Results 51 to 60 of about 243,034 (306)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
A Multi-Scalar Analysis of European Cities [PDF]
Medium-sized European cities are facing serious problems in terms of the exploitation of local resources (land, water, air). In this article, we observe existing links between sustainable development and cities’ economic and structural features. We adopt
Enrico Giovannetti, Francesco Pagliacci
core +3 more sources
Walk Score from 2D to 3D—Walkability for the Elderly in Two Medium-Sized Cities in Germany
ISPRS International Journal of Geo-Information, 2023 In this article, we describe the design of a method for measuring walkability and its application in two medium-sized cities in Germany. The method modifies the established Walk Score with regard to the needs of older people.
Markus Schaffert +4 more
doaj +1 more source
Tipologia socioambiental de cidades médias no Brasil: aportes para um desenvolvimento urbano sustentável [PDF]
, 2015 The global urbanization of the territories, which is an important ongoing human ecological phenomenon, and whose environmental impacts have local, regional and global levels, has the remarkable property of a sharp growth of small and intermediate cities,
Albertín, R.M. +4 more
core +2 more sources
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
As metrópoles do interior do Nordeste: a caracterização de um tipo metropolitano regional
Cadernos MetrópoleResumo O objetivo deste trabalho é apresentar como as configurações dão suporte à constituição do que se denominou Regiões Metropolitanas no Interior do Nordeste (RMINEs), buscando a caracterização de um tipo metropolitano regional.
Ana Paula Campos Gurgel
doaj +1 more source
Agent organisation in land development: high-speed train in medium-sized cities [PDF]
, 2007 Si queremos evaluar el grado de desarrollo local que aporta el Tren de Alta Velocidad (TAV) en una ciudad es primordial observar la capacidad de los actores del territorio de organizarse para aprovechar sus recursos endógenos.
Feliu Torrent, Jaume
core +3 more sources
FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley +1 more source