Results 81 to 90 of about 1,166 (192)

Highly Regioselective 1,3-Dipolar Cycloaddition of Nitrilimines and Thioaurones Towards Spiro-2-Pyrazolines: Synthesis, Characterization, and Mechanistic Study

Reactions
In this paper, we report a highly regioselective 1,3-dipolar cycloaddition (1,3-DC) reaction of nitrilimines with thioaurone derivatives that afforded the hitherto unreported spiropyrazolines. Spectroscopic and spectrometric data were utilized to confirm
Mohamed Bakhouch, Bouchra Es-Sounni, Ayoub Ouaddi, Khaoula Oudghiri, Mohammed Chalkha, Lahoucine Bahsis, Taoufiq Benali, Mohamed Bourass, Rabiaa Fdil, Mohamed Akhazzane, Mohamed El Yazidi   +10 more
doaj   +1 more source

The Puzzle of the New Type of Intermediate in the Course of [2 + 2] Cycloaddition with the Participation of Conjugated Nitroalkenes: MEDT Computational Study

Molecules
The phenomena of regio- and stereoselectivity and the molecular mechanism of the [2 + 2] cycloaddition reaction between (E)-2-arylnitroethenes and the ynamine molecular system were analyzed using wb97xd/6-311 + G(d) (PCM) quantumchemical calculations.
Radomir Jasiński, Agnieszka Kącka-Zych
openaire   +4 more sources

MEDT 423 Clinical Laboratory Science: Microbiology III

, 1985
Course syllabus for MEDT 423 Clinical Laboratory Science: Microbiology III Course description: This lecture series covers parasitology and serology with emphasis on the correlation of the human immune response with laboratory ...
Molander, Leonard, Coleman, Clementine
core  

The Contribution of Moisture Sources of Precipitation to Water Resources Recharge in Semi-Arid Regions

Atmosphere
This study investigates the isotopic composition of precipitation in Iran and its moisture sources, offering insights crucial for addressing water recharge and management in semi-arid regions.
Hossein Mohammadzadeh, Rogert Sorí, Mojtaba Heydarizad   +2 more
doaj   +1 more source

A Molecular Electron Density Theory Study of the Chemoselectivity, Regioselectivity, and Diastereofacial Selectivity in the Synthesis of an Anticancer Spiroisoxazoline derived from α-Santonin

Molecules, 2019
The [3 + 2] cycloaddition (32CA) reaction of an α-santonin derivative, which has an exocyclic C⁻C double bond, with p-bromophenyl nitrile oxide yielding only one spiroisoxazoline, has been studied within the molecular electron density theory ...
Luis R. Domingo, Mar Ríos-Gutiérrez, Nivedita Acharjee   +2 more
doaj   +1 more source

Insights into the mechanism, selectivity, and substituent effects in the Diels-Alder reaction of azatrienes with electron-rich dienophiles: An MEDT study

Journal of Molecular Graphics and Modelling
accepted in Journal of Molecular Graphics and ...
Rafik, Amine, Jaddi, Abdeljabbar, Salah, Mohammed, Komiha, Najia, Carvajal, Miguel, Marakchi, Khadija   +5 more
openaire   +3 more sources

A Molecular Electron Density Theory Study of the Synthesis of Spirobipyrazolines through the Domino Reaction of Nitrilimines with Allenoates

Molecules, 2019
The reaction of diphenyl nitrilimine (NI) with methyl 1-methyl-allenoate yielding a spirobipyrazoline has been studied within molecular electron density theory (MEDT) at the MPWB1K/6-311G(d) computational level in dichloromethane.
Luis R. Domingo, Fatemeh Ghodsi, Mar Ríos-Gutiérrez   +2 more
doaj   +1 more source

MEDT 333 Clinical Laboratory Science: Microbiology II

, 1985
Course syllabus for MEDT 333 Clinical Laboratory Science: Microbiology II Course description: This course is the second in a series of four Clinical Microbiology courses. The area of emphasis are gram negative bacilli, acid fast bacilli, antibiotics, and
Shen, Min, Coleman, Clementine
core   +1 more source

Indenoquinoxaline-Based Spiro-Heterocycles: Synthesis, Structural Characterization, MEDT Study, and Dual Inhibition of Kinase-Related Enzymes EGFR and VEGFR2. [PDF]

Chem Biodivers
ABSTRACT A new series of spiro‐heterocycles derived from pyrazole–indenoquinoxaline scaffolds 4a–n and 5a–m was designed and synthesized via one‐pot multi‐component reaction‐based a [3 + 2] cycloaddition reaction (32CA).
Alayyaf AA, Alamary AS, Islam MS, Ali M, Barakat A, Bari A, Domingo LR, Darwish KM, Khamis MA, Emara M, Elshamy AM, Mirgany TO, Nafie MS.   +12 more
europepmc   +3 more sources

Activation of p53 signaling and regression of breast and prostate carcinoma cells by spirooxindole-benzimidazole small molecules

Frontiers in Pharmacology
This study discusses the synthesis and use of a new library of spirooxindole-benzimidazole compounds as inhibitors of the signal transducer and activator of p53, a protein involved in regulating cell growth and cancer prevention.
Assem Barakat, Saeed Alshahrani, Abdullah Mohammed Al-Majid, Abdullah Saleh Alamary, Matti Haukka, Marwa M. Abu-Serie, Alexander Dömling, Luis R. Domingo, Yaseen A. M. M. Elshaier   +8 more
doaj   +1 more source