Results 141 to 150 of about 157,342 (355)

FIGO committee opinion: Environmental drivers of obstetric health and early childhood development

open access: yesInternational Journal of Gynecology &Obstetrics, EarlyView.
Abstract Environmental exposures are increasingly recognized as critical, yet underappreciated, determinants of reproductive, perinatal, and early childhood health. Developed through a structured consensus process and grounded in systematic evidence review, this FIGO committee opinion provides a comprehensive synthesis of the current evidence linking ...
Nathaniel DeNicola   +12 more
wiley   +1 more source

Mek1 coordinates meiotic progression with DNA break repair by directly phosphorylating and inhibiting the yeast pachytene exit regulator Ndt80.

open access: yesPLoS Genetics, 2018
Meiotic recombination plays a critical role in sexual reproduction by creating crossovers between homologous chromosomes. These crossovers, along with sister chromatid cohesion, connect homologs to enable proper segregation at Meiosis I. Recombination is
Xiangyu Chen   +7 more
doaj   +1 more source

Temperature and light drive physiological and transcriptional responses, modulating infection outcomes in a freshwater diatom–chytrid system

open access: yesLimnology and Oceanography, EarlyView.
Abstract Stephanodiscus binderanus is a bloom‐forming diatom abundant in winter and persisting into spring in the Laurentian Great Lakes. Climate change impacts these blooms by altering ice cover, turbidity, light penetration, and water temperature.
Katelyn McKindles   +4 more
wiley   +1 more source

Rad51 at the Crossroads: Bridging DNA Repair, Tumorigenesis, and Immune Regulation

open access: yesMed Research, EarlyView.
Therapeutic landscape of Rad51 in cancer treatment. Key elements include (1) DNA damage sources (PARPi, chemo/radiotherapy); (2) repair pathways (Rad51‐mediated HR); (3) intervention strategies (Rad51 inhibitors, CRISPR/Cas9); and (4) combination approaches (immunotherapy). The figure is created with BioRender.com.
Zhendong Qin   +4 more
wiley   +1 more source

Friends or foes? Polyploidy and competition in a grassland geophyte

open access: yesOikos, EarlyView.
Previous studies have suggested polyploids may possess a competitive advantage over diploids, due to their larger size, increased vigour or ability to better respond to abiotic stress. However, few studies have tested the effect of polyploidy on competitive ability directly, and only relatively recently has this oversight begun to be addressed. Here we
Damian Vaz de Sousa   +3 more
wiley   +1 more source

A Prospective Evaluation of the Diagnostic Utility for Low‐Coverage Genome Sequencing in Prenatal Samples: A Comparison With Chromosomal Microarray Analysis

open access: yesPrenatal Diagnosis, EarlyView.
ABSTRACT Objective The present study aimed to evaluate the efficacy of LC‐GS in detecting clinically relevant chromosomal abnormalities in comparison with conventional CMA within a prenatal context. Methods We conducted a prospective study involving 200 amniotic fluid samples.
Yan Yin   +11 more
wiley   +1 more source

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