Results 71 to 80 of about 15,498,020 (343)

Mapping the evolution of mitochondrial complex I through structural variation

open access: yesFEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin   +2 more
wiley   +1 more source

Bad Medicine: Generation X [PDF]

open access: yesBritish Journal of General Practice, 2019
I am part of Generation X. A title that makes us sound like sad wannabe mysterious nerd types with no imagination. We are the forgotten generation. Not the narcissist baby-boomers intent on a life of indulgent self discovery, nor the ever-angry and entitled ‘TAKE ME SERIOUSLY’ millennials, who will never be as special as the parents told them they were.
openaire   +2 more sources

Biopiracy versus one-world medicine – from colonial relicts to global collaborative concepts [PDF]

open access: yes, 2019
Background: Practices of biopiracy to use genetic resources and indigenous knowledge by Western companies without benefit-sharing of those, who generated the traditional knowledge, can be understood as form of neocolonialism.Hypothesis: : The One-World ...
Abdelfatah, Sara   +40 more
core   +2 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

open access: yesFEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi   +5 more
wiley   +1 more source

Why Compulsory Family Medicine for General Practice?

open access: yesSouth African Family Practice, 2003
No abstract available.
Jannie Hugo
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

A personalist-phenomenological model of general resurrection in light of current science and medicine [PDF]

open access: yes, 2018
I have argued that the central Christian doctrine of general resurrection (with particular reference to the Pauline corpus) can and should be understood in a scientifically and philosophically informed context, and have proposed a personalist ...
Danielyan, Edgar
core  

EVIDENCE-BASED MEDICINE – I. GENERAL PRINCIPLES

open access: yesZdravniški Vestnik, 2003
Background. Evidence-based medicine is a method that helps physicians find and critically evaluate evidences from the medical literature, and apply the evidences in clinical decision-making. In clinical practice the method supplements core medical skills,
Angela Čuk
doaj  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Longer Lives?: Understanding the Human Life Extension Possibilities [PDF]

open access: yes, 2017
Over the last few years, ethical and social issues related to life extension have gathered much attention among biologists, medical doctors and philosophers.
Garcia-Barranquero, Pablo
core  

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