Results 71 to 80 of about 242,017 (306)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Proceedings, 2019 The phenomenon of jet quenching indicates that partons lose energy as they traverse the hot dense medium. By restricting a trigger jet in azimuth relative to the event plane, we are given another tool, which allows us to study the path length dependence ...
Joel Mazer
doaj +1 more source
Strengthening mechanisms in vanadium-microalloyed medium-Mn steels
Materials Today CommunicationsPeer ...
Zvavamwe, Felisters +4 more
openaire +2 more sources
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
, 2020 The present work applies an intercritical annealing process on a room-temperature quenching and partitioning (RT Q&P) medium Mn steel. It is found that the intercritical annealing maintains the amount of austenite while improves its mechanical stability.
He, BB, Huang, MX, Pan, S
core +2 more sources
Microstructure and mechanical properties of Mo-Nb microalloyed medium Manganese trip Steel by cyclic quenching [PDF]
, 2019 A novel cyclic quenching (CQ) and austenite reverse transformation (ART) was proposed for a Fe-0.25C-3.98Mn-1.22Al-0.20Si-0.19Mo-0.03Nb (wt.%) Mo-Nb microalloyed medium-Mn TRIP steel to improve strength and ductility.
Liu, Chunquan +2 more
core +2 more sources
Effect of Prestrain on Hydrogen-Induced Delayed Cracking for Medium Mn Steels [PDF]
, 2020 Medium Mn steels are a class of the new-generation ultra-high-strength materials used in automotives. However, despite excellent ductility, they may suffer from delayed cracking and thus cause serious concerns.
Li, JX +6 more
core +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
The Sun's Journey Through the Local Interstellar Medium: The PaleoLISM and Paleoheliosphere
, 2006 Over the recent past, the galactic environment of the Sun has differed substantially from today. Sometime within the past ~130,000 years, and possibly as recent as ~56,000 years ago, the Sun entered the tenuous tepid partially ionized interstellar ...
Frisch, P. C., Slavin, J. D.
core +2 more sources