Results 31 to 40 of about 8,948 (172)
International Journal of Cancer, Volume 159, Issue 7, Page 1735-1749, 1 October 2026.The detection of tumor‐infiltrating lymphocytes (TILs) is a positive prognostic factor in ovarian cancer. Moreover, TILs are significantly boosted by immunotherapy, though ovarian cancer patients have seen limited benefit from immune therapies. This study investigated the safety and feasibility of TIL therapy combined with PD‐1 and LAG‐3 inhibitors in ...
Tine J. Monberg +9 more
wiley +1 more source
Gut and Liver, 2015 Toxic megacolon is a rare clinical complication of fulminant Clostridium difficile infection. The mortality rate of fulminant C. difficile infection is reported to be as high as 50%.
doaj +1 more source
Neuropsychopharmacology Reports, Volume 46, Issue 3, September 2026.Synergistic “Double Brake” Model on the Spinal Defecation Center in Clozapine‐Induced Constipation. Real‐world data shows BZDRs increase laxative risk in schizophrenia. Mitigating the central GABAergic brake via sedative optimization and maintaining gut microbiota homeostasis prevents fatal Ogilvie's syndrome.
Takahiko Nagamine
wiley +1 more source
Enfermedad de Chagas y sus manifestaciones neurológicas
Acta Neurológica Colombiana, 2021 La enfermedad de chagas (tripanosomiasis americana) es una zoonosis potencialmente mortal causada por el parásito Trypanosoma cruzi, transmitido por vectores encontrados principalmente en territorio latinoamericano, aunque tiene otras vías de ...
Daniela Duque Montoya +1 more
doaj +1 more source
British Journal of Clinical Pharmacology, Volume 92, Issue 8, Page 2723-2740, August 2026.Aims Paediatric pharmacokinetics differ significantly from adults due to age‐related physiological changes, necessitating precise dose adjustments. However, data on therapeutic drug monitoring (TDM) implementation in paediatric setting remain limited.
Gianluca Gazzaniga +20 more
wiley +1 more source
Veterinary Surgery, Volume 55, Issue 6, Page 1133-1142, August 2026.Abstract Objective To evaluate the applicability and clinical effectiveness of a modified clamp‐rod internal fixation (M‐CRIF) system compared with conventional locking plate osteosynthesis in the treatment of feline corpus ilium fractures. Study design Prospective, controlled clinical study.
Nahit Saylak +4 more
wiley +1 more source
Frontiers in Medicine, 2018 In an interesting investigation by Khoury-Hanold et al. (1), genital infection of mice with herpes simplex virus 1 (HSV1) were reported to cause multiple pelvic organ involvement and obstruction.
Arun Chaudhury +14 more
doaj +1 more source
Pyridyl‐Imidazopyridine Derivatives Displaying Submicromolar Activity Against Trypanosoma cruzi
ChemMedChem, Volume 21, Issue 13, 14 July 2026.Previously reported pyridyl‐thiazoles and highly active imidazopyridines against Trypanosoma cruzi inspired the design of a new series of pyridyl‐substituted imidazopyridines. Among the synthesized compounds, 5h emerged as the most promising derivative, displaying potent trypanocidal activity (EC50 = 0.16 μM), excellent selectivity (SI > 1250), and ...
Ana Carolina Rocha Barreto +9 more
wiley +1 more source
Profile of interstitial cells of Cajal in a murine model of chagasic megacolon [PDF]
Anais da Academia Brasileira de CiênciasDisorders of gastrointestinal motility are the major physiologic problem in chagasic megacolon. The contraction mechanism is complex and controlled by different cell types such as enteric neurons, smooth muscle, telocytes, and an important pacemaker of ...
MAYRA FERNANDA RICCI +6 more
doaj +1 more source
British Journal of Clinical Pharmacology, Volume 92, Issue 7, Page 2162-2170, July 2026.Aims Ocrelizumab is a humanized anti‐CD20 monoclonal antibody used in multiple sclerosis. Since its commercialization, several cases of ocrelizumab‐induced colitis have been reported in the scientific literature. Methods To explore the potential association of ocrelizumab with colitis as an adverse drug reaction (ADR), we conducted a descriptive and ...
Audrey Fresse +3 more
wiley +1 more source