Results 91 to 100 of about 2,542 (193)

Durability of the TearCare treatment effect in subjects with dry eye disease: Stage 3 of the Sahara randomized controlled trial

Optometry and Vision Science, Volume 102, Issue 8, Page 495-504, August 2025.
SIGNIFICANCE: Localized heat therapy with manual expression has been effective for meibomian gland dysfunction‐associated dry eye disease in clinical studies including two randomized controlled trials, and in the present report, provides long‐lasting relief from signs and symptoms for moderate‐to‐severe dry eye disease associated with meibomian gland ...
John Hovanesian, Brandon D. Ayres, Marc R. Bloomenstein, Jennifer Loh, Thomas Chester, Bobby Saenz, Julio Echegoyen, Shane R. Kannarr, Tomasita C. Rodriguez, Jaime E. Dickerson Jr.   +9 more
wiley   +1 more source

Identification of phospholipids in human meibum by nano-electrospray ionisation tandem mass spectrometry

, 2011
Meibum is believed to be the major source of tear !lm lipids, which are vital in the prevention of excessevaporation of the aqueous phase. The complete lipid composition of meibum has yet to be established.While earlier studies reported the presence of ...
Manjula A Ariyavidana (20244843), Jennifer Saville (20116953), Mark DP Willcox (12219888), Zhenjun Zhao (2576056), Stephen Blanksby (20120385), Todd Mitchell (19585504)   +5 more
core  

Can the choice of artificial tears harm patients? A narrative review with an overview of the Nordic market

Acta Ophthalmologica, Volume 103, Issue 5, Page 586-608, August 2025.
Abstract Purpose To provide an overview of artificial tears marketed in the following Nordic countries: Denmark, Finland, Norway, Iceland and Sweden. Furthermore, this review aimed to highlight the different preservatives and other constituents found in artificial tears in the Nordic market, focussing on adverse effects.
K. N. Mikha, C. E. Ø. Rasmussen, S. N. G. Ahrensberg, J. Freiberg, R. A. Wozniak, U. M. K. Alnoor, F. Fineide, T. P. Utheim, S. Heegaard, M. Kolko   +9 more
wiley   +1 more source

Identification of meibomian gland testosterone metabolites produced by tissue-intrinsic intracrine deactivation activity

iScience
Summary: Intracrinology—wherein hormones are synthesized in the organ where they exert their effect without release into circulation—has been described.
Khanh Tien Nguyen Pham, Takahito Miyake, Tomo Suzuki, Shigeru Kinoshita, Yuki Hamada, Hikari Uehara, Mamiko Machida, Takeshi Nakajima, Emi Hasegawa, Masao Doi   +9 more
doaj   +1 more source

Interactions of Meibum and Tears with Mucomimetic Polymers: A Hint towards the Interplay between the Layers of the Tear Film

, 2021
Recent clinical findings suggest that mucomimetic polymers (MMP) can alter not only the texture of the aqueous tear but also the spreading and structure of the tear film (TF) lipid layer, thereby allowing for their synchronized performance in vivo. Thus,
Petar Eftimov, Norihiko Yokoi, Ana M. Melo, Georgi As. Georgiev, Philippe Daull   +4 more
core   +1 more source

Ocular surface changes in moderate-to-severe acne vulgaris [PDF]

International Journal of Ophthalmology
AIM: To investigate ocular surface disorders and tear function changes in patients with acne vulgaris and explore the potential relationship between acne vulgaris and dry eye.
Ci-Yi Pan, Dong-Jie Sun, Han-Ling Li, Li Ma, Min Zhang, Song-Yuan Tang, Hui Zhang   +6 more
doaj   +1 more source

The role of trace elements in the pathogenesis of ocular surface diseases in type 2 diabetes mellitus: current concepts and clinical perspectives

Сахарный диабет
Type 2 diabetes mellitus (T2DM) represents a significant risk factor for the development of ocular surface pathology, with the prevalence of dry eye syndrome, meibomian gland dysfunction, and chronic blepharitis exceeding that in the general population ...
T. N. Safonova, G. V. Zaytseva
doaj   +1 more source

Expression Profiling of Nonpolar Lipids in Meibum From Patients With Dry Eye: A Pilot Study

, 2020
PURPOSE. The purpose of this investigation was to characterize differentially expressed lipids in meibum samples from patients with dry eye disease (DED) in order to better understand the underlying pathologic mechanisms. METHODS.
Kari B Green, Kelly K Nichols, Jianzhong Chen, Jeremy K Keirsey   +3 more
core  

High Resolution Images of Human Meibum Spread on Saline

Investigative Ophthalmology & Visual Science
Understanding of the role of the tear film lipid layer (TFLL) in evaporative dry eye requires knowledge of its structure. X-ray studies show 11.1-nm thick lamellae in meibum at tear film temperature (approximately 35°C), whereas below 30°C, 4.88-nm thick lamellae predominate.
King-Smith, P. Ewen, Begley, Carolyn G., Braun, Richard J.   +2 more
openaire   +2 more sources

Cholesteryl esters as a depot for very long chain fatty acids in human meibum*

Journal of Lipid Research, 2009
Human meibomian gland secretions (also known as meibum) were analyzed for the presence of cholesteryl esters (Chl-E) using HPLC in combination with atmospheric pressure chemical ionization mass spectrometry.
Igor A. Butovich
doaj   +1 more source