Results 41 to 50 of about 5,318 (180)

Congenital aniridia: European COST action ANIRIDIA‐NET guidelines for diagnosis, management and care

Acta Ophthalmologica, Volume 104, Issue 3, Page 267-279, May 2026.
Abstract Congenital aniridia is a rare ocular disorder affecting the majority of eye structures and can be associated with systemic manifestations. The main visible phenotypic characteristic is the partial or complete absence of the iris; however, foveal hypoplasia is a more frequent and reliable clinical sign. Other ocular comorbidities are associated
Davide Romano, Vito Romano, Alejandra Daruich, Giulio Ferrari, Matthieu Robert, Francesco Semeraro, Neil Lagali, Dominique Bremond‐Gignac, the ANIRIDIA‐NET Clinical Guidelines Working Group, Miriam Barbany, Claus Cursiefen, Stefano Ferrari, Francisco Figueiredo, Christina Grupcheva, Jesper Hjortdal, Elke Kreps, Erlend Landsend, Laura Mauring, Hilde Pedersen, Nora Szentmáry, Bogumil Wowra, the Aniridia‐Europa and Geniris Working Group, Sophie Valleix, Juan Álvarez de Toledo, James Lauderdale, Tor Paaske Utheim, Paolo Rama   +26 more
wiley   +1 more source

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, Volume 183, Issue 9, Page 1779-1813, May 2026.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy   +16 more
wiley   +1 more source

Substrate for Thyroid Hormone Synthesis: Biochemistry, Evolution, and Physiology

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
Two proposed sequence of events for thyroxine formation in patients expressing mutant thyroglobulin. (A) (1) TSH stimulation drives expression of misfolded TG. (2) Unremitting ER stress. (3) Stress‐induced cell death. (4) Dead thyrocytes release their contents. (5) The contents become iodinated. (6) Forming thyroxine.
Crystal Young, Peter Arvan
wiley   +1 more source

The 2D:4D Digit Ratio and Primary Sjögren's Syndrome: A Window Into Prenatal Hormonal Influences on Exocrine Autoimmunity

American Journal of Human Biology, Volume 38, Issue 4, April 2026.
ABSTRACT Objectives The pronounced female preponderance in Sjögren's syndrome (SS) points to a potential role for sex hormones in disease development. The ratio of the second to fourth digit (2D:4D), which serves as an indirect marker of fetal androgen exposure, has shown associations with several immune‐mediated conditions.
Mustafa Gür, Ramazan Fazil Akkoc, Burak Oz, Ahmet Karatas, Süleyman Serdar Koca   +4 more
wiley   +1 more source

Pathology and pathogenesis of bovine skin and meibomian gland demodicosis

Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 2015
A national survey on bovine demodicosis was conducted among 48,000 cattle in Sudan during vaccination campaigns (44,800), and at antemortem and postmortem examination in abattoirs (3200).
M. T. Abu-Samra, Y. A. Shuaib
doaj   +1 more source

Brain Involvement in Leishmaniasis

Cell Biochemistry and Function, Volume 44, Issue 4, April 2026.
ABSTRACT Leishmaniasis is a neglected tropical disease caused by infection with the protozoan parasite Leishmania and it is a significant global health problem. The disease has a wide clinical spectrum, from tegumentary leishmaniasis (TL) that encompasses cutaneous (CL), mucosal (ML) and cutaneous‐diffuse (CDL) forms, to the potentially fatal systemic ...
Camila S. Freitas, Eduardo A. F. Coelho, Myron Christodoulides   +2 more
wiley   +1 more source

Prevalence, Etiology, and Antifungal Resistance Profiles of Ocular Fungal Infections in Ghanaian Ophthalmic Patients: A Multicenter Cross‐Sectional Study

Health Science Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background and Aims Ocular fungal infections are an important but often underrecognized cause of ocular morbidity, particularly in resource‐limited settings. Delayed diagnosis and inappropriate treatment can lead to poor visual outcomes and increased disease burden.
Isaiah Osei Duah Junior, Abigail Oforiwaa Boateng, Kwadwo Owusu Akuffo, Lord Gyimah, Kingsley Badu   +4 more
wiley   +1 more source

Meibomian gland dysfunction. III. Meibomian gland lipids.

Investigative ophthalmology & visual science, 1989
The lipid components of meibomian gland excreta were evaluated in rabbits after they received 2% topical epinephrine dropped into their eyes daily for a period of 6 months to a year to induce meibomian gland dysfunction (MGD). Changes were compared to excreta obtained from seven age-matched, untreated control rabbits.
N, Nicolaides, E C, Santos, R E, Smith, J V, Jester   +3 more
openaire   +1 more source

An Attempt to Establish the Consensus Regarding the Diagnosis, Classification, and Treatment of Rosacea in Japan Using a Modified Delphi Method: The Japan Rosacea Consensus

The Journal of Dermatology, Volume 53, Issue 4, Page 605-618, April 2026.
ABSTRACT In Japan, rosacea has attracted increasing interest. However, because rosacea had been thought to be relatively rare in Japan, the perception of this disease varies among dermatologists. To address these challenges, this study developed a consensus regarding the diagnosis, classification, and treatment of rosacea using a modified Delphi method
Kenshi Yamasaki, Nobukazu Hayashi, Hiroaki Hayashi, Yasuko Fukuya, Yuki Horiuchi, Miwa Kobayashi, Yoshimasa Nobeyama, Jun Omatsu, Kanako Tsunoda, Yoshiki Miyachi   +9 more
wiley   +1 more source

Discovery of a novel thiophene carboxamide analogue as a highly potent and selective sphingomyelin synthase 2 inhibitor for dry eye disease therapy

Acta Pharmaceutica Sinica B
Dry eye disease (DED) is a prevalent and intractable ocular disease induced by a variety of causes. Elevated sphingomyelin (SM) levels and pro-inflammatory cytokines were detected on the ocular surface of DED patients, particularly in the meibomian ...
Jintong Yang, Yiteng Lu, Kexin Hu, Xinchen Zhang, Wei Wang, Deyong Ye, Mingguang Mo, Xin Xiao, Xichen Wan, Yuqing Wu, Shuxian Zhang, He Huang, Zhibei Qu, Yimin Hu, Yu Cao, Jiaxu Hong, Lu Zhou   +16 more
doaj   +1 more source