Therapeutic targeting of chromatin alterations in leukemia and solid tumors
International Journal of Cancer, Volume 158, Issue 2, Page 382-408, 15 January 2026.Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner +7 more
wiley +1 more source
Pediatric glioma and medulloblastoma risk and population demographics: a Poisson regression analysis [PDF]
, 2020 Ivo S. Muskens +7 more
openalex +1 more source
Deregulated enhancer‐promoter communication in cancer through altered nuclear architecture
International Journal of Cancer, Volume 158, Issue 2, Page 409-422, 15 January 2026.Abstract Enhancers are critical regulators of gene expression. Structural variations in cancer genomes can lead to enhancer hijacking, where oncogenes are activated by mistargeted enhancer activity. Novel enhancer‐promoter interactions may also arise through chromosomal rearrangements that create extrachromosomal DNA elements.
Isabelle Seufert +3 more
wiley +1 more source
Supplementary Figure 4 from MyoD Is a Tumor Suppressor Gene in Medulloblastoma [PDF]
, 2023 Joyoti Dey +11 more
openalex +1 more source
HOXB4 Promotes Bladder Cancer Progression in Part Through Transcriptional Activation of Smoothened
The FASEB Journal, Volume 40, Issue 1, 15 January 2026.HOXB4 is overexpressed in bladder cancer and associated with poor prognosis. By transcriptionally activating Smoothened (SMO), HOXB4 amplifies SMO–GLI signaling to promote tumor growth and metastatic behavior. This graphical abstract highlights the HOXB4–SMO axis as a key driver of bladder cancer progression and a potential target for future ...
Zhaoheng Jin +6 more
wiley +1 more source
Supplementary Table 1 from REST Is a Novel Prognostic Factor and Therapeutic Target for Medulloblastoma [PDF]
, 2023 Peter Taylor +10 more
openalex +1 more source
Dual and opposing roles of primary cilia in medulloblastoma development. [PDF]
, 2009 Recent work has shown that primary cilia are essential for Hedgehog (Hh) signaling during mammalian development. It is also known that aberrant Hh signaling can lead to cancer, but the role of primary cilia in oncogenesis is not known. Cerebellar granule
Alvarez-Buylla, Arturo +5 more
core
Harnessing Next‐Generation 3D Cancer Models to Elucidate Tumor‐Microbiome Crosstalk
Advanced Healthcare Materials, Volume 15, Issue 1, 9 January 2026.Centralizes the microbiome within 3D tumor‐microbiome model platforms, including spheroids, organoids, 3D‐bioprinted constructs, and microfluidic chips, each enabling structured host‐tumor‐microbe studies. These systems support bacterial colonization, facilitating investigation of microbial impacts on tumor growth, immunity, and therapy. The microbiome
Marina Green Buzhor +12 more
wiley +1 more source
Identification of tumor rejection antigens and the immunologic landscape of medulloblastoma
Genome MedicineBackground The current standard of care treatments for medulloblastoma are insufficient as these do not take tumor heterogeneity into account. Newer, safer, patient-specific treatment approaches are required to treat high-risk medulloblastoma patients ...
Changlin Yang +6 more
doaj +1 more source
Nanobiotechnology‐Based Approaches for Targeted Glioma Therapy
Advanced NanoBiomed Research, Volume 6, Issue 1, January 2026.Nanoparticle systems cross the blood–brain barrier to deliver drugs precisely to glioma cells. Lipid, polymeric, and magnetic carriers enable controlled release, tumor targeting, and microenvironment modulation. These nanoplatforms enhance chemotherapy, radiotherapy, and immunotherapy, improving therapeutic efficacy while reducing systemic toxicity ...
Jinwei Li +11 more
wiley +1 more source