Results 21 to 30 of about 2,622,186 (362)

Lipid droplets modulate proteostasis, SQST-1/SQSTM1 dynamics, and lifespan in C. elegans

iScience, 2023
Summary: In several long-lived Caenorhabditis elegans strains, such as insulin/IGF-1 receptor daf-2 mutants, enhanced proteostatic mechanisms are accompanied by elevated intestinal lipid stores, but their role in longevity is unclear.
Anita V. Kumar, Joslyn Mills, Wesley M. Parker, Joshua A. Leitão, Diego I. Rodriguez, Sandrine E. Daigle, Celeste Ng, Rishi Patel, Joseph L. Aguilera, Joseph R. Johnson, Shi Quan Wong, Louis R. Lapierre   +11 more
doaj   +1 more source

The Banff 2019 Kidney Meeting Report (I): Updates on and clarification of criteria for T cell– and antibody‐mediated rejection

American Journal of Transplantation, 2020
The XV. Banff conference for allograft pathology was held in conjunction with the annual meeting of the American Society for Histocompatibility and Immunogenetics in Pittsburgh, PA (USA) and focused on refining recent updates to the classification ...
A. Loupy, M. Haas, C. Roufosse, M. Naesens, B. Adam, M. Afrouzian, E. Akalin, N. Alachkar, S. Bagnasco, J. Becker, L. Cornell, M. C. Clahsen‐van Groningen, A. Demetris, D. Dragun, J. Duong van Huyen, A. Farris, A. Fogo, I. Gibson, D. Glotz, Juliette Gueguen, Ž. Kikić, N. Kozakowski, E. Kraus, C. Lefaucheur, H. Liapis, R. Mannon, R. Montgomery, B. Nankivell, V. Nickeleit, P. Nickerson, M. Rabant, L. Racusen, P. Randhawa, B. Robin, I. Rosales, R. Sapir-Pichhadze, C. Schinstock, D. Serón, H. Singh, R. Smith, M. Stegall, A. Zeevi, K. Solez, R. Colvin, M. Mengel   +44 more
semanticscholar   +1 more source

A synDNA vaccine delivering neoAg collections controls heterogenous, multifocal murine lung and ovarian tumors via robust T cell generation

Molecular Therapy: Oncolytics, 2021
Neoantigens are tumor-specific antigens that arise due to somatic mutations in the DNA of tumor cells. They represent ideal targets for cancer immunotherapy since there is minimal risk for on-target, off-tumor toxicities.
Pratik S. Bhojnagarwala, Alfredo Perales-Puchalt, Neil Cooch, Niranjan Y. Sardesai, David B. Weiner   +4 more
doaj   +1 more source

The Incidence, Prevalence, and Associated Costs of Anemia, Malignancy, Venous Thromboembolism, Major Adverse Cardiovascular Events, and Infections in Rheumatoid Arthritis Patients by Treatment History in the United States

ACR Open Rheumatology, 2022
Objective Comorbidities in rheumatoid arthritis (RA) can influence treatment selection, impact treatment persistency, and increase health care costs. This study assessed the magnitude of comorbidity burden via epidemiology (incidence and prevalence) and ...
Robin K. Dore, Jenya N. Antonova, Chakkarin Burudpakdee, Lawrence Chang, Magdaliz Gorritz, Mark C. Genovese   +5 more
doaj   +1 more source

Intradermal-delivered DNA vaccine induces durable immunity mediating a reduction in viral load in a rhesus macaque SARS-CoV-2 challenge model

Cell Reports Medicine, 2021
Summary: Coronavirus disease 2019 (COVID-19), caused by the SARS-CoV-2 virus, has had a dramatic global impact on public health and social and economic infrastructures.
Ami Patel, Jewell N. Walters, Emma L. Reuschel, Katherine Schultheis, Elizabeth Parzych, Ebony N. Gary, Igor Maricic, Mansi Purwar, Zeena Eblimit, Susanne N. Walker, Diana Guimet, Pratik Bhojnagarwala, Opeyemi S. Adeniji, Arthur Doan, Ziyang Xu, Dustin Elwood, Sophia M. Reeder, Laurent Pessaint, Kevin Y. Kim, Anthony Cook, Neethu Chokkalingam, Brad Finneyfrock, Edgar Tello-Ruiz, Alan Dodson, Jihae Choi, Alison Generotti, John Harrison, Nicholas J. Tursi, Viviane M. Andrade, Yaya Dia, Faraz I. Zaidi, Hanne Andersen, Mohamed Abdel-Mohsen, Mark G. Lewis, Kar Muthumani, J. Joseph Kim, Daniel W. Kulp, Laurent M. Humeau, Stephanie J. Ramos, Trevor R.F. Smith, David B. Weiner, Kate E. Broderick   +41 more
doaj   +1 more source

