Results 41 to 50 of about 243,034 (306)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

REDEFINIÇÃO DA CENTRALIDADE URBANA EM CIDADES MÉDIAS / Redefinition of the urban centrality in medium-sized cities [PDF]

Sociedade & Natureza, 2008
The presented article realizes one effort reflective whose main objective is to analyze the processes ofdecentralization and recentralization in medium-sized cities that, conjugated, result in new centralitiesand the redefinition of the urban centrality ...
Gilberto Alves de Oliveira Júnior
doaj  

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Problems and solutions on land reservation system of small and medium-sized cities in China

, 2008
Based on the analysis of the basic principal of land reservation system of small and medium-sized cities, this paper gives detailed discuss on many problems which exist during the process of land reservation system, such as unclear function position of ...
Dong, Wei, Feng, Bing, Liu, Chunlu, Shi, Yimei   +3 more
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Medium-Sized Cities and the Dynamics of Creative Services [PDF]

This paper examines the development of “creative” services (research, information, art etc.), located in medium-sized areas. Insofar as urban dynamics lead to extend the advanced services outside metropolises, particular attention is given to issues ...
Claude LACOUR (GREThA-GRES), Sylvette PUISSANT (GREThA-GRES)   +1 more
core   +3 more sources

Effective per capita municipal expenditures correlated with population changes in small and medium-sized cities in Japan

Journal of Urban Management
In recent years, urban policy-makers have been urged to adopt the development of urban policies for shrinking cities from an urban management perspective.
Haruka Kato
doaj   +1 more source

Smart City Development in Nordic Medium-sized Municipalities

Nordic and Baltic Journal of Information & Communications Technologies, 2021
The Nordic countries stand out as digital frontrunners in Europe as well as in a global perspective. However, smart city development in medium-sized municipalities in the Nordic region is less researched than large Nordic cities. Hence, the purpose of this paper is to study how medium- sized municipalities in the Nordic region are organized for smart ...
Lindtvedt, Ida Cathrine Ringdal, Frøhaug, Ragnhild Skirdal, Nesse, Per Jonny   +2 more
openaire   +2 more sources

Can medium-sized cities become Creative Cities? Discussing the cases of three Central and Western European cities [PDF]

, 2018
This paper aims to explore the concept of Creative City from the points of view of three medium-sized cities in Central and Western Europe: Birmingham (UK), Leipzig (Germany) and Poznań (Poland).
Chapain, Caroline, Lange, Bastian, Stachowiak, Krzysztof   +2 more
core   +1 more source

Les réseaux de villes en France : quels acteurs? Quelles finalités? Quel avenir? [PDF]

, 1998
En cette fin de siècle, la France n’échappe pas aux diktats de la mondialisation des marchés pas plus qu’à celui de l’intégration européenne. Le nouveau contexte exacerbe la compétition à toutes les échelles géographiques mais interpelle particulièrement
Bruneau, Pierre
core   +1 more source