Results 31 to 40 of about 5,436 (176)

What is the incidence and clinical significance of dry eye disease in patients treated with immune checkpoint inhibitors? A systematic review and meta‐analysis of ocular immune‐related adverse events

Acta Ophthalmologica, EarlyView.
Abstract Purpose Immune checkpoint inhibitors (ICIs) have transformed cancer therapy but may cause immune‐related adverse events (irAEs), including dry eye disease (DED). This study aimed to quantify the incidence of ICI‐associated DED and to evaluate factors contributing to variability across studies.
Kai‐Yang Chen, Hoi‐Chun Chan, Chi‐Ming Chan   +2 more
wiley   +1 more source

Dry eye disease symptoms and associated risk factors in a Norwegian clinical cohort

Acta Ophthalmologica, EarlyView.
Abstract Background The relationship between dry eye disease (DED) symptoms and different demographic, clinical and lifestyle factors remains poorly understood. Norway's cold climate and dry indoor air may accelerate tear evaporation, contributing to a very high meibomian gland dysfunction prevalence, as found in multiple studies.
Mazyar Yazdani, Fredrik A. Fineide, Reza A. Badian, Ayyad Zartasht Khan, Helge Rootwelt, Jan Terje Kvaløy, Tor Paaske Utheim   +6 more
wiley   +1 more source

Modern Ideas about Dysfunction of the Meibomian Glands

Oftalʹmologiâ, 2022
Purpose: to develop a comprehensive method of meibomian gland dysfunction (MGD) treatment, including the periorbital zone massage, aimed to improving the microcirculation of the eyelids and the functional activity of the meibomian glands, evaluating its ...
I. B. Medvedev, V. N. Trubilin, E. G. Poluninа, N. N. Dergacheva, D. V. Andzhelova, Yu. V. Evstigneeva, K. V. Chinenova   +6 more
doaj   +1 more source

Efficacy and safety of topical macrolides versus systemic tetracyclines for meibomian gland dysfunction–a systematic review and meta‐analysis

Acta Ophthalmologica, EarlyView.
Abstract Purpose To review the efficacy and safety of oral doxycycline antibiotics versus topical macrolides in the treatment of meibomian gland dysfunction (MGD). Design Systematic review and meta‐analysis. Methods A comprehensive search of PubMed, Scopus, Embase, and ClinicalTrials.gov through December 2024 identified randomised controlled trials ...
Margarita Safir, Clara C. Chan, Joshua C. Teichman, Itamar Arbel, Ruth Lapid‐Gortzak, Camiel J. F. Boon, Michael Mimouni, Dror Ben Ephraim Noyman   +7 more
wiley   +1 more source

Characteristics of tear film lipid layer in young dry eye patients

Journal of the Formosan Medical Association, 2021
Background/Purpose: To investigate the characteristics of subjective symptoms and objective parameters among young patients with dry eye disease (DED) and compare them with those of older patients.
Hsin-Yu Weng, Wei-Ting Ho, Chiung-Yi Chiu, Tzu-Yun Tsai, Shu-Wen Chang   +4 more
doaj   +1 more source

Ocular Manifestations of Metabolic Syndrome: A Systemic Vascular Phenotype

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Context Metabolic syndrome (MetS) is defined by central obesity, insulin resistance, hypertension and dyslipidemia. MetS affects over one‐third of US adults. Beyond its cardiovascular burden, MetS has clinically relevant associations with ocular health and may contribute to a systemic vascular and neuro‐metabolic phenotype involving the retina,
Ron T. Varghese, Ansu A. John
wiley   +1 more source

Morphological and functional characteristics of the meibomian gland in pediatric patients with epiblepharon

BMC Ophthalmology
Background To observe morphologic and functional changes in meibomian glands in pediatric patients with and without lower eyelid epiblepharon. Methods In this prospective observation study, 55 eyes of 55 patients( 24 males, 31 females; mean age ± SD,9.82 
Junping Li, Xiaolin Qin, Hong Jiang, Yunan Guo, Xin Liu, Rui Zhang, Lu Jiang, Anshi Du   +7 more
doaj   +1 more source

Renewal of the Holocrine Meibomian Glands by Label-Retaining, Unipotent Epithelial Progenitors

Stem Cell Reports, 2016
The meibomian and sebaceous glands secrete lipids to prevent desiccation of the ocular surface and skin, respectively. Precisely how these holocrine tissues regenerate is not well understood.
Geraint J. Parfitt, Phillip N. Lewis, Robert D. Young, Alex Richardson, J. Guy Lyons, Nick Di Girolamo, James V. Jester   +6 more
doaj   +1 more source

Clinical outcomes of lateral ear canal resection performed in routine clinical practice for chronic otitis externa in dogs: a retrospective descriptive study of 58 ears (2016‐2025)

Journal of Small Animal Practice, EarlyView.
Objectives To retrospectively evaluate the long‐term clinical outcomes of lateral ear canal resection performed as part of routine clinical practice for chronic otitis externa in dogs, and to re‐evaluate the practical utility of lateral ear canal resection from the perspective of contemporary treatment goals emphasising long‐term maintenance of a ...
K. Kiriki, A. Yabuzoe, K. Iyori
wiley   +1 more source

Assessment of meibomian glands using a custom–made meibographer in dry eye patients in Ghana

BMC Ophthalmology, 2018
Background Meibomian Gland Dysfunction (MGD) is a leading cause of evaporative Dry Eye Disease (DED). This makes non-invasive meibography an important procedure in the clinical evaluation of DED patients.
Eugene Appenteng Osae, Reynolds Kwame Ablorddepey, Jens Horstmann, David Ben Kumah, Philipp Steven   +4 more
doaj   +1 more source