Results 71 to 80 of about 108,509 (215)

Short‐Chain Fatty Acids: Microbial Metabolites Driving Gut‐Eye Axis Signaling

Comprehensive Physiology, Volume 16, Issue 5, October 2026.
Short‐chain fatty acids generated by gut microbial fermentation link diet to ocular physiology via the gut–eye axis. Through systemic distribution, these metabolites regulate GPCR signaling, epigenetic pathways, inflammation, and angiogenesis, shaping retinal homeostasis and highlighting therapeutic potential in ocular vascular and inflammatory ...
Aleah J. Brokemond, Ronny Amamoo, Fapianey J. Alexandre, Sewedo B. Ajisegiri, Menaka C. Thounaojam, Pamela M. Martin, Ravirajsinh N. Jadeja   +6 more
wiley   +1 more source

Gastrointestinal Microbiome Dysbiosis in Cancer Development: Mechanisms and Biomarker Potential

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
Dysbiosis of the gastrointestinal microbiome plays a role in carcinogenesis by inducing chronic inflammation, DNA damage, and activation of signaling pathways such as NF‐κB, STAT3, and Wnt/β‐catenin. Microorganisms such as Helicobacter pylori, Fusobacterium nucleatum, and Bacteroides fragilis promote the development of gastrointestinal tumors through ...
Negar Asgari, Mehrasa Asghari, Touraj Farazmandfar   +2 more
wiley   +1 more source

Hyaluronan in Ocular Surface Health and Disease: From Biological Mechanisms to Therapeutic Applications

Proteoglycan Research, Volume 4, Issue 4, October 2026.
ABSTRACT Hyaluronan (HA) is an ubiquitous non‐sulfated glycosaminoglycan with unique physicochemical and biological properties that underpin its essential roles in tissue homeostasis, repair, and diseases. First identified in the vitreous humor of the eye, HA has a long‐standing history in ophthalmology as a key component of ophthalmic visco‐surgical ...
Sudhir Verma, Mohammed Salman, Eduardo Cilli, Vivien Coulson‐Thomas   +3 more
wiley   +1 more source

Pathology and pathogenesis of bovine skin and meibomian gland demodicosis

Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 2015
A national survey on bovine demodicosis was conducted among 48,000 cattle in Sudan during vaccination campaigns (44,800), and at antemortem and postmortem examination in abattoirs (3200).
M. T. Abu-Samra, Y. A. Shuaib
doaj   +1 more source

Clinical outcomes of lateral ear canal resection performed in routine clinical practice for chronic otitis externa in dogs: a retrospective descriptive study of 58 ears (2016‐2025)

Journal of Small Animal Practice, Volume 67, Issue 10, Page 1032-1044, October 2026.
Objectives To retrospectively evaluate the long‐term clinical outcomes of lateral ear canal resection performed as part of routine clinical practice for chronic otitis externa in dogs, and to re‐evaluate the practical utility of lateral ear canal resection from the perspective of contemporary treatment goals emphasising long‐term maintenance of a ...
K. Kiriki, A. Yabuzoe, K. Iyori
wiley   +1 more source

Meibomian gland dysfunctions related with ocular surface pathology [PDF]

, 2015
Meibomian Glands are the sebum producting glands located in both, the upper and lower eyelids, in number about 25-30. The secretion forms the external layer of the tear film, which prevents the evaporation of the water from the tear film.
Stănilă, Adriana, Stănilă, D.M.
core   +1 more source

Discovery of a novel thiophene carboxamide analogue as a highly potent and selective sphingomyelin synthase 2 inhibitor for dry eye disease therapy

Acta Pharmaceutica Sinica B
Dry eye disease (DED) is a prevalent and intractable ocular disease induced by a variety of causes. Elevated sphingomyelin (SM) levels and pro-inflammatory cytokines were detected on the ocular surface of DED patients, particularly in the meibomian ...
Jintong Yang, Yiteng Lu, Kexin Hu, Xinchen Zhang, Wei Wang, Deyong Ye, Mingguang Mo, Xin Xiao, Xichen Wan, Yuqing Wu, Shuxian Zhang, He Huang, Zhibei Qu, Yimin Hu, Yu Cao, Jiaxu Hong, Lu Zhou   +16 more
doaj   +1 more source

Applications of Machine Learning in Noninvasive Anemia Diagnosis: A Systematic Review Based on Cross‐Industry Standard Process for Data Mining

Health Science Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background and Aims Anemia is a disorder caused by insufficient red blood cell count or hemoglobin concentration, affecting nearly a quarter of the global population each year. An undiagnosed condition can escalate into life‐threatening complications, particularly among pregnant women and children. Although anemia causes identifiable symptoms,
Mohammad Hadi Ghahroudi, Niloofar Mohammadzadeh, Hadiseh Ghadiri Bidhendi   +2 more
wiley   +1 more source

DAMPs, PAMPs, and Alarmins: From Mechanism to Therapy

MedComm, Volume 7, Issue 9, September 2026.
This review synthesizes the expanding biology of PAMPs and DAMPs, from their molecular sources and sensing mechanisms to regulatory networks that govern inflammation and homeostasis. Spanning from classical immune activation to trained immunity and interorgan communication, we highlight the interplay between PAMPs and DAMPs and their context‐dependent ...
Xuanxuan Yu, Yuqin Jin, Baochao Li, Jie Deng, Yiwen Zhou, Jinglun Zhang, Huang Li   +6 more
wiley   +1 more source

Identification of meibomian gland testosterone metabolites produced by tissue-intrinsic intracrine deactivation activity

iScience
Summary: Intracrinology—wherein hormones are synthesized in the organ where they exert their effect without release into circulation—has been described.
Khanh Tien Nguyen Pham, Takahito Miyake, Tomo Suzuki, Shigeru Kinoshita, Yuki Hamada, Hikari Uehara, Mamiko Machida, Takeshi Nakajima, Emi Hasegawa, Masao Doi   +9 more
doaj   +1 more source