Results 161 to 170 of about 2,542 (193)
Insights Into Tear Film Stability From Babies and Young Adults: A Study of Human Meibum Lipid Conformation and Rheology [PDF]
International Journal of Molecular Sciences, 2018 Babies have the most stable tears and people with dry eye have the least stable tears. Meibum may contribute to tear film stability, so in this study, the hydrocarbon chain conformation and rheology of meibum from babies was studied for the first time ...
Poonam Mudgil +2 more
exaly +2 more sources
Modeling Meibum Secretion: Alternatives for Obstructive Meibomian Gland Dysfunction (MGD) [PDF]
Ocular SurfacePURPOSE: While changes in meibum quality are correlated with severity of meibomian gland dysfunction (MGD) and dry eye disease, little is known regarding the mechanics of meibum secretion.
James Jester +2 more
exaly +2 more sources
Characterization of Expressed Human Meibum Using Hyperspectral Stimulated Raman Scattering Microscopy [PDF]
Ocular Surface, 2019 PURPOSE: This study examined whether hyperspectral stimulated Raman scattering (hsSRS) microscopy can detect differences in meibum lipid to protein composition of normal and evaporative dry eye subjects with meibomian gland dysfunction. METHODS: Subjects
Sam Garg +2 more
exaly +2 more sources
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Historical Brief on Composition of Human Meibum Lipids
Ocular Surface, 2009Meibomian glands (MG) secrete an oily substance, meibum, that spreads across the ocular surface and mixes with secretions produced by other ocular structures to create a thin film. The protective efficacy of the tear film is believed to be related to the chemical composition of the lipid layer.
Jadwiga C Wojtowicz, James P McCulley
exaly +3 more sources
Association of Meibum Oleic Acid with Meibomian Seborrhea
Cornea, 2000We sought to determine whether patient meibum fatty acid unsaturation is associated with meibomian gland secretion consistency.Meibomian gland secretions were dissolved in chloroform and separated into lipid classes by thin-layer chromatography. Fatty acids in individual lipid classes were characterized by gas chromatography after transmethylation ...
W E, Shine, J P, McCulley
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Characterization of Human Meibum Lipid Using Raman Spectroscopy
Current Eye Research, 2009Raman spectroscopy could potentially be used as a diagnostic tool for the detection of meibomian gland dysfunction by measuring the composition, conformation, and amount of meibum lipid on the lid margin. Toward this goal and to test our studies of meibum lipid using infrared spectroscopy, we measured the Raman spectra of samples from human donors with
Yusuke Oshima +2 more
exaly +3 more sources
Molecular Structure of Interfacial Human Meibum Films
Langmuir, 2012Meibum is the primary component of the tear film lipid layer. Thought to play a role in tear film stabilization, understanding the physical properties of meibum and how they change with disease will be valuable in identifying dry eye treatment targets.
Danielle L, Leiske +14 more
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The Presence and Significance of Polar Meibum and Tear Lipids
The Ocular Surface, 2015The ocular tear film is a complex structure composed of a number of elements. While all of these components serve valuable functional and structural roles, the external lipid layer has been a focus because it is known to play a critical role in dry eye.
Andrew D, Pucker, Kristina M, Haworth
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Meibum lipid composition in type 2 diabetics with dry eye
Experimental Eye Research, 2021The purpose of this investigation was to analyze and compare the composition of meibum between type 2 diabetics with dry eye disease (DED) and control subjects to better reveal the pathologic mechanisms of the meibomian gland degeneration (MGD) and DED in type 2 diabetes mellitus (T2DM).90 subjects were divided into the following 4 groups: DM-DED group:
Qin Yang, Bing Li, Minjie Sheng
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Physical Changes in Human Meibum With Age as Measured by Infrared Spectroscopy [PDF]
Ophthalmic Research, 2010 Both lipids and mucins contribute to the stability of the tear film and lipids may inhibit tears from evaporating. Younger people have lower lipid viscosity, higher lipid volume, and a lower rate of tear evaporation. Since age-related changes in human meibum composition and conformation have never been investigated, as a basis for the study of lipid ...
Douglas Borchman +2 more
exaly +3 more sources