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Effects of Anagrelide on Megakaryopoiesis and Platelet Production
Seminars in Thrombosis and Hemostasis, 2006Possible pathomechanisms regarding the thromboreductive effect of anagrelide (ANA) include decrease in the megakaryocyte cell mass or life span of platelets, interference with maturation, and stimulation of apoptosis and proliferation. Finally, a fibrogenic effect has been reported in patients with high-risk essential thrombocythemia (ET).
Thiele, Juergen +2 more
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Modulation of megakaryopoiesis and platelet production during inflammation.
Thrombosis Research, 2019Megakaryocytes (MKs) are widely known as the progenitor cells of platelets. These large, polyploid cells are a derivative of the hematopoietic stem cell (HSC), and reside in the bone marrow, lining blood vessel walls where they release their platelet ...
Genevieve C Couldwell, K. Machlus
semanticscholar +1 more source
A functional role of Stat3 in in vivo megakaryopoiesis
Blood, 2002AbstractThe signal transducer and activator of transcription 3 (Stat3), a member of the Stat family of proteins, is commonly activated by thrombopoietic cytokines including thrombopoietin (TPO), interleukin (IL)-6, and interleukin-11. This finding strongly suggested that Stat3 has an important role in megakaryopoiesis and thrombopoiesis. To clarify the
Keita, Kirito +11 more
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Contemporaneous Illustration of Megakaryopoiesis
Indian Journal of Hematology and Blood Transfusion, 2023Nishit Gupta +3 more
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Megakaryopoiesis and Platelet Biogenesis
2016Blood platelets are 2–3 um anucleate fragments that are formed from the megakaryocyte cytoplasm and have a distinctive discoid shape. To generate and release platelets, megakaryocytes undergo endomitosis to become polyploid and follow a maturation program that results in the transformation of the bulk of their cytoplasm into multiple long processes ...
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[Proliferation and differentiation in megakaryopoiesis].
Verhandlungen der Deutschen Gesellschaft fur Pathologie, 1991Megakaryocytic progenitor cells only complete a limited number of mitotic events; early in megakaryopoiesis, these cells loose their capacity for cell division and acquire the ability for endoreduplication--a phenomenon that is unique to the megakaryocytic lineage.
L, Kanz, R, Mertelsmann
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[New aspects of megakaryopoiesis].
Wiener klinische Wochenschrift, 1984Like erythro- and granulopoiesis megakaryocytopoiesis (MK poiesis) is controlled by specific feed-back mechanisms. Platelet production has been found to be regulated predominantly by the number or mass of circulating platelets. Our present understanding of MK poiesis is based on data from 3 major experimental areas, which are individually discussed in ...
D, Geissler, C, Peschel, G, Konwalinka
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ABNORMAL MEGAKARYOPOIESIS IN ACUTE LEUKAEMIA
British Journal of Haematology, 1988C, Hoyle, F G, Hayhoe
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Cholinergic drugs inhibit in vitro megakaryopoiesis via the alpha7-nicotinic acetylcholine receptor
Platelets, 2011Peter Bugert, Harald Klüter
exaly