Results 51 to 60 of about 14,419 (158)

Male-Biased Aganglionic Megacolon in the TashT Mouse Line Due to Perturbation of Silencer Elements in a Large Gene Desert of Chromosome 10

PLoS Genetics, 2015
Neural crest cells (NCC) are a transient migratory cell population that generates diverse cell types such as neurons and glia of the enteric nervous system (ENS).
K. Bergeron, Tatiana Cardinal, A. M. Touré, M. Béland, D. Raiwet, D. Silversides, N. Pilon   +6 more
semanticscholar   +1 more source

Exploratory Clinical Study to Evaluate the Efficacy and Safety of Sulfasalazine for Immune Checkpoint Inhibitor (ICI)‐Induced Colitis

JGH Open, Volume 10, Issue 2, February 2026.
ABSTRACT Background The first‐choice treatment for immune checkpoint inhibitor (ICI)‐induced colitis is steroids; however, side effects may occur and survival may be reduced. Sulfasalazine (SSZ) is primarily used for inflammatory bowel disease but studies on ICI‐induced colitis are scarce.
Mariko Kobayashi, Takeshi Yamada, Shunsuke Ueyama, Yoshiyuki Yamamoto, Akinori Sugaya, Yoshinori Hiroshima, Takashi Mamiya, Junji Hattori, Shintaro Akiyama, Bryan J. Mathis, Kiichiro Tsuchiya   +10 more
wiley   +1 more source

Profile of interstitial cells of Cajal in a murine model of chagasic megacolon [PDF]

Anais da Academia Brasileira de Ciências
Disorders of gastrointestinal motility are the major physiologic problem in chagasic megacolon. The contraction mechanism is complex and controlled by different cell types such as enteric neurons, smooth muscle, telocytes, and an important pacemaker of ...
MAYRA FERNANDA RICCI, ANA L. MAZZETI, JOANA L. BARBOSA, FABIANA S. MACHADO, MARIA TEREZINHA BAHIA, ROSA MARIA E. ARANTES, SAMANTHA R. SOUZA   +6 more
doaj   +1 more source

Severe hyponatremia and repeated intestinal resections for intestinal dysmotility mimicking congenital aganglionic megacolon due to delay in the diagnosis of congenital hypothyroidism

Annals of Pediatric Endocrinology & Metabolism, 2016
Congenital hypothyroidism (CH) may present with nonspecific signs and symptoms, though, majority of infants can be asymptomatic. Therefore, understimation and delay in diagnosis may result in severe complications.
G. Buyukyilmaz, Demet Baltu, T. Soyer, M. Tanyildiz, H. Demirbilek   +4 more
semanticscholar   +1 more source

Campylobacter colitis: Rare cause of toxic megacolon

International journal of surgery case reports, 2016
Highlights • Campylobacter colitis is usually self-limited but life-threatening toxic megacolon can occur.• Toxic megacolon is characterised by non-obstructive colonic dilatation, combined with evidence of systemic toxicity.• Early surgical consultation ...
Michael Kwok, A. Maurice, Carl Lisec, Jason Brown   +3 more
semanticscholar   +1 more source

Preliminary non‐comparative evaluation of an adapted colonoscopy preparation protocol for dogs using sodium picosulphate and magnesium citrate

Veterinary Record, Volume 198, Issue 3, Page e101-e107, 31 January/7 February 2026.
Abstract Background Challenges associated with bowel cleansing protocols for canine colonoscopy include practical applicability and inadequate preparations. This study aimed to describe and evaluate an adapted protocol to simplify colonoscopy preparation in dogs.
Julia Elia da Silva Paranhos, Melissa Guillen Gonçalves de Souza, Daniela Araujo de Sousa, Debora Costabile Soibelman, Sabrina Martins da Costa Ferreira, Juliana da Silva Leite, Bruno Penna, Ana Maria Reis Ferreira   +7 more
wiley   +1 more source

Association of chagasic megacolon and cancer of the colon: case report and review of the literature

Revista da Sociedade Brasileira de Medicina Tropical, 2002
There are few descriptions of association between chagasic megacolon and colon cancer. We report a case of obstructive abdomen caused by adenocarcinoma of the left colon in chagasic megacolon.
Sheila Jorge Adad, Renata Margarida Etchebehere, José Ribamar de Araújo, Andrea Berdu Madureira, Vanessa Guimarães Freitas Lima, Alex Augusto da Silva, Crema Eduardo   +6 more
doaj  

Fatal Toxic Megacolon in a Child of Hirschsprung Disease.

Journal of clinical and diagnostic research : JCDR, 2016
Hirschsprung disease (HD) in late childhood is uncommon and often undiagnosed or misdiagnosed. However, in a patient with Hirschsprung disease, of greater significance is the occurrence of life threatening enterocolitis.
Shiwani Garg, P. Sathe, A. Taware, K. M. Surve   +3 more
semanticscholar   +1 more source

Inflammatory bowel disease and metabolic reprogramming: From pathological mechanisms to targeted interventions

Interdisciplinary Medicine, Volume 4, Issue 1, January 2026.
This review explores the role of metabolic reprogramming in inflammatory bowel disease (IBD) by focusing on immune and epithelial cell metabolism, microbial metabolites, and their impact on inflammation. It discusses emerging metabolic therapies and emphasizes the importance of personalized microbiota‐targeted approaches to improve clinical outcomes in
Zemin Tian, Yinde Huang, Ying Wang, Chenyu Zhao, Zhaokai Zhou, Hua Yang, Yuan Qiu   +6 more
wiley   +1 more source

Gaps Between European Crohn's Colitis Organisation Quality Standards of Care and the Real World in Special Situations in Inflammatory Bowel Disease Across Europe: Results From E‐QUALITY Survey

JCC Plus, Volume 1, Issue 1, January 2026.
ABSTRACT Background Managing special situations in Inflammatory Bowel Disease (IBD)—such as surgery, nutrition, acute severe ulcerative colitis (ASUC) and paediatric‐to‐adult transition—is critical for patient outcomes. The European Crohn's and Colitis Organisation's (ECCO) E‐QUALITY initiative aimed to identify gaps between its evidence‐based care ...
Gionata Fiorino, Catarina Fidalgo, Michel Adamina, Manuel Barreiro‐de Acosta, Mariam P. Ali, Martin Bortlik, Johan Burisch, Axel Dignass, David Drobne, Omar Faiz, Marc Ferrante, Liselotte Fierens, Lihi Godny, Anna Gojdicova, Marietta Iacucci, Susanna Jӓghult, Konstantinos Karmiris, Julien Kirchgesner, Sophie Restellini, Francesca Rosini, Dror Shouval, Henit Yanai, Edyta Zagórowicz, Alissa Walsh, on behalf of European Crohn's Colitis Organisation   +24 more
wiley   +1 more source