Results 71 to 80 of about 3,738,036 (312)

Availability and stock-out duration of essential medicines in Shegaw Motta general hospital and Motta Health Centre, North West Ethiopia

open access: gold, 2022
Bereket Bahiru Tefera   +6 more
openalex   +2 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

A Classification Method for General Medicine Physicians to Advance Field Research in Japan

open access: yesInternational Journal of General Medicine
Masaki Tago,1 Risa Hirata,1 Kiyoshi Shikino,2,3 Takashi Watari,4 Hiromizu Takahashi,5 Tomoyo Nishi,1 Yosuke Sasaki,6 Taro Shimizu7 1Department of General Medicine, Saga University Hospital, Saga, Japan; 2Department of Community-Oriented Medical Education,
Tago M   +7 more
doaj  

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

open access: yesMolecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He   +8 more
wiley   +1 more source

Editorial: Methods in general cardiovascular medicine

open access: yesFrontiers in Cardiovascular Medicine, 2023
Serafino Fazio   +4 more
doaj   +1 more source

The Characteristics of General Medicine Thesis in Kermanshah University of Medical Sciences during Five Years Periods

open access: yesآموزش پزشکی, 2018
BACKGROUND AND OBJECTIVE: Doing and writing the qualified thesis could be considered as the onset of the research proceeding and formation of academic identity of students.
Mohammad rasoul Khazaee   +3 more
doaj  

Buried Bumper Syndrome: The Paradox of Rapid Nutritional Recovery After Percutaneous Endoscopic Gastrostomy

open access: yesClinical Case Reports
Rapid weight gain after PEG placement can precipitate Buried Bumper Syndrome (BBS) by increasing abdominal wall thickness, even in nonobese patients. Regular reassessment of external bumper position and tube length is essential in patients expected to ...
Satoshi Inaba   +5 more
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

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