Results 121 to 130 of about 150,521,404 (284)
Chronological and replicative lifespan in yeast: do they meet in the middle? [PDF]
Cell Cycle, 2012 Polymenis M, Kennedy BK.
europepmc +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Middle Powers in Asia and Europe in the 21st Century Foreign policies of the middle powers.
, 2020 Description based upon print version of record.Small State or Middle Power?This volume argues that middle powers are important to 21st Century world politics in performing roles as (aspiring) global middle powers, regional pivots, and niche leaders. This
de Pantz Federica. +8 more
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On the Complexity of Implementation Some Cryptanalysis Methods by Distributed Computing
Безопасность информационных технологий, 2011 The subject of the research is an investigation on the distributed computing efficiency in the analysis of cryptographic systems by different key search methods: meet-in-the-middle, sequential key search and Hellman method.
A. A. Varfolomeev +3 more
doaj
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Cremation in the Early Middle Ages: Death, fire and identity in North-West Europe [PDF]
Introducing this first-ever edited collection drawing together the latest research on the cremation of the dead in early medieval North-West Europe, the chapter identifies, rationalises and contextualises the book’s aims: to rethink the burning of the ...
Lippok, Femke, Williams, Howard
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FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
A vulnerability approach to the definition of the middle class [PDF]
Measurement of the middle class has recently come to the center of policy debate in middle-income countries as they search for the potential engines of growth and good governance. This debate assumes, first, that there is a meaningful definition of class,
Ortiz-Juarez, Eduardo +1 more
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