Results 31 to 40 of about 70,093 (231)

Enhancement of CRISPR-Cas9 induced precise gene editing by targeting histone H2A-K15 ubiquitination

BMC Biotechnology, 2020
Background Precise genetic modifications are preferred products of CRISPR-Cas9 mediated gene editing in mammalian cells but require the repair of induced double-strand breaks (DSB) through homology directed repair (HDR).
Sanum Bashir, Tu Dang, Jana Rossius, Johanna Wolf, Ralf Kühn   +4 more
doaj   +1 more source

Improved team communication in endoscopic procedures by digital enhanced telecommunication during the COVID-19 pandemic

Endoscopy International Open, 2022
Background and study aims Unbiased communication is crucial for excellent teamwork in high-quality endoscopy. Personal protective equipment (PPE) (FFP-masks and face-shields) worn by endoscopists that are ubiquitous in the current COVID-19 pandemic ...
Niklas Sturm, Lukas Perkhofer, Lucas Schulte, Benjamin Mayer, Thomas Seufferlein, Martin Wagner, Benjamin M. Walter   +6 more
doaj   +1 more source

Querschnittevaluation des Medizinischen Curriculums München (MeCuM) mit Hilfe des Progress Tests Medizin (PTM) [Using the Progress Test Medizin (PTM) for evaluation of the Medical Curriculum Munich (MeCuM)]

GMS Zeitschrift für Medizinische Ausbildung, 2010
[english] Aims: The Medical Curriculum Munich (MeCuM) has been implemented since 2004 and was completely established in 2007. In this study the clinical part of MeCuM was evaluated with respect to retention of the knowledge in internal medicine (learning
Reincke, Martin, Nouns, Zineb, Holzer, Matthias, Schmidmaier, Ralf, Angstwurm, Matthias, Fischer, Martin R.   +5 more
doaj   +1 more source

«Smarter Medicine»: 5 Interventionen, die in der ambulanten allgemeinen inneren Medizin vermieden werden sollten [PDF]

, 2014
Seit 2012 befasst sich die Schweizerische Gesellschaft für Allgemeine Innere Medizin mit der Problematik der Überdiagnostik und Überversorgung in der Medizin.
Zeller, A, Gaspoz, J M, Meier, C, Neuner-Jehle, S, Cornuz, J, Selby, K, Perrier, A, Rodondi, N   +7 more
core   +1 more source

Regenerative Therapy of Type 1 Diabetes Mellitus: From Pancreatic Islet Transplantation to Mesenchymal Stem Cells

Stem Cells International, 2016
Type 1 diabetes is an autoimmune disease resulting in the permanent destruction of pancreatic islets. Islet transplantation to portal vein provides an approach to compensate for loss of insulin producing cells.
Nadine E. Rekittke, Meidjie Ang, Divya Rawat, Rahul Khatri, Thomas Linn   +4 more
doaj   +1 more source

Glomage: A Multimodal Platform for High‐Content Morphological and RNA Profiling of Glomeruli in Zebrafish and Mouse Models

Advanced Science, EarlyView.
Understanding how glomeruli, the kidney's filtration units, function in intact tissue remains challenging. Glomage enables rapid 3D imaging and quantitative analysis of entire glomeruli from zebrafish larvae and mice. This approach allows scalable cell quantification and detection of structural changes, advancing kidney disease research and ...
Maximilian Schindler, Tim Lange, Sophia‐Marie Bach, Soeren S. Lienkamp, Nicole Endlich   +4 more
wiley   +1 more source

Stem Cell Differentiation Disperses Transcriptional Clusters via a Conserved Surface‐Condensate Trajectory

Advanced Science, EarlyView.
Stem cell differentiation follows a conserved surface condensate trajectory: H3K27ac super enhancers nucleate large RNA polymerase II clusters that grow and unfold before transcriptional activity disperses them. This work reveals how biophysical forces at enhancer surfaces dynamically build and dismantle stem cell transcription hubs, reshaping cell ...
Tim Klingberg, Irina Wachter, Agnieszka Pancholi, Matthias Akyel, Yomna Gohar, Priya Kumar, Ana Miguel Fernandes, Yuzhi Bao, Alica Schmidt‐Heydt, Marcel Piepers, Alicia Günthel, Marcel Sobucki, Elisa Kämmer, Süheyla Eroğlu‐Kayıkçı, Stephan Allgeier, Sylvia Erhardt, Vasily Zaburdaev, Carmelo Ferrai, Lennart Hilbert   +18 more
wiley   +1 more source

Interdigitale Aptamer‐Sensoren mit komplementären Messkanälen zur schnellen Detektion kleiner Moleküle in Biofluiden

Angewandte Chemie, EarlyView.
Ein elektrochemischer Aptamer‐Sensorchip nutzt Interdigitalelektroden mit selektiver Monoschicht‐Funktionalisierung, um Dopamin und Cortisol mittels robuster komplementärer „Signal‐Off/On“‐Antworten zu detektieren. Diese Dual‐Channel‐Signalumwandlung ermöglicht eine schnelle Detektion innerhalb von 5–30 min bei geringen Probenvolumina in künstlicher ...
Senyao Wang, Ali Elmorsy, Defne Tüzün, Lilly Schmidt, Sebastian Freko, Lukas Hiendlmeier, Chen Wang, Alonso Ingar Romero, George Al Boustani, Hu Peng, Berna Özkale, Nako Nakatsuka, Bernhard Wolfrum   +12 more
wiley   +1 more source

Normolipemic dysbetalipoproteinemia and hyperlipoproteinemia type III in subjects homozygous for a rare genetic apolipoprotein E variant (apoE1).

Journal of Lipid Research, 1990
A family with three heterozygote and two homozygote carriers of the rare apolipoprotein E1 isoform was detected by isoelectric focusing.
A Steinmetz, N Assefbarkhi, C Eltze, K Ehlenz, H Funke, A Pies, G Assmann, H Kaffarnik   +7 more
doaj   +1 more source

Real‐world characteristics and treatment of cardiac transthyretin amyloidosis: A multicentre, observational study

ESC Heart Failure, Volume 12, Issue 2, Page 1203-1216, April 2025.
The 366 patients diagnosed with transthyretin amyloidosis cardiomyopathy (ATTR‐CM) were analyzed regarding their clinical characteristics in the first year after approval of tafamidis 61 mg for ATTR‐CM in Germany. Nearly two‐thirds of the patients were in an advanced disease stage and 64% met the key criteria of the “Transthyretin Amyloidosis ...
Richard J. Nies, Svenja Ney, Ingrid Kindermann, Yvonne Bewarder, Angela Zimmer, Fabian Knebel, Katrin Hahn, Sebastian Spethmann, Peter Luedike, Lars Michel, Tienush Rassaf, Maria Papathanasiou, Stefan Störk, Vladimir Cejka, Amin Polzin, Fabian Voss, Malte Kelm, Bernhard Unsöld, Christine Meindl, Michael Paulus, Ali Yilmaz, Bishwas Chamling, Caroline Morbach, Roman Pfister   +23 more
wiley   +1 more source