Immunogenicity of a DNA vaccine candidate for COVID-19

Nature Communications, 2020
There is currently no licensed SARS-CoV-2 vaccine. Here, the authors generate an optimized DNA vaccine candidate encoding the SARS-CoV-2 spike antigen, demonstrating induction of specific T cells and neutralizing antibody responses in mice and guinea ...
Trevor R. F. Smith, Ami Patel, Stephanie Ramos, Dustin Elwood, Xizhou Zhu, Jian Yan, Ebony N. Gary, Susanne N. Walker, Katherine Schultheis, Mansi Purwar, Ziyang Xu, Jewell Walters, Pratik Bhojnagarwala, Maria Yang, Neethu Chokkalingam, Patrick Pezzoli, Elizabeth Parzych, Emma L. Reuschel, Arthur Doan, Nicholas Tursi, Miguel Vasquez, Jihae Choi, Edgar Tello-Ruiz, Igor Maricic, Mamadou A. Bah, Yuanhan Wu, Dinah Amante, Daniel H. Park, Yaya Dia, Ali Raza Ali, Faraz I. Zaidi, Alison Generotti, Kevin Y. Kim, Timothy A. Herring, Sophia Reeder, Viviane M. Andrade, Karen Buttigieg, Gan Zhao, Jiun-Ming Wu, Dan Li, Linlin Bao, Jiangning Liu, Wei Deng, Chuan Qin, Ami Shah Brown, Makan Khoshnejad, Nianshuang Wang, Jacqueline Chu, Daniel Wrapp, Jason S. McLellan, Kar Muthumani, Bin Wang, Miles W. Carroll, J. Joseph Kim, Jean Boyer, Daniel W. Kulp, Laurent M. P. F. Humeau, David B. Weiner, Kate E. Broderick   +58 more
doaj   +1 more source

cIMPACT‐NOW update 6: new entity and diagnostic principle recommendations of the cIMPACT‐Utrecht meeting on future CNS tumor classification and grading

Brain Pathology, 2020
cIMPACT‐NOW (the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy) was established to evaluate and make practical recommendations on recent advances in the field of CNS tumor classification, particularly in light of the rapid
D. Louis, P. Wesseling, K. Aldape, D. Brat, D. Capper, I. Cree, C. Eberhart, D. Figarella-Branger, M. Fouladi, G. Fuller, C. Giannini, C. Haberler, C. Hawkins, T. Komori, J. Kros, HK Ng, B. Orr, Sung-Hye Park, W. Paulus, A. Perry, T. Pietsch, G. Reifenberger, M. Rosenblum, B. Rous, F. Sahm, C. Sarkar, D. Solomon, U. Tabori, M. J. Bent, A. Deimling, M. Weller, V. White, D. Ellison   +32 more
semanticscholar   +1 more source

Neurodegenerative disorders: Insights from the nematode Caenorhabditis elegans

Neurobiology of Disease, 2010
Neurodegenerative diseases impose a burden on society, yet for the most part, the mechanisms underlying neuronal dysfunction and death in these disorders remain unclear despite the identification of relevant disease genes.
Maria Dimitriadi, Anne C. Hart
doaj   +1 more source

Adherence and Persistence Patterns in Medication Use Among Men With Lower Urinary Tract Symptoms/Benign Prostatic Hyperplasia

American Journal of Men's Health, 2017
Medication adherence and persistence patterns among patients with lower urinary tract symptoms/benign prostatic hyperplasia (LUTS/BPH) were analyzed.
Emily Shortridge PhD, Craig Donatucci MD, Prina Donga MS, Michael Marcus MS, Rolin L. Wade MS, RPh   +4 more
doaj   +1 more source

Exploring the influence of scheduled meetings on physiological indicators of hospitalized patients satisfaction facing acute myocardial infarction in the intensive care unit

Journal of Education and Health Promotion, 2022
BACKGROUND: Satisfaction of patients is among the top priorities of health-care providers. Meeting with families is essential for patients who are admitted to various wards, although it has been restricted for many reasons such as its impact on ...
Marzieh Najafi, Hakimeh Mohammadzadeh, Nasrin Heydarian, Mohammad Rostami, Tooba Ebadi Fard Azar, Fatemeh Mahmoodi, Fakhreddin Chaboksavar, Gholamreza Garmaroudi   +7 more
doaj   +1 more source