of rare conditions and has not been attempted.
openaire   +2 more sources

Trends in sexually transmitted infections in general practice 1990-2000: population based study using data from the UK general practice research database [PDF]

, 2006
Objective: To describe the contribution of primary care to the diagnosis and management of sexually transmitted infections in the United Kingdom, 1990-2000, in the context of increasing incidence of infections in genitourinary medicine clinics ...
Brook, M.G., Cassell, J.A., Hayward, A.C., Hughes, G., Islam, A., Johnson, A.M., Kinghorn, G.R., Majeed, A., Mercer, C.H., Petersen, I., Ross, J.D., Simms, I., Stephenson, J.M., Sutcliffe, L.   +13 more
core  

A Classification Method for General Medicine Physicians to Advance Field Research in Japan

International Journal of General Medicine
Masaki Tago,1 Risa Hirata,1 Kiyoshi Shikino,2,3 Takashi Watari,4 Hiromizu Takahashi,5 Tomoyo Nishi,1 Yosuke Sasaki,6 Taro Shimizu7 1Department of General Medicine, Saga University Hospital, Saga, Japan; 2Department of Community-Oriented Medical Education,
Tago M, Hirata R, Shikino K, Watari T, Takahashi H, Nishi T, Sasaki Y, Shimizu T   +7 more
doaj  

Buried Bumper Syndrome: The Paradox of Rapid Nutritional Recovery After Percutaneous Endoscopic Gastrostomy

Clinical Case Reports
Rapid weight gain after PEG placement can precipitate Buried Bumper Syndrome (BBS) by increasing abdominal wall thickness, even in nonobese patients. Regular reassessment of external bumper position and tube length is essential in patients expected to ...
Satoshi Inaba, Hayato Fukui, Norifumi Ohnishi, Toshifumi Tsuji, Masayuki Oda, Atsushi Kawashima   +5 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Real opinions on general medicine residency programs in Japan: Perspectives from medical students, residents, and young academic generalists

Journal of General and Family Medicine, 2023
Kosuke Ishizuka, Hiroyuki Nagano, Taiju Miyagami, Tatsushi Toyooka, Sunsuke Ohara, Erica Ogami   +5 more
doaj   +1 more source

The Characteristics of General Medicine Thesis in Kermanshah University of Medical Sciences during Five Years Periods

آموزش پزشکی, 2018
BACKGROUND AND OBJECTIVE: Doing and writing the qualified thesis could be considered as the onset of the research proceeding and formation of academic identity of students.
Mohammad rasoul Khazaee, Ali Karimi, Mohammad Bagher Heydari, Mozaffar Khazaei   +3 more
doaj  

Managing Primary Immunodeficiency Immunoglobulin Replacement Therapy‐Related Adverse Events With Recombinant Human C1 Esterase Inhibitor Prophylaxis: A Case Report

Clinical Case Reports
Immunoglobulin replacement therapy (IRT) for primary immunodeficiency reduces infection risk and subsequent complications and can be lifesaving. However, IRT can cause severe systemic adverse events (AEs) that may limit adequate dosing.
Douglas H. Jones, Heidi Memmott
doaj   +1 more source