Results 21 to 30 of about 48,915 (171)
Causal Inference in Genetic Trio Studies [PDF]
Proc. Natl. Acad. Sci. U.S.A. 177 (2020) 24117-24126, 2020 We introduce a method to rigorously draw causal inferences---inferences immune to all possible confounding---from genetic data that include parents and offspring. Causal conclusions are possible with these data because the natural randomness in meiosis can be viewed as a high-dimensional randomized experiment.
arxiv +1 more source
Spermatogenesis: The Commitment to Meiosis.
Physiological Reviews, 2016 Mammalian spermatogenesis requires a stem cell pool, a period of amplification of cell numbers, the completion of reduction division to haploid cells (meiosis), and the morphological transformation of the haploid cells into spermatozoa (spermiogenesis ...
M. Griswold
semanticscholar +1 more source
Recombination, Pairing, and Synapsis of Homologs during Meiosis.
Cold Spring Harbor Perspectives in Biology, 2015 Recombination is a prominent feature of meiosis in which it plays an important role in increasing genetic diversity during inheritance. Additionally, in most organisms, recombination also plays mechanical roles in chromosomal processes, most notably to ...
D. Zickler, N. Kleckner
semanticscholar +1 more source
eLife, 2016 Wapl induces cohesin dissociation from DNA throughout the mitotic cell cycle, modulating sister chromatid cohesion and higher-order chromatin structure.
Oliver Crawley +7 more
doaj +1 more source
Monopolin subunit Csm1 associates with MIND complex to establish monopolar attachment of sister kinetochores at meiosis I. [PDF]
PLoS Genetics, 2013 Sexually reproducing organisms halve their cellular ploidy during gametogenesis by undergoing a specialized form of cell division known as meiosis. During meiosis, a single round of DNA replication is followed by two rounds of nuclear divisions (referred
Sourav Sarkar +6 more
doaj +1 more source
MeiosisOnline: A Manually Curated Database for Tracking and Predicting Genes Associated With Meiosis
Frontiers in Cell and Developmental Biology, 2021 Meiosis, an essential step in gametogenesis, is the key event in sexually reproducing organisms. Thousands of genes have been reported to be involved in meiosis. Therefore, a specialist database is much needed for scientists to know about the function of
Xiaohua Jiang +8 more
doaj +1 more source
Tackling Plant Meiosis: From Model Research to Crop Improvement
Frontiers in Plant Science, 2018 Genetic engineering and traditional plant breeding, which harnesses the natural genetic variation that arises during meiosis, will have key roles to improve crop varieties and thus deliver Food Security in the future. Meiosis, a specialized cell division
Christophe Lambing, Stefan Heckmann
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Co-evolution of the mitotic and meiotic modes of eukaryotic cellular division [PDF]
Physical Review E 98 (2018), 032409, 2018 The genetic material of a eukaryotic cell comprises both nuclear DNA (ncDNA) and mitochondrial DNA (mtDNA). These differ markedly in several aspects but nevertheless must encode proteins that are compatible with one another. Here we introduce a network model of the hypothetical co-evolution of the two most common modes of cellular division for ...
arxiv +1 more source
Cell Reports, 2012 In meiosis, two specialized cell divisions allow the separation of paired chromosomes first, then of sister chromatids. Separase removes the cohesin complex holding sister chromatids together in a stepwise manner from chromosome arms in meiosis I, then ...
Sandra A. Touati +10 more
doaj +1 more source
Dynamic Histone H3 Modifications Regulate Meiosis Initiation via Respiration
Frontiers in Cell and Developmental Biology, 2021 Meiosis is essential for genetic stability and diversity during sexual reproduction in most eukaryotes. Chromatin structure and gene expression are drastically changed during meiosis, and various histone modifications have been reported to participate in
Jian Shi +6 more
doaj +1 more source