Results 51 to 60 of about 273,677 (294)

Risk Factors for Lateral Lymph Node Metastases in Patients With Sporadic Medullary Thyroid Carcinoma

Technology in Cancer Research & Treatment, 2020
Purpose: Medullary thyroid carcinoma is a rare endocrine malignancy; 75% of patients with this disease have sporadic medullary thyroid carcinoma. While surgery is the only curative treatment, the benefit of prophylactic lateral neck dissection is unclear.
Xin Wu MD, Binglu Li MD, Chaoji Zheng MD, Wei Liu MD, Tao Hong MD, Xiaodong He MD   +5 more
doaj   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

GABAergic parafacial zone is a medullary slow–wave–sleep promoting center

Nature Neuroscience, 2014
Work in animals and humans has suggested the existence of a slow wave sleep (SWS)-promoting/electroencephalogram (EEG)-synchronizing center in the mammalian lower brainstem.
C. Anaclet, L. Ferrari, E. Arrigoni, C. Bass, C. Saper, Jun Lu, P. Fuller   +6 more
semanticscholar   +1 more source

Understanding the Effects of Conductive Polymer Electrode Coating on Recorded Neural Signals

Advanced Healthcare Materials, EarlyView.
Conductive polymer coatings are widely explored to improve the quality of signals recorded with chronically implanted neural electrodes, offering enhanced biocompatibility along with reduced electrode impedance. Combining computational modelling and data from PEDOT:PTS coated and PtIr electrodes in rats, we show that improvements in signal quality with
Karthik Sridhar, Judith Evers, Alexandre Trotier, Manus Biggs, Madeleine M. Lowery   +4 more
wiley   +1 more source

Medullary bone in an Early Cretaceous enantiornithine bird and discussion regarding its identification in fossils

Nature Communications, 2018
Medullary bone is used by modern female birds as a calcium reservoir for eggshell production. Here, O’Connor and colleagues propose criteria for identifying medullary bone in fossils and report medullary bone from a Cretaceous enantiornithine bird fossil.
Jingmai O’Connor, Gregory M. Erickson, Mark Norell, Alida M. Bailleul, Han Hu, Zhonghe Zhou   +5 more
doaj   +1 more source

Three‐Dimensional Ovary Model to Improve and Study Murine Follicle Growth

Advanced Healthcare Materials, EarlyView.
To develop new methods for fertility preservation in women, novel culture systems for small follicles need to be established. In this work, a poly(ethylene glycol) based scaffold, with appropriate mechanical and bioactive features to support mouse follicle and ovary cell growth is developed, and the formed cell‐follicle interactions are visualized ...
Mira Jacobs, Valon Gllareva, Lukas Moser, Silvia Pravato, Eric Mora Pimentel, Brigitte Leeners, Martin Ehrbar   +6 more
wiley   +1 more source

CCR4 promotes medullary entry and thymocyte–dendritic cell interactions required for central tolerance

Journal of Experimental Medicine, 2015
Hu et al. show that the chemokine receptor CCR4 is involved in thymocyte medullary entry, interactions with dendritic cells, and negative selection. In the absence of CCR4, central tolerance is not established, promoting autoimmunity.
Zicheng Hu, Jessica N. Lancaster, Chayanit Sasiponganan, Lauren I. R. Ehrlich   +3 more
semanticscholar   +1 more source

Educational Case: Endocrine Neoplasm

Academic Pathology, 2018
Medullary thyroid cancer is a rare neuroendocrine tumor that arises the neural crest-derived parafollicular C cells and accounts for approximately 5% to 10% of thyroid cancers worldwide.
Sheila Segura MD, Gloria Ramos-Rivera MD, Mark Suhrland MD   +2 more
doaj   +1 more source

The Three-Dimensional Morphology of Femoral Medullary Cavity in the Developmental Dysplasia of the Hip

Frontiers in Bioengineering and Biotechnology, 2021
ObjectiveThis study aimed to assess the morphology of the femoral medullary canal in subjects with developmental dysplasia of the hip (DDH) with the intent of improving the design of femoral stems in total hip arthroplasty.MethodsComputed tomography ...
Min Zhang, Bo-Lun Liu, Xin-Zheng Qi, Qing-Qing Yang, Jing-Yang Sun, Qing-Yuan Zheng, Guo-Qiang Zhang, Cheng-Kung Cheng, Cheng-Kung Cheng   +8 more
doaj   +1 more source

Bone Healing Around Implants in Normal and Medically Compromised Conditions: Osteoporosis and Diabetes

Advanced Healthcare Materials, EarlyView.
xx xx. ABSTRACT Osseointegration of orthopedic and dental implants is influenced by local and systemic factors, including their physicochemical surface properties and the patient's overall health status. Titanium and its alloys have been a longstanding standard for bone implants due to their innate biocompatibility and mechanical properties.
Dainelys Guadarrama Bello, Fabio Variola, Antonio Nanci   +2 more
wiley   +1 more source