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Real-World Efficacy and Safety of Cabozantinib and Vandetanib in Advanced Medullary Thyroid Cancer
Thyroid, 2020Background: Management of patients with advanced medullary thyroid cancer (MTC) remains a therapeutic challenge. The multi-tyrosine kinase inhibitors (TKIs) vandetanib and cabozantinib have been approved for the treatment of progressive MTC based on ...
V. Koehler +9 more
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2021
In this chapter while following the clinical course of a patient diagnosed with medullary thyroid cancer (MTC), the reader will be acquainted with the basic clinical features, diagnosis, and treatment of this rare tumor.
Victor A. Gall, Amanda M. Laird
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In this chapter while following the clinical course of a patient diagnosed with medullary thyroid cancer (MTC), the reader will be acquainted with the basic clinical features, diagnosis, and treatment of this rare tumor.
Victor A. Gall, Amanda M. Laird
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Endocrine Abstracts, 2015
Medullary thyroid cancer (MTC) is an uncommon disease, accounting for 3–10 % of all thyroid cancers worldwide [1–3]. The German literature contains reports of a thyroid malignancy with amyloid deposits as early as 1906, but it was not until 1959 when Hazard and co-workers reported on a clinicopathological, solid arrangement of cells, which represented ...
Laura Chin-Lenn, Janice L. Pasieka
+4 more sources
Medullary thyroid cancer (MTC) is an uncommon disease, accounting for 3–10 % of all thyroid cancers worldwide [1–3]. The German literature contains reports of a thyroid malignancy with amyloid deposits as early as 1906, but it was not until 1959 when Hazard and co-workers reported on a clinicopathological, solid arrangement of cells, which represented ...
Laura Chin-Lenn, Janice L. Pasieka
+4 more sources
Sporadic Medullary Thyroid Cancer
2009Medullary thyroid cancer (MTC), is a tumor of the parafollicular / c-cells of the thyroid gland. These cells are derived from the embryonic neural crests and make up 1% of the thyroid cells. C-cells can be found anywhere in the gland but are concentrated in the upper poles of the thyroid lobes.
Adrian, Harvey, Janice L, Pasieka
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Thyroid, 2020
Background: Thyroid cancer is the most common endocrine tumor with an increasing incidence. Limited treatment options are available for patients with advanced or recurrent metastatic disease, resulting in a poor prognosis.
Jia-ying Chen +14 more
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Background: Thyroid cancer is the most common endocrine tumor with an increasing incidence. Limited treatment options are available for patients with advanced or recurrent metastatic disease, resulting in a poor prognosis.
Jia-ying Chen +14 more
semanticscholar +1 more source
Nature Communications
Neurotransmitters are key modulators in neuro-immune circuits and have been linked to tumor progression. Medullary thyroid cancer (MTC), an aggressive neuroendocrine tumor, expresses neurotransmitter calcitonin gene-related peptide (CGRP), is insensitive
Yingtong Hou +18 more
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Neurotransmitters are key modulators in neuro-immune circuits and have been linked to tumor progression. Medullary thyroid cancer (MTC), an aggressive neuroendocrine tumor, expresses neurotransmitter calcitonin gene-related peptide (CGRP), is insensitive
Yingtong Hou +18 more
semanticscholar +1 more source
Surgical Clinics of North America, 1995
Medullary thyroid cancer is a tumor of the thyroid C cells that occurs in sporadic and hereditary clinical settings. Genetic testing of at-risk individuals is available and has been applied to patient management. Plasma calcitonin levels are a very sensitive marker for the presence of disease.
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Medullary thyroid cancer is a tumor of the thyroid C cells that occurs in sporadic and hereditary clinical settings. Genetic testing of at-risk individuals is available and has been applied to patient management. Plasma calcitonin levels are a very sensitive marker for the presence of disease.
openaire +2 more sources
British Journal of Surgery, 2020
BACKGROUND Medullary thyroid cancer can be subdivided during surgery into tumours with or without a desmoplastic stromal reaction (DSR). DSR positivity is regarded as a sign of disposition to metastasize.
M. Niederle +6 more
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BACKGROUND Medullary thyroid cancer can be subdivided during surgery into tumours with or without a desmoplastic stromal reaction (DSR). DSR positivity is regarded as a sign of disposition to metastasize.
M. Niederle +6 more
semanticscholar +1 more source
International Journal of Molecular Sciences
Thyroid cancer (TC) invariably remains the most prevalent endocrine cancer in the world. Major histological forms of TC include papillary (PTC), follicular (FTC), medullary (MTC), and anaplastic thyroid carcinoma (ATC), each of which has a unique ...
Alicja Forma +6 more
semanticscholar +1 more source
Thyroid cancer (TC) invariably remains the most prevalent endocrine cancer in the world. Major histological forms of TC include papillary (PTC), follicular (FTC), medullary (MTC), and anaplastic thyroid carcinoma (ATC), each of which has a unique ...
Alicja Forma +6 more
semanticscholar +1 more source
Anlotinib for the Treatment of Patients with Locally Advanced or Metastatic Medullary Thyroid Cancer
Thyroid, 2018Background: The prognosis of advanced or metastatic medullary thyroid carcinoma (MTC) is poor, and there are few therapeutic options. Anlotinib has previously shown promising antitumor activity on MTC in preclinical models and a Phase I study. This Phase
Yongkun Sun +11 more
semanticscholar +1 more source