Results 31 to 40 of about 27,270 (200)

Enhancement of CRISPR-Cas9 induced precise gene editing by targeting histone H2A-K15 ubiquitination

BMC Biotechnology, 2020
Background Precise genetic modifications are preferred products of CRISPR-Cas9 mediated gene editing in mammalian cells but require the repair of induced double-strand breaks (DSB) through homology directed repair (HDR).
Sanum Bashir, Tu Dang, Jana Rossius, Johanna Wolf, Ralf Kühn   +4 more
doaj   +1 more source

Untersuchung von Anti‐Glykan‐Antikörpern und Erforschung ihres medizinischen Potenzials mithilfe synthetischer Glykane

Angewandte Chemie, EarlyView.
Anti‐Glykan‐Antikörper spielen sowohl bei Gesundheit als auch bei Krankheit eine wesentliche Rolle. Der Zugang zu neuartigen Glykanstrukturen ermöglicht Fortschritte bei der Antikörpercharakterisierung für die Entdeckung von Biomarkern, die Antikörperentwicklung und das Impfstoffdesign.
Fabienne Weber, Aina Valenti, Jiří Ledvinka, Oren Moscovitz, Peter H. Seeberger   +4 more
wiley   +1 more source

Psychiatry in transition: an assessment in the context of societal change. [PDF]

Ann Gen Psychiatry
Aims To explore how global challenges such as climate change, artificial intelligence (AI), and migration intersect with generational change among psychiatric trainees and reshape specialist training.
Wedmann FM, Albasini F, Davidson R, Mayr A, Conca A.   +4 more
europepmc   +2 more sources

Real‐world characteristics and treatment of cardiac transthyretin amyloidosis: A multicentre, observational study

ESC Heart Failure, Volume 12, Issue 2, Page 1203-1216, April 2025.
The 366 patients diagnosed with transthyretin amyloidosis cardiomyopathy (ATTR‐CM) were analyzed regarding their clinical characteristics in the first year after approval of tafamidis 61 mg for ATTR‐CM in Germany. Nearly two‐thirds of the patients were in an advanced disease stage and 64% met the key criteria of the “Transthyretin Amyloidosis ...
Richard J. Nies, Svenja Ney, Ingrid Kindermann, Yvonne Bewarder, Angela Zimmer, Fabian Knebel, Katrin Hahn, Sebastian Spethmann, Peter Luedike, Lars Michel, Tienush Rassaf, Maria Papathanasiou, Stefan Störk, Vladimir Cejka, Amin Polzin, Fabian Voss, Malte Kelm, Bernhard Unsöld, Christine Meindl, Michael Paulus, Ali Yilmaz, Bishwas Chamling, Caroline Morbach, Roman Pfister   +23 more
wiley   +1 more source

Lassen Sie uns über das Scheitern bzw. den Umgang mit Misserfolgen sprechen: Ein Interview mit Dietrich Rebholz-Schuhmann

Bibliothek
Die Zentralbibliothek Medizin wurde 2015 nach einer Evaluierung aus der Leibniz-Gemeinschaft ausgeschlossen. Der Leiter der Zentralbibliothek Medizin, Prof. Dr. Dietrich Rebholz-Schuhmann, spricht über die anschließende Neuausrichtung der ZB MED nach dem
Rebholz-Schumann Dietrich
doaj   +1 more source

Notch signaling drives development of Barrett’s metaplasia from Dclk1-positive epithelial tuft cells in the murine gastric mucosa

Scientific Reports, 2021
Barrett’s esophagus (BE) is a precursor to esophageal adenocarcinoma (EAC), but its cellular origin and mechanism of neoplastic progression remain unresolved.
Bettina Kunze, Moritz Middelhoff, H. Carlo Maurer, Tatiana Agibalova, Akanksha Anand, Anne-Marie Bührer, Hsin-Yu Fang, Theresa Baumeister, Katja Steiger, Julia Strangmann, Roland M. Schmid, Timothy C. Wang, Michael Quante   +12 more
doaj   +1 more source

Submental Approach Robotic‐Assisted Neck Dissection (SARAND) for Minimally Invasive Bilateral Neck Dissection: A Feasibility Cadaver Dissection Study

Head &Neck, EarlyView.
ABSTRACT Background Following promising initial results of the robotic‐assisted extended “Sistrunk” approach (RESA) that uses a submental incision to hypopharyngeal and laryngeal tumors, bypassing the base of tongue, we report its further development: submental approach robotic‐assisted neck dissection (SARAND), intended to enable bilateral neck ...
Bartosz P. Wojtera, Karma Lambercy, Avinash Beharry, Ka Hei Suen, Markus Rheinwald, Christian Simon   +5 more
wiley   +1 more source

Mitteilungen aus der Arbeitsgemeinschaft Evidenzbasierte Medizin der AGMB

GMS Medizin – Bibliothek – Information
Die Arbeitsgemeinschaft Evidenzbasierte Medizin (AG-EBM) der Arbeitsgemeinschaft für Medizinisches Bibliothekswesen e. V. (AGMB) stellt seit ihrer Gründung im Jahr 2019 eine Plattform für Mitglieder der AGMB mit Hintergrund in der evidenzbasierten ...
von Gernler, Marc, Krause, Evamaria, Dressler, Corinna   +2 more
doaj   +1 more source

Normolipemic dysbetalipoproteinemia and hyperlipoproteinemia type III in subjects homozygous for a rare genetic apolipoprotein E variant (apoE1).

Journal of Lipid Research, 1990
A family with three heterozygote and two homozygote carriers of the rare apolipoprotein E1 isoform was detected by isoelectric focusing.
A Steinmetz, N Assefbarkhi, C Eltze, K Ehlenz, H Funke, A Pies, G Assmann, H Kaffarnik   +7 more
doaj   +1 more source

Molecular Tumor Boards in Malignant Melanoma: Uncovering Challenges and Opportunities in a Bicenter Retrospective Analysis in Germany

International Journal of Cancer, EarlyView.
Molecular tumor boards (MTB), interdisciplinary teams that use tumor genomic data to guide personalized treatment decisions, have emerged as a promising strategy in melanoma care, although their real‐world clinical impact remains uncertain. This retrospective study evaluated advanced melanoma patients to assess molecularly guided treatment ...
Glenn Geidel, Theresa Lowinus, Patrick Metzger, Rebecca Czurda, Vincent Schipperges, Ulrike Paul, Alessandra Rünger, Julian Kött, Isabel Heidrich, Saskia Lehr, Julia Kühn, Heiko Becker, Cornelius Miething, Martin Werner, Silke Laßmann, Justus Duyster, Tilman Brummer, Ronald Simon, Winfried Alsdorf, Maximilian Christopeit, Carsten Bokemeyer, Kilian Eyerich, Stefan W. Schneider, David Rafei, Melanie Börries, Frank Meiss, Christoffer Gebhardt   +26 more
wiley   +1 more source