Results 41 to 50 of about 10,362 (160)

A concept for a new approach to combined oral contraception from adolescence to perimenopause: Continuous use of the oral GnRH antagonist Relugolix and the fetal estrogen Estetrol

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
It is expected that the relugolix estetrol combination RE4W will enable women to control their fertility and prevent menstrual cycle related problems, while offering a smooth transition through perimenopause into the postmenopause and decrease the risk of breast cancer.
Herjan J. T. Coelingh Bennink, Karolina Afors, Luis Bahamondes, Alessandra Graziottin, Deborah Bateson, Teresa Bombas, Yutaki Osuga, Santiago Palacios, Carolyn L. Westhoff, Kristina Gemzell‐Danielsson   +9 more
wiley   +1 more source

Update on Menopause Hormone Therapy; Current Indications and Unanswered Questions

Clinical Endocrinology, EarlyView.
ABSTRACT Objective To provide clinicians involved in managing menopause with a summary of current evidence surrounding menopause hormone therapy (MHT). Design The authors evaluate and synthesize existing pooled evidence relating to MHT's clinical indications, efficacy, and safety and explore the limitations of existing data. Patients The review focuses
Annice Mukherjee, Susan R. Davis
wiley   +1 more source

Characterization of a novel telomerase-immortalized human endometrial stromal cell line, St-T1b

Reproductive Biology and Endocrinology, 2009
Background Coordinated differentiation of the endometrial compartments in the second half of the menstrual cycle is a prerequisite for the establishment of pregnancy. Endometrial stromal cells (ESC) decidualize under the influence of ovarian progesterone
Brosens Jan J, Schulte Heinrich M, Wittmann Stefanie, Reimann Katja, Samalecos Annemarie, Bamberger Ana-Maria, Gellersen Birgit   +6 more
doaj   +1 more source

Vascular health and exercise in females throughout the lifespan: Exploring puberty, pregnancy and menopause

Experimental Physiology, EarlyView.
Abstract This narrative review highlights the impact of exercise on vascular health in females over the lifespan with an emphasis on puberty, pregnancy and menopause. These events encompass substantial changes in sex hormone levels, particularly oestrogens and progesterone.
Kathleen B. Miller, M. Erin Moir, Brandon G. Fico   +2 more
wiley   +1 more source

Non‐Invasive Assessment of Complete Regression in Endometrial Cancer Patients Undergoing Fertility Preservation Using MRI‐Based Radiomics and Immune Heterogeneity

MedComm, Volume 7, Issue 3, March 2026.
Fertility preservation therapy allows young women with early EC to preserve fertility. We developed a non‐invasive MRI radiomics model to predict treatment success. It accurately identifies patients less likely to achieve remission, linking this to an immunosuppressive tumor environment. This aids personalized treatment planning.
Xingchen Li, Kun Shang, Jingyuan Wang, Aoxuan Zhu, Yuman Wu, Yue Qi, Xinyi Bi, Yiqin Wang, Jianliu Wang   +8 more
wiley   +1 more source

Considerations for Menstrual Suppression in Patients With Hematologic Malignancies

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 3, March 2026.
ABSTRACT Patients who menstruate during treatment for hematologic malignancies have a higher risk of heavy vaginal bleeding due to thrombocytopenia caused by malignancy and myelosuppressive chemotherapy. Heavy menstrual bleeding is associated with significant morbidity in this patient population, and menstrual suppression is a standard of supportive ...
Sahaana Veeravalli, Allison Schepers, Lydia L. Benitez, Martina S. Fraga   +3 more
wiley   +1 more source

Development of a subcutaneous endometriosis rat model [PDF]

Acta Cirúrgica Brasileira, 2015
PURPOSE:To present a rat model of subcutaneous endometriosis for the study of pathophysiology and the effects of drugs.METHODS: Fifty three-month-old female Wistar rats (Rattus norvergicus) were distributed into one control group and four treatment ...
Francisco Edson Ximenes Gomes Pereira, Paulo Roberto Carvalho de Almeida, Bruno Hállan Meneses Dias, Paulo Roberto Leitão de Vasconcelos, Sérgio Botelho Guimarães, Francisco das Chagas Medeiros   +5 more
doaj   +1 more source

Menstrual suppression to decrease intrauterine device expulsion in adolescents with inherited bleeding disorders

International Journal of Gynecology &Obstetrics, Volume 169, Issue 1, Page 421-423, April 2025.
Peter H. Cygan, Kelly M. Kons, Megan H. Fiorillo, Tonya S. Wright   +3 more
wiley   +1 more source

Using PBPK to Simulate Target Biopredictive Dissolution Profiles for Long‐Acting Injectables ‐ Where to Begin With Critical Bioavailability Attributes?

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 3, March 2026.
ABSTRACT Long‐acting injectables (LAI) are of increasing interest as they facilitate improved medication adherence and exposure, with target plasma concentration levels maintained over weeks/months. Biopredictive in vitro dissolution tests can aid formulation development of LAIs and guide quality control dissolution testing by facilitating accelerated ...
Hannah Cleary, Nikoletta Fotaki, Tim Persoons, Deirdre M. D'Arcy   +3 more
wiley   +1 more source

Sonar findings of the uterus in patients on medroxyprogesterone acetate (Depo Provera) 150 mg injection

South African Family Practice, 2009
Background: Depo Provera (medroxyprogesterone acetate) 150 mg intramuscular injection every 12 weeks is one of the most common, effective, affordable and popular methods of contraception.
Louis A. de Wilde, Wilhelm J. Steinberg, Mariette Nel   +2 more
doaj   +1 more source