Results 41 to 50 of about 188,115 (331)
Apoptosis in mouse fetal and neonatal oocytes during meiotic prophase one [PDF]
, 2007 Background The vast majority of oocytes formed in the fetal ovary do not survive beyond birth. Possible reasons for their loss include the elimination of non-viable genetic constitutions arising through meiosis, however, the ...
Ghafari , Fataneh +2 more
core +4 more sources
The Cyclin B2/CDK1 Complex Conservatively Inhibits Separase Activity in Oocyte Meiosis II
Frontiers in Cell and Developmental Biology, 2021 Recently, we have reported that the cyclin B2/CDK1 complex regulates homologous chromosome segregation through inhibiting separase activity in oocyte meiosis I, which further elucidates the compensation of cyclin B2 on cyclin B1’s function in meiosis I ...
Jian Li +7 more
doaj +1 more source
A Computational Approach to Estimating Nondisjunction Frequency in Saccharomyces cerevisiae. [PDF]
, 2016 Errors segregating homologous chromosomes during meiosis result in aneuploid gametes and are the largest contributing factor to birth defects and spontaneous abortions in humans.
Burgess, Sean M, Chu, Daniel B
core +3 more sources
eLife, 2012 During meiosis, a single round of DNA replication is followed by two consecutive rounds of nuclear divisions called meiosis I and meiosis II. In meiosis I, homologous chromosomes segregate, while sister chromatids remain together.
Matthew P Miller +3 more
doaj +1 more source
The Hop2-Mnd1 Complex and Its Regulation of Homologous Recombination
Biomolecules, 2023 Homologous recombination (HR) is essential for meiosis in most sexually reproducing organisms, where it is induced upon entry into meiotic prophase. Meiotic HR is conducted by the collaborative effort of proteins responsible for DNA double-strand break ...
Hideo Tsubouchi
doaj +1 more source
Nature Communications, 2019 Pairing of homologous chromosomes in meiosis is essential for sexual reproduction. We have previously demonstrated that the fission yeast sme2 RNA, a meiosis-specific long noncoding RNA (lncRNA), accumulates at the sme2 chromosomal loci and mediates ...
Da‐Qiao Ding +8 more
semanticscholar +1 more source
On the origin of trisomy 21 Down syndrome [PDF]
, 2008 Background: Down syndrome, characterized by an extra chromosome 21 is the most common genetic cause for congenital malformations and learning disability.
Hultén, Maj A. +6 more
core +2 more sources
TDM1 Regulation Determines the Number of Meiotic Divisions. [PDF]
PLoS Genetics, 2016 Cell cycle control must be modified at meiosis to allow two divisions to follow a single round of DNA replication, resulting in ploidy reduction. The mechanisms that ensure meiosis termination at the end of the second and not at the end of first division
Marta Cifuentes +12 more
doaj +1 more source
Actin cytoskeleton dynamics in mammalian oocyte meiosis†
Biology of Reproduction, 2018 During mitosis, cells undergo symmetrical cell division, while oocyte meiotic maturation undergoes two consecutive, asymmetric divisions that generate a totipotent haploid oocyte and two small polar bodies not involved in DNA replication.
Xing Duan, Shao‐Chen Sun
semanticscholar +1 more source
Crystal structure of Hop2-Mnd1 and mechanistic insights into its role in meiotic recombination [PDF]
, 2015 In meiotic DNA recombination, the Hop2-Mnd1 complex promotes Dmc1-mediated single-stranded DNA (ssDNA) invasion into homologous chromosomes to form a synaptic complex by a yet-unclear mechanism.
Alexandra-Styliani Kalantzi +66 more
core +3 more sources