Results 41 to 50 of about 10,441 (212)

A Case of Toxic Megacolon Caused by Clostridium difficile Infection and Treated with Fecal Microbiota Transplantation

Gut and Liver, 2015
Toxic megacolon is a rare clinical complication of fulminant Clostridium difficile infection. The mortality rate of fulminant C. difficile infection is reported to be as high as 50%.
doaj   +1 more source

Ocrelizumab‐induced colitis: VigiBase disproportionality analysis, case reports and literature review

British Journal of Clinical Pharmacology, Volume 92, Issue 7, Page 2162-2170, July 2026.
Aims Ocrelizumab is a humanized anti‐CD20 monoclonal antibody used in multiple sclerosis. Since its commercialization, several cases of ocrelizumab‐induced colitis have been reported in the scientific literature. Methods To explore the potential association of ocrelizumab with colitis as an adverse drug reaction (ADR), we conducted a descriptive and ...
Audrey Fresse, Christophe Hommel, Nadine Petitpain, Philippe Kerschen   +3 more
wiley   +1 more source

Idiopathic Megacolon—Short Review

, 2021
Introduction: Idiopathic megacolon (IM) is a rare condition with a more or less known etiology, which involves management challenges, especially therapeutic, and both gastroenterology and surgery services.
Bogdan Socea, Dragos Predescu, Dan Spinu, Adrian Constantin, Florin Achim   +4 more
core   +1 more source

Treatment Outcomes of Hospitalized Patients With Inflammatory Bowel Disease at a Tertiary Care Center in Nepal: A Cross‐Sectional Study

JCC Plus, Volume 1, Issue 4, July 2026.
Overall, patients with IBD constituted 1.6% (n = 37) of all admissions to the gastroenterology ward for any indication. Most (2/3rd) hospitalized patients with IBD responded to conventional therapy; one third required advanced therapy or surgery. In‐hospital mortality was high at 5%, probably related to delayed diagnosis, limited access to advanced ...
Ajay Kumar Yadav, Bhupendra Kumar Basnet, Ramila Shrestha, Ajit Khanal, Milan Shrestha, Mukesh Sharma Poudel   +5 more
wiley   +1 more source

HSV1/2 Genital Infection in Mice Cause Reversible Delayed Gastrointestinal Transit: A Model for Enteric Myopathy

Frontiers in Medicine, 2018
In an interesting investigation by Khoury-Hanold et al. (1), genital infection of mice with herpes simplex virus 1 (HSV1) were reported to cause multiple pelvic organ involvement and obstruction.
Arun Chaudhury, Vijaya Sena Reddy Dendi, Mousumi Chaudhury, Astha Jain, Madhukar Reddy Kasarla, Kiran Panuganti, Gaurav Jain, Abhijit Ramanujam, Bhavin Rena, Sudheer Reddy Koyagura, Sumit Fogla, Sunil Kumar, Nawal Singh Shekhawat, Srinivas Maddur, Srinivas Maddur   +14 more
doaj   +1 more source

Regulation of PHOX2B gene expression by the long non‐coding natural antisense RNA PHOX2B‐AS1

The FEBS Journal, Volume 293, Issue 12, Page 3502-3527, June 2026.
PHOX2B is a transcription factor essential for autonomic nervous system development. We identify and characterize PHOX2B‐AS1, a human long non‐coding antisense transcript at the PHOX2B locus, along with its murine counterpart. Our findings reveal bidirectional transcription and reciprocal regulation: PHOX2B activates PHOX2B‐AS1, whereas PHOX2B‐AS1 ...
Simona Di Lascio, Ana Lucia Cuadros Gamboa, Martina Bertocchi, Filippo Chiesa, Francesca Cargnin, Ettore Mosca, Paride Pelucchi, Viviana Tritto, Stefania Corti, Isabella Ceccherini, Paola Riva, Roberta Benfante, Diego Fornasari   +12 more
wiley   +1 more source

Profile of interstitial cells of Cajal in a murine model of chagasic megacolon [PDF]

Anais da Academia Brasileira de Ciências
Disorders of gastrointestinal motility are the major physiologic problem in chagasic megacolon. The contraction mechanism is complex and controlled by different cell types such as enteric neurons, smooth muscle, telocytes, and an important pacemaker of ...
MAYRA FERNANDA RICCI, ANA L. MAZZETI, JOANA L. BARBOSA, FABIANA S. MACHADO, MARIA TEREZINHA BAHIA, ROSA MARIA E. ARANTES, SAMANTHA R. SOUZA   +6 more
doaj   +1 more source

Genetic Identification of Potential Drug Targets for Dental Caries: A Mendelian Randomization Study

Health Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background and Aims Dental caries (DC), a chronic and multifactorial disease, affects billions of people globally, posing a significant public health challenge. Despite its prevalence, the molecular mechanisms underlying DC and effective pharmacological targets remain elusive.
Junlei Bi, Anqi Liu, Na Zhang, Yuxin Chen, Changqing Liu, Yongna Zhu, Hebao Wen, Caiyun Ma   +7 more
wiley   +1 more source

A Case of Fulminant Immune‐Related Enterocolitis During Immune Checkpoint Inhibitor Therapy for Metastatic Renal Cell Carcinoma

IJU Case Reports, Volume 9, Issue 3, May 2026.
ABSTRACT Introduction Combination therapy with immune checkpoint inhibitors (ICIs) has become a standard treatment for metastatic renal cell carcinoma (mRCC). However, ICIs may also cause immune‐related adverse events. We report a case of mRCC that developed fulminant immune‐related enterocolitis.
Kasumi Kanai, Takayuki Sumiyoshi, Hiroki Kitamoto, Yuki Teramoto, Yuta Mine, Jin Kono, Kimihiko Masui, Takayuki Goto, Ryoichi Saito, Takashi Kobayashi   +9 more
wiley   +1 more source

Laparoscopic treatment of acquired megacolon

, 2014
In spite of the large experience acquired in the last 50 years with the surgical treatment of the Chagasic megacolon, the use of colorectal video laparoscopic surgery brought some controversy in several aspects of the treatment that already had been ...
JA,Reis Neto, Banci SO, LH,Oliveira, JA, Reis Neto, SO, Banci, O, Kagohara, J,Simões Neto, J, Simões Neto, O,Kagohara, Reis Junior JA, Kagohara O, SO,Banci, LH, Oliveira, JA,Reis Junior, Reis Neto JA, JA, Reis Junior, Oliveira LH, Simões Neto J   +17 more
core   +1 more source