Results 41 to 50 of about 8,977 (151)

Tumor Infiltrating Lymphocyte Therapy Combined With PD‐1/LAG‐3 Inhibition in Patients With Recurrent Platinum‐Resistant Ovarian Cancer

International Journal of Cancer, EarlyView.
The detection of tumor‐infiltrating lymphocytes (TILs) is a positive prognostic factor in ovarian cancer. Moreover, TILs are significantly boosted by immunotherapy, though ovarian cancer patients have seen limited benefit from immune therapies. This study investigated the safety and feasibility of TIL therapy combined with PD‐1 and LAG‐3 inhibitors in ...
Tine J. Monberg, Cathrine L. Lorentzen, Marie C. W. Westergaard, Trine Z. Iversen, Troels H. Borch, Marco Donia, Sigrid M. Mannering, Stine E. W. Banke, Özcan Met, Inge Marie Svane   +9 more
wiley   +1 more source

Depleção de células intersticiais de Cajal no megacólon chagásico: a caminho do tratamento cirúrgico individualizado?

, 2010
BACKGROUND: The mechanism of constipation in patients with Chagasic megacolon remains partially explained. In these patients, it was recently demonstrated a reduction in the population of interstitial cells of Cajal.
Sylvio Figueiredo Bocchini, Sergio Carlos Nahas, NAHAS, Sergio Carlos, Viviane Rawet, ARAUJO, Sergio Eduardo Alonso, BOCCHINI, Sylvio Figueiredo, DUMARCO, Rodrigo Blanco, SEID, Victor Edmond, Victor Edmond Seid, RAWET, Viviane, Rodrigo Blanco Dumarco, Sergio Eduardo Alonso Araujo   +11 more
core   +1 more source

Long‐term outcomes of children with ulcerative colitis after acute severe colitis: A GETAID pédiatrique multicenter study

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Acute severe colitis (ASC) is a frequent and severe complication of ulcerative colitis (UC) with a high risk of colectomy. Effects of immunosuppressants and anti–tumor necrosis factor (anti‐TNF) agents on the risk of colectomy remain debated. We wished to study the evolution of French pediatric‐onset UC patients after ASC.
Manon Cochet, Agathe Beauvais, Frank Ruemmele, Raphael Enaud, Thierry Lamireau, Rémi Duclaux‐Loras, Claire Dupont, Stéphanie Willot, Laure Bridoux‐Henno, Georges Dimitrov, Julie Lemale, Vincent Guinard‐Samuel, Valérie Bertrand, Anne Breton, Christine Martinez Vinson, Stéphanie Coopman, Delphine Ley, Bénédicte Pigneur, and the Groupe d'Etudes Thérapeutiques des Affections Inflammatoires du tube Digestif (GETAID) pédiatrique   +18 more
wiley   +1 more source

Estudo estrutural dos componentes do sistema nervoso entérico e de células inflamatórias: uma contribuição a imunopatologia do megacólon chagásico. [PDF]

, 2007
A doença de Chagas é causada pelo parasita Tripanosoma cruzi, e dentre as suas várias manifestações clínicas, destacamos as alterações ocorridas no coração e no sistema digestivo.
Alexandre Barcelos Morais da Silveira
core  

Locked plate versus modified clamp‐rod internal fixation for feline corpus ilium fractures: A comparative clinical study

Veterinary Surgery, EarlyView.
Abstract Objective To evaluate the applicability and clinical effectiveness of a modified clamp‐rod internal fixation (M‐CRIF) system compared with conventional locking plate osteosynthesis in the treatment of feline corpus ilium fractures. Study design Prospective, controlled clinical study.
Nahit Saylak, Sadık Yayla, Semih Altan, Berna Ersöz‐Kanay, Emine Çatalkaya   +4 more
wiley   +1 more source

Treatment Outcomes of Hospitalized Patients With Inflammatory Bowel Disease at a Tertiary Care Center in Nepal: A Cross‐Sectional Study

JCC Plus, Volume 1, Issue 4, July 2026.
Overall, patients with IBD constituted 1.6% (n = 37) of all admissions to the gastroenterology ward for any indication. Most (2/3rd) hospitalized patients with IBD responded to conventional therapy; one third required advanced therapy or surgery. In‐hospital mortality was high at 5%, probably related to delayed diagnosis, limited access to advanced ...
Ajay Kumar Yadav, Bhupendra Kumar Basnet, Ramila Shrestha, Ajit Khanal, Milan Shrestha, Mukesh Sharma Poudel   +5 more
wiley   +1 more source

MEGACÓLON COM FORMAÇÃO DE FECALOMA POR OBSTRUÇÃO EXTRAMURAL EM FELINO

, 2020
O megacólon é definido como o aumento persistente e crônico do diâmetro colônico associado à constipação. A constipação pode evoluir para o fecaloma, o qual caracteriza-se pelo grande volume e endurecimento das fezes.
Dorneles Trindade, Natasha, de Oliveira Mendonça, Raphael   +1 more
core  

Surgical treatment of Chagas megacolon. Critical analysis of outcome in operative methods Tratamento cirúrgico do megacólon chagásico análise crítica dos resultados dos métodos operatórios [PDF]

, 2008
PURPOSE: Surgical treatment of chagasic megacolon has suffered innumerable transformations over the years. Poor knowledge of the disease physiopathology is one of the reasons.
José Joaquim Ribeiro da Rocha, GARCIA, Ricardo Luiz Santos, Bruna Meyer R. de Matos, FÉRES, Omar, Garcia,Ricardo Luiz Santos, Ricardo Luiz Santos Garcia, Féres,Omar, Matos,Bruna Meyer R. de, Omar Féres, ROCHA, José Joaquim Ribeiro da, MATOS, Bruna Meyer R. de, Rocha,José Joaquim Ribeiro da   +11 more
core   +1 more source

Colonic Dilatation Complicating Acute Severe Ulcerative Colitis Managed Successfully with Accelerated Infliximab Dosing

Case Reports in Gastroenterology, 2023
Lately, emerging data suggest an association between the development of inflammatory bowel disease and anti-interleukin-17 therapy. Megacolon is a life-threatening complication of acute severe ulcerative colitis (ASUC), but its treatment has not yet been
Hoang Huu Bui, Luan Minh Dang, Diem Thi-Ngoc Vo, Chuong Dinh Nguyen   +3 more
doaj   +1 more source

Regulation of PHOX2B gene expression by the long non‐coding natural antisense RNA PHOX2B‐AS1

The FEBS Journal, Volume 293, Issue 12, Page 3502-3527, June 2026.
PHOX2B is a transcription factor essential for autonomic nervous system development. We identify and characterize PHOX2B‐AS1, a human long non‐coding antisense transcript at the PHOX2B locus, along with its murine counterpart. Our findings reveal bidirectional transcription and reciprocal regulation: PHOX2B activates PHOX2B‐AS1, whereas PHOX2B‐AS1 ...
Simona Di Lascio, Ana Lucia Cuadros Gamboa, Martina Bertocchi, Filippo Chiesa, Francesca Cargnin, Ettore Mosca, Paride Pelucchi, Viviana Tritto, Stefania Corti, Isabella Ceccherini, Paola Riva, Roberta Benfante, Diego Fornasari   +12 more
wiley   +1 more source