Results 31 to 40 of about 10,441 (212)

Therapeutic drug monitoring of antimicrobials in a paediatric setting: A retrospective single‐centre study

British Journal of Clinical Pharmacology, EarlyView.
Aims Paediatric pharmacokinetics differ significantly from adults due to age‐related physiological changes, necessitating precise dose adjustments. However, data on therapeutic drug monitoring (TDM) implementation in paediatric setting remain limited.
Gianluca Gazzaniga, Stefano Agliardi, Riccardo Giossi, Alice Schianchi, Alessandra Romandini, Thomas Virdis, Silvia Nerini Molteni, Maria Luisa De Angelis, Stefania Paccagnini, Cecilia Gechtman, Alice Proto, Marco Fossati, Silvia Oliveri, Giulia Angela Pattarino, Elena Altieri, Agnese Graziosi, Arianna Pani, Romano Danesi, Stefano Martinelli, Costantino De Giacomo, Francesco Scaglione   +20 more
wiley   +1 more source

Atresia anal tipo III com presença de fístula vaginal e megacólon: Relato de caso

Pubvet, 2018
O presente relato de caso tem como objetivo apresentar um caso de atresia anal tipo III, com megacólon e fistula vaginal em cão sem raça definida. A técnica cirúrgica utilizada e a conduta pós cirúrgica com a realização de enemas diários e hidratação foi
Tairine Melo Costa, Samuel Otemi de Sousa Silva, Thamara Barrozo Sampaio, Daniele Benigno Mota, Vanessa Brígida Pinheiro Rodrigues, Jéssica Maria da Silva Sousa, Aline Silva Santos, Ana Gabriela Pereira Moura Leite   +7 more
doaj   +1 more source

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source

Successfully Treated Pediatric Patient With Megarectum by Vertical Reduction Rectoplasty [PDF]

Iranian Journal of Colorectal Research, 2014
This report represents successful treatment of a seven-year-old boy with megarectum, who complained of intractable constipation and encopresis, by vertical reduction rectoplasty.
Ibrahim Akkoyun
doaj   +1 more source

Tumor Infiltrating Lymphocyte Therapy Combined With PD‐1/LAG‐3 Inhibition in Patients With Recurrent Platinum‐Resistant Ovarian Cancer

International Journal of Cancer, EarlyView.
The detection of tumor‐infiltrating lymphocytes (TILs) is a positive prognostic factor in ovarian cancer. Moreover, TILs are significantly boosted by immunotherapy, though ovarian cancer patients have seen limited benefit from immune therapies. This study investigated the safety and feasibility of TIL therapy combined with PD‐1 and LAG‐3 inhibitors in ...
Tine J. Monberg, Cathrine L. Lorentzen, Marie C. W. Westergaard, Trine Z. Iversen, Troels H. Borch, Marco Donia, Sigrid M. Mannering, Stine E. W. Banke, Özcan Met, Inge Marie Svane   +9 more
wiley   +1 more source

Infliximab in Crohn's disease-associated toxic megacolon

, 2012
Item does not contain fulltextRefractory medical treatment of Crohn disease-associated toxic megacolon usually requires surgery, which carries substantial morbidity and mortality.
Geenen, E.J.M. van, van Geenen, E.M., Erwin-Jan M. van Geenen, Sachar, D.B., David B. Sachar   +4 more
core   +1 more source

Long‐term outcomes of children with ulcerative colitis after acute severe colitis: A GETAID pédiatrique multicenter study

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Acute severe colitis (ASC) is a frequent and severe complication of ulcerative colitis (UC) with a high risk of colectomy. Effects of immunosuppressants and anti–tumor necrosis factor (anti‐TNF) agents on the risk of colectomy remain debated. We wished to study the evolution of French pediatric‐onset UC patients after ASC.
Manon Cochet, Agathe Beauvais, Frank Ruemmele, Raphael Enaud, Thierry Lamireau, Rémi Duclaux‐Loras, Claire Dupont, Stéphanie Willot, Laure Bridoux‐Henno, Georges Dimitrov, Julie Lemale, Vincent Guinard‐Samuel, Valérie Bertrand, Anne Breton, Christine Martinez Vinson, Stéphanie Coopman, Delphine Ley, Bénédicte Pigneur, and the Groupe d'Etudes Thérapeutiques des Affections Inflammatoires du tube Digestif (GETAID) pédiatrique   +18 more
wiley   +1 more source

Case Report: Anal canal duplication associated with anorectal stenosis—A rare presentation

Frontiers in Pediatrics, 2022
Anal canal duplication is a rare gastrointestinal malformation characterized by extra anal orifices at 6 o'clock in the lithotomy position. To date, there have been only 110 reported cases. The purpose of this study is to contribute two infant cases, one
Zhen Zheng, Zhen Zheng, Dong Xiao, Junxiang Wang, Haozhong Xu, Jianxiong Mao, Xiuliang Wang   +6 more
doaj   +1 more source

Locked plate versus modified clamp‐rod internal fixation for feline corpus ilium fractures: A comparative clinical study

Veterinary Surgery, EarlyView.
Abstract Objective To evaluate the applicability and clinical effectiveness of a modified clamp‐rod internal fixation (M‐CRIF) system compared with conventional locking plate osteosynthesis in the treatment of feline corpus ilium fractures. Study design Prospective, controlled clinical study.
Nahit Saylak, Sadık Yayla, Semih Altan, Berna Ersöz‐Kanay, Emine Çatalkaya   +4 more
wiley   +1 more source

Campylobacter colitis: Rare cause of toxic megacolon

, 2016
IntroductionCampylobacter is the leading cause of bacterial diarrhoeal illness worldwide. Toxic megacolon is a rare but potentially devastating complication.Presentation of caseA 55year old female with liver cirrhosis, alcoholism and hepatitis C ...
Kwok, Michael, Maurice, Andrew, Lisec, Carl, Brown, Jason   +3 more
core   +1 more source