Results 121 to 130 of about 111,170 (357)

DNA strand exchange and RecA homologs in meiosis.

open access: yesCold Spring Harbor Perspectives in Biology, 2014
Homology search and DNA strand-exchange reactions are central to homologous recombination in meiosis. During meiosis, these processes are regulated such that the probability of choosing a homolog chromatid as recombination partner is enhanced relative to
M. Brown, D. K. Bishop
semanticscholar   +1 more source

From One Strand Dyed/Undyed Hair With/Without Root to Fast and Successful STR Profiling and Evaluation With Principle Component Analysis

open access: yesELECTROPHORESIS, EarlyView.
ABSTRACT Fallen/shed single hair shafts with/without roots can be encountered as evidence in crime scenes. Identification from hair exhibits serious difficulties, due to the low amount of DNA, PCR inhibitors, and the existence of DNA mostly in degraded forms. Exposure of hair to chemical oxidation, sunlight, etc.
Gulten Rayimoglu   +2 more
wiley   +1 more source

Spatial single-cell sequencing of meiosis I arrested oocytes indicates acquisition of maternal transcripts from the soma

open access: yesCell Reports, 2023
Summary: Maternal RNAs are stored from minutes to decades in oocytes throughout meiosis I arrest in a transcriptionally quiescent state. Recent reports, however, propose a role for nascent transcription in arrested oocytes.
Kenneth A. Trimmer   +6 more
doaj  

Meiosis-specific cohesin mediates homolog recognition in mouse spermatocytes

open access: yesGenes & Development, 2014
How homologous chromosomes recognize each other during meiosis remains a fundamental question in chromosome biology. Ishiguro et al. now show that homolog recognition in spermatocytes starts in early meiotic prophase.
K. Ishiguro   +11 more
semanticscholar   +1 more source

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

open access: yesEnvironmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons   +17 more
wiley   +1 more source

Retinoic Acid Activates Two Pathways Required for Meiosis in Mice

open access: yesPLoS Genetics, 2014
In all sexually reproducing organisms, cells of the germ line must transition from mitosis to meiosis. In mice, retinoic acid (RA), the extrinsic signal for meiotic initiation, activates transcription of Stra8, which is required for meiotic DNA ...
J. Koubová   +8 more
semanticscholar   +1 more source

An investigation into the transcription factors and regulatory mechanisms of Aspergillus

open access: yesFood Safety and Health, EarlyView.
Foodborne pathogen Aspergillus, a prevalent etiologic agent among filamentous fungi, are distinguished by a significant repertoire of transcription factors encoded within their genomes. These regulatory proteins are instrumental in orchestrating key biological processes, including cellular growth, secondary metabolite biosynthesis, mycotoxin production,
Yuxin Qin, Huawei Yu, Jun Tian
wiley   +1 more source

The mitochondrial DNA copy number and ovary‐related reproductive disorders: A bidirectional two‐sample Mendelian randomization study

open access: yesInternational Journal of Gynecology &Obstetrics, Volume 169, Issue 1, Page 112-120, April 2025.
Abstract Objective In the present study, a bidirectional two‐sample Mendelian randomization approach was utilized to explore potential causal relationships between mitochondrial DNA copy number (mtDNA‐CN) and ovary‐related reproductive disorders (ORRDs), including ovarian dysfunction, ovarian cyst, polycystic ovary syndrome (PCOS), premature ovarian ...
Ke Peng   +4 more
wiley   +1 more source

Mek1 coordinates meiotic progression with DNA break repair by directly phosphorylating and inhibiting the yeast pachytene exit regulator Ndt80.

open access: yesPLoS Genetics, 2018
Meiotic recombination plays a critical role in sexual reproduction by creating crossovers between homologous chromosomes. These crossovers, along with sister chromatid cohesion, connect homologs to enable proper segregation at Meiosis I. Recombination is
Xiangyu Chen   +7 more
doaj   +1 more source

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