Results 171 to 180 of about 13,559 (225)
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Medroxyprogesterone acetate in human serum
Journal of Steroid Biochemistry, 1981Medroxyprogesterone acetate (MPA) exists in blood both in the unconjugated and in the conjugated state. The mean concentration of MPA obtained after enzymic hydrolysis of the conjugated fraction was 82% of that in the unconjugated fraction. The conjugate appears to be mainly a glucuronide since solvolysis released only small amounts of MPA. Metabolites
M, Mathrubutham, K, Fotherby
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A TRIAL OF MEDROXYPROGESTERONE ACETATE IN ACROMEGALY
Clinical Endocrinology, 1972SUMMARYIn a series of acromegalic patients treated with radiotherapy to the pituitary high growth hormone levels were frequently found to persist after treatment. However, a late fall in the fasting plasma level of growth hormone was often seen. There was no evidence as to its cause.The use of medroxyprogesterone in a dose of 10 mg 6‐hourly over a ...
J S, Rake +3 more
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Depot-medroxyprogesterone acetate: an update
Archives of Gynecology and Obstetrics, 2008Depo-Provera is a contraceptive approved by the US Food and Drug Administration (FDA) since 1992 and used worldwide by more than 90 million women.Despite the fact that progestins are endogenous hormones that are secreted by the body, its excess might lead to detrimental health effects.
Sayed, Bakry +5 more
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Medroxyprogesterone Acetate and Sleep Apnea
Psychiatry and Clinical Neurosciences, 1987Abstract: Seven patients with sleep apnea DOES and one with sleep apnea DIMS were treated with medroxyprogesterone acetate (MPA). The therapeutic effect was confirmed in most of them by polysomnographic recording. A marked increase of TST was observed in two patients whose AI and/or %SAT remarkably decreased.
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A potential mechanism in medroxyprogesterone acetate teratogenesis
Teratology, 1979AbstractMedroxyprogesterone acetate (MPA) has been shown to be teratogenic in rabbits but not in rats or mice (Andrew and Staples, 1977). Since normal steroid action appears to be mediated, in large part, through interaction with specific steroid receptors, we postulated that the species difference in teratogenicity might be due to a difference in the ...
G L, Kimmel, B S, Hartwell, F D, Andrew
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Depot Medroxyprogesterone Acetate
2020Depot medroxyprogesterone acetate (DMPA) is an injectable progestin-only contraceptive administered every 13 weeks. DMPA is an extremely effective contraceptive agent when used consistently. With typical use, approximately 6 out of 100 women will become pregnant in the first year of use, reflecting that some users do not return for repeat injections ...
Deanna C. McCullough +2 more
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The Response of the Bitch to Treatment with Medroxyprogesterone Acetate
Journal of Small Animal Practice, 1967Abstract— —Medroxyprogesterone acetate (M.A.P.) was administered to three groups of bitches as follows: Eighty‐six bitches received a total of 166 injections of M.A.P. to prevent or suppress oestrus. This procedure was entirely successful in 83 bitches (96.5 per cent) and partially successful or unsuccessful in the remaining 3 bitches.
A R, Withers, J C, Whitney
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GLC Determination of Medroxyprogesterone Acetate in Plasma
Journal of Pharmaceutical Sciences, 1974To study the absorption, metabolism, and excretion of medroxyprogesterone acetate in animals and man, a method was developed for measurement of the intact drug in plasma based on: (a) cyclohexane extraction of the specimen, (b) formation of the 3-enol heptafluorobutyrate ester, and (c) quantification via GLC using an electron-capture detector.
D G, Kaiser, R G, Carlson, K T, Kirton
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Toxicology of depot medroxyprogesterone acetate
Contraception, 1994Depo-Provera (depot-medroxyprogesterone acetate or DMPA), administered either subcutaneously or intramuscularly, has undergone a thorough toxicological evaluation in a number of animal species. DMPA has been tested in short- and long-term toxicity studies in rodents, rabbits, and monkeys.
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The Contraceptive Use of Depot Medroxyprogesterone Acetate
Clinical Obstetrics and Gynecology, 1995Depot medroxyprogesterone acetate (DMPA) was the first popular long-acting progestogen-only contraceptive and is used by more than nine million women worldwide. It is one of the most convenient and effective yet readily reversible methods of contraception.
M, Hickey, I, Fraser
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