Results 151 to 160 of about 7,888 (191)
Some of the next articles are maybe not open access.
Reviews in Medical Virology
Megakaryopoiesis is a complex biological process through which haematopoietic stem cells differentiate into megakaryocyte, leading to the formation of platelets.
Bhupendra Kumar Verma, Riya Roy
exaly +2 more sources
Megakaryopoiesis is a complex biological process through which haematopoietic stem cells differentiate into megakaryocyte, leading to the formation of platelets.
Bhupendra Kumar Verma, Riya Roy
exaly +2 more sources
Rapamycin and bafilomycin A1 alter autophagy and megakaryopoiesis
Platelets, 2017 Autophagy is an effective strategy for cell development by recycling cytoplasmic constituents. Genetic deletion of autophagy mediator Atg7 in hematopoietic stem cells (HSCs) can lead to failure of megakaryopoiesis and enhanced autophagy has been ...
Mortimer Poncz, Li Zhu, Tao You
exaly +2 more sources
European Journal of Pharmacology, 2023
Radiation-induced thrombocytopenia (RIT) occurs widely and causes high mortality and morbidity in cancer patients who receive radiotherapy. However, specific drugs for treating RIT remain woefully inadequate.
Ting Zhang +14 more
semanticscholar +1 more source
Radiation-induced thrombocytopenia (RIT) occurs widely and causes high mortality and morbidity in cancer patients who receive radiotherapy. However, specific drugs for treating RIT remain woefully inadequate.
Ting Zhang +14 more
semanticscholar +1 more source
Pharmacological Research, 2022
Thrombocytopenia, a most common complication of radiotherapy and chemotherapy, is an important cause of morbidity and mortality in cancer patients. However, there are still no approved agents for the treatment of radiation- and chemotherapy-induced ...
Long Wang +13 more
semanticscholar +1 more source
Thrombocytopenia, a most common complication of radiotherapy and chemotherapy, is an important cause of morbidity and mortality in cancer patients. However, there are still no approved agents for the treatment of radiation- and chemotherapy-induced ...
Long Wang +13 more
semanticscholar +1 more source
Interferon regulatory factor-2 induces megakaryopoiesis in mouse bone marrow hematopoietic cells [PDF]
FEBS Letters, 2009 Megakaryopoiesis is associated with inflammatory reactions. To investigate the role of interferon regulatory factors (IRFs) in inflammation-associated megakaryopoiesis, mouse bone marrow hematopoietic stem cells (HSCs) were analyzed.
Takuo Mizukami +2 more
exaly +2 more sources
MEIS1 Regulates Hemogenic Endothelial Generation, Megakaryopoiesis, and Thrombopoiesis in Human Pluripotent Stem Cells by Targeting TAL1 and FLI1 [PDF]
Stem Cell Reports, 2018 Summary: Human pluripotent stem cells (hPSCs) provide an unlimited source for generating various kinds of functional blood cells. However, efficient strategies for generating large-scale functional blood cells from hPSCs are still lacking, and the ...
Lihong Shi, Mengge Wang, Jie Gao
exaly +2 more sources
Interferon-γ and Human Megakaryopoiesis
Leukemia and Lymphoma, 1998Interferon-gamma (IFN-gamma) exhibits various properties including antigrowth activity in neoplastic and normal cells and regulatory roles in immune responses and hematopoiesis, but studies of IFN-gamma effects on human megakaryopoiesis have been inconclusive.
Tatsutoshi Nakahata +2 more
exaly +3 more sources
Neonatal and adult megakaryopoiesis
Current Opinion in Hematology, 2011It has become increasingly clear that there are substantial biological differences between fetal/neonatal and adult megakaryopoiesis. Over the last 18 months, studies challenged the paradigm that neonatal megakaryocytes are immature and revealed a developmentally unique uncoupling of proliferation, polyploidization, and cytoplasmic maturation.
Zhi-Jian, Liu, Martha, Sola-Visner
openaire +2 more sources
Molecular mechanisms of megakaryopoiesis
Cellular and Molecular Life Sciences, 2006One function of bone marrow megakaryocytes (MKs) is the controlled release of platelets into the circulation. Over the past few years, molecular mechanisms that contribute to MK development and differentiation have begun to be elucidated. This review provides a brief overview of megakaryopoiesis and platelet function, and the importance of selected ...
G, Szalai, A C, LaRue, D K, Watson
openaire +2 more sources
Phytomedicine, 2022
BACKGROUND Thrombocytopenia (TP) remains a challenge in clinical hematology. TP may have serious consequences, such as recurrent skin and mucosal bleeding and increased risk of intracranial and internal organ hemorrhage.
Yaqi Kang +10 more
semanticscholar +1 more source
BACKGROUND Thrombocytopenia (TP) remains a challenge in clinical hematology. TP may have serious consequences, such as recurrent skin and mucosal bleeding and increased risk of intracranial and internal organ hemorrhage.
Yaqi Kang +10 more
semanticscholar +1 more source