Results 21 to 30 of about 10,362 (160)

Potential Deleterious Effects Following the First Dose of Medroxyprogesterone Acetate as a Contraceptive in Cats [PDF]

Journal of Applied Veterinary Sciences, 2023
The aim of the present work was to investigate the deleterious effects of the first dose of medroxyprogesterone acetate (MPA) on the female genital system of cats.
Ahmed Abdelgalil
doaj   +1 more source

Medroxyprogesterone acetate exacerbates glutamate excitotoxicity

Gynecological Endocrinology, 2006
We previously demonstrated that progesterone functions as a neuroprotective agent whereas medroxyprogesterone acetate (MPA; Provera) does not. Moreover, MPA antagonized the neuroprotective and neurotrophic outcomes induced by 17beta-estradiol (E2). Towards developing effective hormone therapies for protection against neurodegeneration, we sought to ...
Jon, Nilsen, Alison, Morales, Roberta Diaz, Brinton   +2 more
openaire   +2 more sources

Medroxyprogesterone acetate levels among Kenyan women using depot medroxyprogesterone acetate in the FEM-PrEP trial [PDF]

Contraception, 2016
To describe medroxyprogesterone acetate (MPA) levels among Kenyan depot medroxyprogesterone acetate (DMPA) users in the FEM-PrEP HIV prevention trial, and to compare MPA levels between ARV for HIV prevention (treatment) and placebo groups.We measured MPA in previously collected plasma samples from 63 Kenyan trial participants who used DMPA for one or ...
Nanda, Kavita, Callahan, Rebecca, Taylor, Douglas, Wang, Meng, Agot, Kawango, Jenkins, David, Van Damme, Lut, Dorflinger, Laneta   +7 more
openaire   +2 more sources

The effect of Vigna unguiculata on the estrogen receptor-α expression and the endometrial thickness in rats treated with depot medroxyprogesterone acetate (DMPA)

Healthcare in Low-resource Settings, 2023
Depot medroxyprogesterone acetate (DMPA) is a contraceptive method that prevents ovulation and reduces endometrial thickness. This study aimed to investigate the influence of Vigna unguiculata (VU) on estrogen receptor-α expression and endometrial ...
Rizki Fitrianingtyas, Indah Christiana, Ririn Handayani, Ernawati Anggraeni, Zaida Mauludiyah, Sholihatil Hidayati   +5 more
doaj   +1 more source

Bone mineral density changes during use of progestin-only contraceptives: a rapid review of recent evidenceAJOG Global Reports at a Glance

AJOG Global Reports
Objective: The purpose of this paper is to consolidate existing evidence and identify knowledge and research gaps on the bone health effects of progestin-only oral contraception, injectables, hormonal intrauterine devices, and implants.
Blake Erhardt-Ohren, MPH, Ndola Prata, MD, MSc, Scott Rosenblum, MS   +2 more
doaj   +1 more source

Hormonal Contraceptives: What if Exposed During Pregnancy?

Erciyes Medical Journal, 2019
Objective: Hormonal contraceptives are contraindicated in pregnancy. However, some women may become pregnant while using contraceptives to prevent pregnancy.
Duygun Altıntaş Aykan, Yusuf Ergün
doaj   +1 more source

IGFBP5 Restores Endometrial Receptivity and Rescues Implantation Failure in Polycystic Ovary Syndrome

Advanced Science, EarlyView.
Impaired endometrial receptivity contributes to the poor pregnancy outcomes in women with PCOS. The authors found that decreased endometrial IL‐22 levels and disrupted STAT3‐IGFBP5 signaling pathway contributed to impaired endometrial receptivity. Supplementation with IL‐22 or IGFBP5 exerts a protective effect on implantation failure in PCOS‐like mice,
Baoying Liao, Chuyu Yun, Hongying Shan, Yuqian Wang, Xiunan Chen, Weisi Lian, Tianliu Peng, Min Zhao, Xunsi Qin, Kailun Hu, Ping Zhou, Yue Wang, Yanli Pang, Rong Li   +13 more
wiley   +1 more source

The relationship between sex hormones, the vaginal microbiome and immunity in HIV-1 susceptibility in women

Disease Models & Mechanisms, 2018
The role of sex hormones in regulating immune responses in the female genital tract has been recognized for decades. More recently, it has become increasingly clear that sex hormones regulate susceptibility to sexually transmitted infections through ...
Jocelyn M. Wessels, Allison M. Felker, Haley A. Dupont, Charu Kaushic   +3 more
doaj   +1 more source

Advancing Maternal Health with Long‐Acting Therapeutics: Priorities, Efficacy and Safety Considerations, and Emerging Technologies

Clinical Pharmacology &Therapeutics, EarlyView.
Maternal health remains a critical global concern, particularly in underserved populations and in low‐ and middle‐income countries where access to safe and effective therapeutics is limited. Despite the use of medications by most women during pregnancy, the exclusion of pregnant and lactating women from clinical trials has resulted in significant data ...
Rachel K. Scott, Sharon Nachman, Ethel D. Weld, Rachel Daley, Shakir Atoyebi, Robert Bies, Catriona Waitt, Adeniyi Olagunju   +7 more
wiley   +1 more source

Efficacy of Different Progestins in Women With Advanced Endometriosis Undergoing Controlled Ovarian Hyperstimulation for in vitro Fertilization-A Single-Center Non-inferiority Randomized Controlled Trial

Frontiers in Endocrinology, 2020
Object: Is it possible to use different progestins cotreatment with human menopausal gonadotrophin (hMG) in women with advanced endometriosis but normal ovulation during controlled ovarian hyperstimulation (COH) in vitro fertilization (IVF)?
Haiyan Guo, Jianghui Li, Xi Shen, Yanyan Cong, Yun Wang, Ling Wu, Bin Li, Hongyuan Gao, Meng Ma, Wei Zhang, Xiaoyan Mao, Yonglun Fu, Qifeng Lyu, Weiran Chai, Yanping Kuang   +14 more
doaj   +1 more source