Results 171 to 180 of about 4,187,936 (295)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

iPSCs chondrogenic differentiation for personalized regenerative medicine: a literature review. [PDF]

Stem Cell Res Ther
Ali EAM, Smaida R, Meyer M, Ou W, Li Z, Han Z, Benkirane-Jessel N, Gottenberg JE, Hua G.   +8 more
europepmc   +1 more source

An Analysis of the Top-cited Articles in Emergency Medicine Education Literature. [PDF]

West J Emerg Med, 2017
Munzer BW, Love J, Shipman BL, Byrne B, Cico SJ, Furlong R, Khandelwal S, Santen SA.   +7 more
europepmc   +1 more source

[In search of medicine in literature. An introduction to the field of literature and medicine].

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1996
In the last two decades increasing academic interest has been shown for the field of literature and medicine. This article introduces the field, and outlines different approaches. Teaching literature in medical education may help physicians and medical students to develop skills and insight of importance for good understanding and practice of their ...
openaire   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Evidence-Based Practice for the Use of pH Indicator Paper Strip in Oral Medicine: A Literature Review. [PDF]

Cureus
Shamsi-Basha B, Bernard-Garbati R, Mortier E, Grasland A, Lachgar K, Alantar A.   +5 more
europepmc   +1 more source

Mood disorders and complementary and alternative medicine: a literature review. [PDF]

Neuropsychiatr Dis Treat, 2013
Qureshi NA, Al-Bedah AM.
europepmc   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Patient compliance based on genetic medicine: a literature review. [PDF]

J Community Genet, 2014
Schneider KI, Schmidtke J.
europepmc   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source