Results 81 to 90 of about 108,509 (215)

A clinical utility assessment of the automatic measurement method of the quality of Meibomian glands

BioMedical Engineering OnLine, 2017
Background Meibomian gland dysfunction (MGD) is one of the most common diseases observed in clinics and is the leading cause of evaporative dry eye. Today, diagnostics of MGD is not fully automatic yet and is based on a qualitative assessment made by an ...
Robert Koprowski, Lei Tian, Paweł Olczyk   +2 more
doaj   +1 more source

Demodex Infestation in Patients With Atopic Dermatitis Treated With Dupilumab: A Case–Control Study

The Journal of Dermatology, Volume 53, Issue 9, Page 1261-1266, September 2026.
ABSTRACT Atopic dermatitis (AD) is a chronic inflammatory skin disease in which dupilumab, an interleukin‐4 receptor alpha antagonist, has become a cornerstone therapy for moderate‐to‐severe disease. However, persistent facial and neck erythema and related symptoms have been increasingly reported during dupilumab treatment, and the underlying ...
Pinar Dursun, Ayse Nur Saribas Yildirim, Ayca Yazici   +2 more
wiley   +1 more source

What is the incidence and clinical significance of dry eye disease in patients treated with immune checkpoint inhibitors? A systematic review and meta‐analysis of ocular immune‐related adverse events

Acta Ophthalmologica, Volume 104, Issue 6, Page e599-e614, September 2026.
Abstract Purpose Immune checkpoint inhibitors (ICIs) have transformed cancer therapy but may cause immune‐related adverse events (irAEs), including dry eye disease (DED). This study aimed to quantify the incidence of ICI‐associated DED and to evaluate factors contributing to variability across studies.
Kai‐Yang Chen, Hoi‐Chun Chan, Chi‐Ming Chan   +2 more
wiley   +1 more source

Ocular surface alkali injury damages meibomian glands in mice [PDF]

, 2017
PurposeTo examine effects of alkali injury of the ocular surface on meibomian gland pathology in mice.MethodsThree μL of 1 N NaOH were applied under general anesthesia to the right eye of 10-week-old BALB/c (n = 54) mice to produce a total
Yamanaka, Osamu, Geraint J. Parfitt, Shirakawa, Rika, Arita, Reiko, Sumioka, Takayoshi, Osamu Yamanaka, Saika, Shizuya, Yilu Xie, Okada, Yuka, Mizoguchi, Shin, James V. Jester, Kokado, Masahide, Iwanishi, Hiroki, Parfitt, Geraint J, Shizuya Saika, Shin Mizoguchi, Hiroki Iwanishi, Rika Shirakawa, Xie, Yilu, Yuka Okada, Reiko Arita, Masahide Kokado, Takayoshi Sumioka, Jester, James V   +23 more
core   +1 more source

Identification of Meibomian gland stem cell populations and mechanisms of aging

Nature Communications
Meibomian glands secrete lipid-rich meibum, which prevents tear evaporation. Aging-related Meibomian gland shrinkage may result in part from stem cell exhaustion and is associated with evaporative dry eye disease, a common condition lacking effective ...
Xuming Zhu, Mingang Xu, Celine Portal, Yvonne Lin, Alyssa Ferdinand, Tien Peng, Edward E. Morrisey, Andrzej A. Dlugosz, Joseph M. Castellano, Vivian Lee, John T. Seykora, Sunny Y. Wong, Carlo Iomini, Sarah E. Millar   +13 more
doaj   +1 more source

Retrospective Analysis of Survival and Adverse Effects Associated With Stereotactic Body Radiation Therapy in 12 Dogs With Hepatocellular Carcinoma

Veterinary and Comparative Oncology, Volume 24, Issue 3, Page 485-498, September 2026.
ABSTRACT This retrospective analysis evaluated 12 dogs with hepatocellular carcinoma (HCC) who received stereotactic body radiation therapy (SBRT). Dogs received between 6 and 25 Grey (Gy) per fraction for 1–5 fractions for a total dose of 13–30 Gy. Eleven patients (92%) experienced acute adverse effects (AE), with the majority being VRTOG grade 2–3 ...
Victoria Lee Newberry, Mary‐Keara Boss, Del Leary, Tiffany W. Martin   +3 more
wiley   +1 more source

Meibomian gland dysfunction. III. Meibomian gland lipids.

Investigative ophthalmology & visual science, 1989
The lipid components of meibomian gland excreta were evaluated in rabbits after they received 2% topical epinephrine dropped into their eyes daily for a period of 6 months to a year to induce meibomian gland dysfunction (MGD). Changes were compared to excreta obtained from seven age-matched, untreated control rabbits.
N, Nicolaides, E C, Santos, R E, Smith, J V, Jester   +3 more
openaire   +1 more source

Phospholipids in Meibomian Gland Secretion

Ophthalmic Research, 2009
The bulk of the lipid layer overlying the aqueous portion of the precorneal tear film is composed of polar and nonpolar components. The nonpolar lipids have been the subject of numerous studies; however, the polar lipids have remained relatively uncharacterized.
J V, Greiner, T, Glonek, D R, Korb, R, Booth, C D, Leahy   +4 more
openaire   +2 more sources

The 3D meibomian gland of subject C (67 years old, male) with severe MGD (meiboscore grade 3).

, 2013
A: The 3D images showed a few meibomian glands with a normal grape-like pattern. We could not find definite acini attached to the central ducts. B: These findings are consistent with the noncontact infrared meibography, which showed nearly complete loss ...
Jun Geun Shin (424800), Choun-Ki Joo (424803), Tae Joong Eom (424802), Ho Sik Hwang (424799), Byeong Ha Lee (424801)   +4 more
core   +1 more source

Alpha 2u-globulin in modified sebaceous glands with pheromonal functions: localization of the protein and its mRNA in preputial, meibomian, and perianal glands.

, 1989
alpha 2u-Globulin, the principal urinary protein of the male rat, has extensive sequence homology with many lipid binding proteins. The highest concentration of alpha 2u-globulin is found in the preputial gland, a holocrine secretory organ with ...
A K Roy, M A Mancini, B Chatterjee, D Majumdar   +3 more
core   +1 more source