Results 131 to 140 of about 4,363 (174)

The Role of Megakaryocyte Assessment in Bone Marrow Cytology. [PDF]

J Clin Med
Błocka-Gumowska M, Hus I, Szymczyk A.
europepmc   +1 more source

Paediatric Acute Myeloid Leukaemia-Myelodysplasia Related With i(17)(q10) Morphologically Mimicking Acute Promyelocytic Leukaemia. [PDF]

EJHaem
De John K, Koen JE, De Quintal H, Lohlun R.   +3 more
europepmc   +1 more source

Cullin-5 controls the number of megakaryocyte-committed stem cells to prevent thrombocytosis in mice.

Blood
Kauppi M, Hyland CD, Viney EM, White CA, de Graaf CA, Welch AE, Yousef J, Dagley LF, Emery-Corbin SJ, Di Rago L, Kueh AJ, Herold MJ, Hilton DJ, Babon JJ, Nicola NA, Behrens K, Alexander WS.   +16 more
europepmc   +1 more source

Ontogeny drives stage-specific effects of a Gata1 mutation

Sommer A, Fischer S, Freyer L, Lallemand Y, Dardenne P, Gomez Perdiguero E.   +5 more
europepmc   +1 more source

Role of Rho-GTPases in megakaryopoiesis [PDF]

Small GTPases, 2021
Megakaryocytes (MKs) are the bone marrow (BM) cells that generate blood platelets by a process that requires: i) polyploidization responsible for the increased MK size and ii) cytoplasmic organization leading to extension of long pseudopods, called proplatelets, through the endothelial barrier to allow platelet release into blood.
William Vainchenker, Larissa Lordier, Najet Debili   +2 more
exaly   +3 more sources

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Cytokine control of megakaryopoiesis

Growth Factors, 2018
Platelets are anuclear blood cells required for haemostasis and are implicated in other processes including inflammation and metastasis. Platelets are produced by megakaryocytes, specialized cells that are themselves generated by a process of controlled differentiation and maturation of bone-marrow stem and progenitor cells.
Kira Behrens
exaly   +3 more sources

Fetal vs adult megakaryopoiesis

Blood, 2022
Abstract Fetal and neonatal megakaryocyte progenitors are hyperproliferative compared with adult progenitors and generate a large number of small, low-ploidy megakaryocytes. Historically, these developmental differences have been interpreted as “immaturity.” However, more recent studies have demonstrated that the small, low-ploidy fetal ...
Patricia Davenport, Zhi-Jian Liu, Martha Sola-Visner   +2 more
openaire   +2 more sources

Neonatal and adult megakaryopoiesis

Current Opinion in Hematology, 2011
It has become increasingly clear that there are substantial biological differences between fetal/neonatal and adult megakaryopoiesis. Over the last 18 months, studies challenged the paradigm that neonatal megakaryocytes are immature and revealed a developmentally unique uncoupling of proliferation, polyploidization, and cytoplasmic maturation.
Zhi-Jian, Liu, Martha, Sola-Visner
openaire   +2 more sources

Molecular mechanisms of megakaryopoiesis

Cellular and Molecular Life Sciences, 2006
One function of bone marrow megakaryocytes (MKs) is the controlled release of platelets into the circulation. Over the past few years, molecular mechanisms that contribute to MK development and differentiation have begun to be elucidated. This review provides a brief overview of megakaryopoiesis and platelet function, and the importance of selected ...
G, Szalai, A C, LaRue, D K, Watson
openaire   +2 more sources