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Medroxyprogesterone acetate in the management of cancer cachexia [PDF]
Expert Opinion on Pharmacotherapy, 2009 Medroxyprogesterone acetate (MPA) is a synthetic, orally active derivative of the natural steroid hormone progesterone, widely used in oncology both in the endocrine treatment of hormone-related cancers and as supportive therapy in the cachexia syndrome.The anticachectic mechanisms of medroxyprogesterone, beyond its endocrine activity, are described to
Giovanni Mantovani +2 more
exaly +5 more sources
Medroxyprogesterone acetate levels among Kenyan women using depot medroxyprogesterone acetate in the FEM-PrEP trial [PDF]
Contraception, 2016 ObjectiveTo describe medroxyprogesterone acetate (MPA) levels among Kenyan depot medroxyprogesterone acetate (DMPA) users in the FEM-PrEP HIV prevention trial, and to compare MPA levels between ARV for HIV prevention (treatment) and placebo groups.Study ...
Rebecca Callahan +2 more
exaly +2 more sources
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IMMUNOSUPPRESSION WITH MEDROXYPROGESTERONE ACETATE
Transplantation, 1968The immunosuppressive effects of MPA (medroxyprogesterone acetate) were tested in clinical studies with laboratory dogs and rabbits. The laboratory procedures employed in the studies are explained and results are tabulated and graphed. 2 microscopic photographs illustrate the observed effects.
J G, Turcotte +4 more
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Medroxyprogesterone acetate therapy in hirsutism
British Journal of Dermatology, 1985In a pilot study, 26 hirsute females were treated with medroxyprogesterone acetate (MPA). We used an ointment containing 0.2% MPA in 13 patients, subcutaneous injection of MPA into the hairy areas of the face in five patients and intramuscular injection of low doses of MPA in 13 patients, each for an average duration of 16 weeks.
J B, Schmidt, J, Huber, J, Spona
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Anaphylaxis From Medroxyprogesterone Acetate
Obstetrics & Gynecology, 2004More than 30 million women in more than 90 countries use depot medroxyprogesterone acetate as an injectable contraceptive agent, and it is thought to be very safe. However, it should be recognized that serious and potentially life-threatening adverse effects can occur.A 40-year-old para 2 went into anaphylactic shock after receiving 150 mg of depot ...
Daniel O, Selo-Ojeme +2 more
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A radioimmunoassay for serum medroxyprogesterone acetate
Journal of Steroid Biochemistry, 1978Abstract A radioimmunoassay for measuring medroxyprogesterone acetate in serum or plasma is described using an antiserum produced against the steroid-3-carboxymethyloxime coupled to bovine serum albumin. The method has adequate accuracy, precision and sensitivity and the reliability criteria of the method are compared with those of other ...
K, Shrimanker, B N, Saxena, K, Fotherby
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Medroxyprogesterone acetate in human serum
Journal of Steroid Biochemistry, 1981Medroxyprogesterone acetate (MPA) exists in blood both in the unconjugated and in the conjugated state. The mean concentration of MPA obtained after enzymic hydrolysis of the conjugated fraction was 82% of that in the unconjugated fraction. The conjugate appears to be mainly a glucuronide since solvolysis released only small amounts of MPA. Metabolites
M, Mathrubutham, K, Fotherby
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A TRIAL OF MEDROXYPROGESTERONE ACETATE IN ACROMEGALY
Clinical Endocrinology, 1972SUMMARYIn a series of acromegalic patients treated with radiotherapy to the pituitary high growth hormone levels were frequently found to persist after treatment. However, a late fall in the fasting plasma level of growth hormone was often seen. There was no evidence as to its cause.The use of medroxyprogesterone in a dose of 10 mg 6‐hourly over a ...
J S, Rake +3 more
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Depot-medroxyprogesterone acetate: an update
Archives of Gynecology and Obstetrics, 2008Depo-Provera is a contraceptive approved by the US Food and Drug Administration (FDA) since 1992 and used worldwide by more than 90 million women.Despite the fact that progestins are endogenous hormones that are secreted by the body, its excess might lead to detrimental health effects.
Sayed, Bakry +5 more
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