Results 151 to 160 of about 111,170 (357)
Genetic Determinants of the Familial Hypercholesterolaemia Phenotype
Annals of Human Genetics, EarlyView.ABSTRACT Individuals with familial hypercholesterolaemia (FH) have severely elevated plasma concentrations of low‐density lipoprotein cholesterol (LDL‐C) from birth and as a consequence have an elevated morbidity and mortality due to the development of coronary heart disease (CHD).
Steve Eric Humphries, Marta Futema
wiley +1 more source
Power and Limitations of Inferring Genetic Ancestry
Annals of Human Genetics, EarlyView.ABSTRACT Background The recent emergence of technologies that capture and analyse genetic variation patterns obtained from a person's DNA sample has led to numerous academic and commercial endeavours to infer individuals' ancestries. In theory, a person's genome contains a wealth of readily accessible information regarding their ancestors, despite only
Nancy Bird +2 more
wiley +1 more source
Asia-Pacific Journal of Clinical Oncology, EarlyView.Investigating the diagnostic potential and functional role of CDCA genes in breast cancer. ABSTRACT Background The cell division cycle‐associated (CDCA) genes regulate key cellular processes like cell cycle progression and division. This study evaluates the diagnostic and clinical relevance of CDCA genes in breast cancer.
Yongsheng Zhao, Xiaocha Ma, Jun Zhou
wiley +1 more source
Molecular mechanisms of Eda‐mediated adaptation to freshwater in threespine stickleback
Molecular Ecology, EarlyView., 2023 Abstract A main goal of evolutionary biology is to understand the genetic basis of adaptive evolution. Although the genes that underlie some adaptive phenotypes are now known, the molecular pathways and regulatory mechanisms mediating the phenotypic effects of those genes often remain a black box.
Carlos E. Rodríguez‐Ramírez +5 more
wiley +1 more source
THE EFFECT OF FAST NEUTRONS ON CHROMOSOMES IN MEIOSIS AND ITS BEARING UPON PACHYTENE PAIRING [PDF]
, 1942 Alfred Marshak, W S Malloch
openalex +1 more source
Andrology, EarlyView.Abstract Background Histological analysis of the testicular sections is paramount in infertility research but tedious and often requires months of training and practice. Objectives Establish an expeditious histopathological analysis of mutant mice testicular sections stained with commonly available hematoxylin and eosin (H&E) via enhanced deep learning
Nianfei Ao +11 more
wiley +1 more source
Andrology, EarlyView.Abstract Background Imatinib and dasatinib are tyrosine kinase inhibitors (TKIs) increasingly used to treat several diseases in both children and adults at fertile age. We have previously shown that imatinib has adverse effects on developing testis, and imatinib‐treated male patients have been reported to have reduced sperm counts.
Anna Eggert +10 more
wiley +1 more source
Induction of Chromosome Breakage at Meiosis by a Magnesium Deficiency in Tradescantia
, 1953 Dale M. Steffensen
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EP300‐interacting inhibitor of differentiation 3 is required for spermatogenesis in mice
Andrology, EarlyView.Abstract Background Mammalian spermatogenesis is a highly complex process of cell proliferation, meiosis, and differentiation. A series of genes are expressed in an orderly and precise manner to ensure spermatogenesis, with chromatin undergoing intricate changes throughout.
Ping Zhang +7 more
wiley +1 more source