Results 41 to 50 of about 12,780 (229)

Outcome parameters in studies investigating dry eye disease: A systematic literature review

Acta Ophthalmologica, EarlyView.
Abstract The development of effective therapeutics for dry eye disease (DED) is challenging due to its complex pathophysiology, heterogeneous patient presentation and the significant failure rate of previous clinical development programs. This underlines the importance of the selection of appropriate endpoints for clinical trials.
Viktoria Pai, Doreen Schmidl, Liudmyla Petric, Patrick Janku, Theresa Lindner, Ulrich Graf, Jacqueline Chua, Leopold Schmetterer, Gerhard Garhöfer   +8 more
wiley   +1 more source

Meibomian gland imaging: A review

African Vision and Eye Health, 2015
The meibomian glands of the upper and lower eyelids play a valuable role in secreting the lipidlayer of the tear film. Disturbances in meibomian gland function may result in altered secretion andvariations in tear composition which may lead to meibomian ...
Deanne L. Nicholas, Wayne D.H. Gillan
doaj   +1 more source

What is the incidence and clinical significance of dry eye disease in patients treated with immune checkpoint inhibitors? A systematic review and meta‐analysis of ocular immune‐related adverse events

Acta Ophthalmologica, EarlyView.
Abstract Purpose Immune checkpoint inhibitors (ICIs) have transformed cancer therapy but may cause immune‐related adverse events (irAEs), including dry eye disease (DED). This study aimed to quantify the incidence of ICI‐associated DED and to evaluate factors contributing to variability across studies.
Kai‐Yang Chen, Hoi‐Chun Chan, Chi‐Ming Chan   +2 more
wiley   +1 more source

Interpretation of the group standard for operation procedure of meibomian gland massage

Yanke Xuebao
Meibomian gland dysfunction (MGD) can lead to an imbalance in the ocular surface microenvironment,eye discomfortable, and visual impairment, thereby profoundly affecting the visual quality of life of patients.Meibomian gland massage is now widely used in
TIAN Bishan, LI Shuping, FU Qi, DENG Yuqing, XIAO Bing, YUAN Jin   +5 more
doaj   +1 more source

The Relationship of Lid Wiper Epitheliopathy to Ocular Surface Signs and Symptoms. [PDF]

, 2018
Purpose:There has been interest in determining whether lid wiper epitheliopathy (LWE) plays a key role in causing ocular discomfort. Conflicting reports have made it difficult to discern whether LWE is more prevalent in certain populations, what ...
Lerma, Mariel, Leung, Tiana, Li, Wing, Lin, Meng C, Yeh, Thao N, Yuen, Tiffany   +5 more
core   +1 more source

Repeatability of keratometry depending on tear film osmolarity

Acta Ophthalmologica, EarlyView.
Abstract Purpose To determine the repeatability of keratometry and astigmatism measurements of patients depending on the tear film osmolarity using three different devices. Methods In this study, 97 eyes of 97 patients with a mean age of 64.92 ± 12.07 years received three repeated measurements with the IOLMaster 700 (Carl Zeiss Meditec, Jena, Germany),
David Schneider, Klemens Paul Kaiser, Petra Davidova, Thomas Kohnen, Tyll Jandewerth   +4 more
wiley   +1 more source

Dry eye disease symptoms and associated risk factors in a Norwegian clinical cohort

Acta Ophthalmologica, EarlyView.
Abstract Background The relationship between dry eye disease (DED) symptoms and different demographic, clinical and lifestyle factors remains poorly understood. Norway's cold climate and dry indoor air may accelerate tear evaporation, contributing to a very high meibomian gland dysfunction prevalence, as found in multiple studies.
Mazyar Yazdani, Fredrik A. Fineide, Reza A. Badian, Ayyad Zartasht Khan, Helge Rootwelt, Jan Terje Kvaløy, Tor Paaske Utheim   +6 more
wiley   +1 more source

Evaluation of a rat meibomian gland dysfunction model induced by closure of meibomian gland orifices [PDF]

International Journal of Ophthalmology, 2018
AIM: To find a stable, inexpensive, and reliable method to produce a rat meibomian gland dysfunction (MGD) model. METHODS: We inserted slim guidewires into the meibomian gland orifices of twelve Brown Norway rats and fulgurized every guidewire to ...
Zi-Yi Dong, Ming Ying, Jie Zheng, Lan-Jun Hu, Jiang-Yan Xie, Yi Ma   +5 more
doaj   +1 more source

Agreement in dry eye management between optometrists and general practitioners in primary health care in the Netherlands [PDF]

, 2015
The final publication is available at Elsevier via http://dx.doi.org/10.1016/j.clae.2015.03.005 © 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/Purpose: To investigate ...
Evans, Katharine S.E., Murphy, Paul J., Van Tilborg, Mirjam M.   +2 more
core   +1 more source

Evolving treatments for Sjögren disease: current approaches and emerging targets

Internal Medicine Journal, EarlyView.
Abstract Sjögren disease (SjD) is a prevalent systemic autoimmune condition characterised by exocrine gland dysfunction, systemic inflammation and heterogeneous organ involvement. Current management remains largely symptomatic, with no approved disease‐modifying therapies available and substantial unmet clinical need. However, advances in understanding
Mansi Bhurani, Adrian Y. S. Lee, Maureen Rischmueller, Alberta Hoi   +3 more
wiley   +1 more source