Results 71 to 80 of about 96,653 (166)

Discovery of a novel thiophene carboxamide analogue as a highly potent and selective sphingomyelin synthase 2 inhibitor for dry eye disease therapy

open access: yesActa Pharmaceutica Sinica B
Dry eye disease (DED) is a prevalent and intractable ocular disease induced by a variety of causes. Elevated sphingomyelin (SM) levels and pro-inflammatory cytokines were detected on the ocular surface of DED patients, particularly in the meibomian ...
Jintong Yang   +16 more
doaj   +1 more source

Meibomian gland scores of the upper and lower eyelid.

open access: yes, 2023
Grade 0: No loss of Meibomian glands; Grade 1: Loss of Meibomian glands less than one third of the total density on the eyelid; Grade 2: Loss between one and two thirds of the total density of the glands on the eyelid; Grade 3: Loss of glands is greater ...
Amr Saad (5955308)   +3 more
core   +1 more source

Relationship between morphological changes in meibomian glands, age, and ocular surface parameters

open access: yesBMC Ophthalmology
Objective To investigate the relationship of changes in the meibomian glands as visualized through meibography with demographic characteristics and ocular surface parameters. Methods This prospective study included a total of 155 participants.
Eyup Erkan   +5 more
doaj   +1 more source

A clinical study of thunder-fire moxibustion combined with meibomian gland massage in treatment of meibomian gand dysfunction

open access: yes针刺研究, 2022
Objective To observe the effect of thunder-fire moxibustion combined with meibomian gland massage in improving meibomian gland dysfunction(MGD) and explore its mechanism.
QIAN Li-jun   +3 more
doaj  

A clinical utility assessment of the automatic measurement method of the quality of Meibomian glands

open access: yesBioMedical Engineering OnLine, 2017
Background Meibomian gland dysfunction (MGD) is one of the most common diseases observed in clinics and is the leading cause of evaporative dry eye. Today, diagnostics of MGD is not fully automatic yet and is based on a qualitative assessment made by an ...
Robert Koprowski   +2 more
doaj   +1 more source

Randomized comparison of lipid‐containing and non‐lipid‐containing artificial tears on tear film dynamics over a 3‐month period

open access: yesOptometry and Vision Science, Volume 103, Issue 7, July 2026.
ABSTRACT Purpose To study the effects of a lipid‐containing artificial tear (AT) and a non‐lipid‐containing AT on tear film dynamics over a 3‐month period. Methods Subjects with low lipid layer thickness were randomized to lipid‐containing or non‐lipid‐containing ATs for 3 months.
Jennifer E. Ding   +11 more
wiley   +1 more source

Identification of meibomian gland testosterone metabolites produced by tissue-intrinsic intracrine deactivation activity

open access: yesiScience
Summary: Intracrinology—wherein hormones are synthesized in the organ where they exert their effect without release into circulation—has been described.
Khanh Tien Nguyen Pham   +9 more
doaj   +1 more source

Phospholipids in Meibomian Gland Secretion

open access: yesOphthalmic Research, 2009
The bulk of the lipid layer overlying the aqueous portion of the precorneal tear film is composed of polar and nonpolar components. The nonpolar lipids have been the subject of numerous studies; however, the polar lipids have remained relatively uncharacterized.
J V, Greiner   +4 more
openaire   +2 more sources

Quantum Dots in Ocular Surface: A Systematic Review

open access: yesWIREs Nanomedicine and Nanobiotechnology, Volume 18, Issue 4, July/August 2026.
Graphical abstract illustrating the types of QDs, their surface functionalization, diagnostic and therapeutic potential for ocular surface applications. This review highlights advances in QD‐based imaging of the tear film, conjunctiva, and cornea, emphasizing the role of biocompatible QDs in targeting inflammation, oxidative stress, and microbial ...
Sidra Sarwat   +3 more
wiley   +1 more source

Molecular Basis and Clinical Spectrum of WNT10A‐Related Oligodontia

open access: yesClinical Genetics, Volume 110, Issue 1, Page 3-14, July 2026.
Cellular Mechanism behind WNT10A phenotypes. ABSTRACT WNT10A mutations, a major genetic determinant of dental agenesis and ectodermal dysplasia, exert profound effects on craniofacial development. Although classified as rare disorders, these mutations account for more than half of oligodontia cases, reflecting their critical role.
Perennes Elise   +5 more
wiley   +1 more source

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