Results 51 to 60 of about 242,017 (306)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Freeze Out Process with In-Medium Nucleon Mass [PDF]

open access: yes, 2006
We investigate the kinetic freeze out scenario of a nucleon gas through a finite layer. The in-medium mass modification of nucleons and it's impact on the freeze out process is studied.
Csernai, Laszlo P.   +4 more
core   +2 more sources

Phase-field analysis of quenching and partitioning in a polycrystalline Fe-C system under constrained-carbon equilibrium condition

open access: yes, 2018
Mechanical properties of steels are significantly enhanced by retained austenite. Particularly, it has been shown that a recently developed heat-treatment technique called Quenching and Partitioning (Q\&P) stabilises austenite effectively. In the present
Amos, P G Kubendran   +4 more
core   +1 more source

Directed sub-wavelength imaging using a layered metal-dielectric system [PDF]

open access: yes, 2006
We examine some of the optical properties of a metamaterial consisting of thin layers of alternating metal and dielectric. We can model this material as a homogeneous effective medium with anisotropic dielectric permittivity.
Pendry, J B, Tsai, D P, Wood, B
core   +2 more sources

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

open access: yesMolecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta   +10 more
wiley   +1 more source

Preparation of high-strength and high-ductility medium Mn steel with chemistry heterogeneous via a two-step intercritical annealing process

open access: yesJournal of Materials Research and Technology
Recently, the retained austenite (RA) with chemically heterogeneous has attracted great attention in medium Mn steel. In this work, we designed a two-step intercritical annealing (TIA) heat treatment process to prepare high-strength medium Mn steel with ...
Geng Tian   +5 more
doaj   +1 more source

Primordial Non-Gaussianity and Reionization

open access: yes, 2013
The statistical properties of the primordial perturbations contain clues about the origins of those fluctuations. Although the Planck collaboration has recently obtained tight constraints on primordial non-gaussianity from cosmic microwave background ...
Adshead, Peter   +3 more
core   +1 more source

Effect of warm to hot rolling on microstructure, texture and mechanical properties of an advanced medium-Mn Steel [PDF]

open access: yes, 2019
The deformation microstructures and mechanical properties were studied in a medium-Mn austenitic steel subjected to warm-to-hot ...
Belyakov, A.   +5 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Short-term effects of Mn2+ on elongation growth and H+ -extrusion in Zea mays L. coleoptile segments

open access: yesActa Societatis Botanicorum Poloniae, 2014
The effect of 10-2-10-6 M Mn+2 on the growth and acidification of the incubation medium by Zea mays L. coleoptile segments was studied. It is shown that 10-5M manganese stimulated growth (in comparison to a control without Mn+2) while concentrations from
Waldemar Karcz   +2 more
doaj   +1 more source

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