Results 161 to 170 of about 7,888 (191)

Megakaryopoiesis disturbances in atherosclerotic rabbits

Atherosclerosis, 1987
Rabbits given a hypercholesterolemic diet (500 mg/day) for 6 months and then maintained for another 6 months on a normal diet were found to have developed fibrous lipidic lesions in the aorta. Although circulating platelet levels in these animals were normal there was a reduction in mean megakaryocyte ploidy.
H, Dupont, M A, Dupont, J, Larrue, M R, Boisseau, H, Bricaud   +4 more
openaire   +2 more sources

Megakaryopoiesis in patients with cyclic thrombocytopenia

British Journal of Haematology, 1995
Summary Megakaryopoiesis was examined in 10 patients (eight females and two males) with cyclic thrombocytopenia (CT) to investigate the underlying pathogenesis. Numbers of CFU‐Meg and megakaryocytes and the mean cytoplasmic area (mean area) of megakaryocytes at the peak, nadir, ascent mid phase, and descent mid phase of the platelet cycle were ...
T, Nagasawa, Y, Hasegawa, M, Kamoshita, K, Ohtani, T, Komeno, T, Itoh, A, Shinagawa, H, Kojima, H, Ninomiya, T, Abe   +9 more
openaire   +2 more sources

Molecular Control of Megakaryopoiesis and Thrombopoiesis

International Journal of Hematology, 2002
Megakaryopoiesis and subsequent thrombopoiesis occur through complex biologic steps: megakaryocyte precursors that developed from hematopoietic stem cells initially proliferate, then differentiate into mature polyploid megakaryocytes, and finally release platelets.
Itaru, Matsumura, Yuzuru, Kanakura
openaire   +2 more sources

Megakaryopoiesis and Thrombopoiesis

2017
Platelets are formed from the cytoplasm of megakaryocytes (MKs) that reside in the bone marrow (BM). MKs arise from hematopoietic stem cells in the osteoblastic niche in BM. The primary regulator of megakaryopoiesis is thrombopoietin. It is generally accepted that MKs migrate into the vascular niche and produce platelets; however, the mechanism by ...
Shugo Kowata, Yoji Ishida
openaire   +1 more source

Biphasic Effect of Thyroid Hormone on Megakaryopoiesis and Platelet Production

Thyroid
Background: Abnormal platelet counts are frequently observed in patients with thyroid dysfunction; however, the direct impact of thyroid hormones on thrombopoiesis remains largely undefined.
Bai-Chuan Xu, Xianpeng Ye, Zhaoyang Wen, Jun Chen, Mo Chen, Ming-Qiang Shen, Yang Xu, Jun-Ping Wang, Shilei Chen   +8 more
semanticscholar   +1 more source

Microvesicles promote megakaryopoiesis by regulating DNA methyltransferase and methylation of Notch1 promoter

Journal of Cellular Physiology, 2020
Megakaryopoiesis is the process of formation of mature megakaryocytes that takes place in the bone marrow niche resulting in the release of platelets into the peripheral blood.
Saran Chattapadhyaya, Srijan Haldar, S. Banerjee   +2 more
semanticscholar   +1 more source

Nanocurcumin as a novel stimulator of megakaryopoiesis that ameliorates chemotherapy-induced thrombocytopenia in mice.

Life Science, 2020
AIMS Platelet production improvement can resolve concerns about the limitations of external platelet supply and platelet transfusion in thrombocytopenia patients.
S. M. Farsani, M. Sadeghizadeh, M. Gholampour, Z. Safari, F. Najafi   +4 more
semanticscholar   +1 more source

Megakaryopoiesis: Transcriptional Insights into Megakaryocyte Maturation

Frontiers in Bioscience, 2007
Platelets are small anucleate cells that travel near the vessel wall during laminar flow. In response to vascular injury, platelets undergo alterations in morphology which allow them to aggregate and cover the injured site. Platelets are produced by megakaryocytes in a process that involves the formation of platelet precursors called proplatelets and ...
John Creigh, Kostyak, Ulhas Pandurang, Naik   +1 more
openaire   +2 more sources

ABC transporters in megakaryopoiesis and platelet activity

Thrombosis Research, 2017
ATP-binding cassette (ABC) is a family of transporters that facilitates the translocation of substrates across cell membrane using its ATPase subunit. These transporters have key roles in multidrug resistance, lipid homeostasis, antigen processing, immunity, cell proliferation and hematopoiesis.
Wei, Wang, Lorena, Buitrago, Ying, Wang
openaire   +2 more sources

BUBR1 deficiency results in abnormal megakaryopoiesis

Blood, 2003
The physiologic function of BUBR1, a key component of the spindle checkpoint, was examined by generating BUBR1-mutant mice. BUBR1(-/-) embryos failed to survive beyond day 8.5 in utero as a result of extensive apoptosis. Whereas BUBR1(+/-) blastocysts grew relatively normally in vitro, BUBR1(-/-) blastocysts exhibited impaired proliferation and ...
Qi, Wang, Tongyi, Liu, Yuqiang, Fang, Suqing, Xie, Xuan, Huang, Radma, Mahmood, Gita, Ramaswamy, Kathleen M, Sakamoto, Zbigniew, Darzynkiewicz, Ming, Xu, Wei, Dai   +10 more
openaire   +2 more sources