Results 71 to 80 of about 188,115 (331)
Evidence that MEK1 positively promotes interhomologue double-strand break repair [PDF]
, 2010 During meiosis there is an imperative to create sufficient crossovers for homologue segregation. This can be achieved during repair of programmed DNA double-strand breaks (DSBs), which are biased towards using a homologue rather than sister chromatid as ...
Bishop-Bailey, A +5 more
core +1 more source
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
The Phosphatase Dusp7 Drives Meiotic Resumption and Chromosome Alignment in Mouse Oocytes
Cell Reports, 2016 Summary: Mammalian oocytes are stored in the ovary, where they are arrested in prophase for prolonged periods. The mechanisms that abrogate the prophase arrest in mammalian oocytes and reinitiate meiosis are not well understood.
Thomas Tischer, Melina Schuh
doaj +1 more source
Advanced Healthcare Materials, EarlyView.Decellularized liver extracellular matrix scaffolds provide a platform to study dormant liver‐metastatic colorectal cancer. They induce reversible dormancy, in combination with nutrient depletion and low dose chemotherapy, through cell cycle arrest and chemotherapy resistance.
Sabrina N. VandenHeuvel +13 more
wiley +1 more source
Two mechanisms repress cyclin B1 translation to maintain prophase arrest in mouse oocytes
Nature CommunicationsIn mammals, oocytes are arrested in prophase of meiosis I for long periods of time. Prophase arrest is critical for reproduction because it allows oocytes to grow to their full size to support meiotic maturation and embryonic development. Prophase arrest
Shiya Cheng, Melina Schuh
doaj +1 more source
Biomolecular Concepts, 2014 Meiosis is a unique type of cell division that is performed only by germ cells to form haploid gametes. The switch from mitosis to meiosis exhibits a distinct sex-specific difference in timing, with female germ cells entering meiosis during fetal ...
Jørgensen Anne, Rajpert-De Meyts Ewa
doaj +1 more source
Anastral spindle assembly and γ-tubulin in
BMC Cell Biology, 2011 Background Anastral spindles assemble by a mechanism that involves microtubule nucleation and growth from chromatin. It is still uncertain whether γ-tubulin, a microtubule nucleator essential for mitotic spindle assembly and maintenance, plays a role ...
Hallen Mark A, Endow Sharyn A
doaj +1 more source
Haploid meiosis in Arabidopsis: double-strand breaks are formed and repaired but without synapsis and crossovers. [PDF]
PLoS ONE, 2013 Two hallmark features of meiosis are i) the formation of crossovers (COs) between homologs and ii) the production of genetically-unique haploid spores that will fuse to restore the somatic ploidy level upon fertilization.
Marta Cifuentes +4 more
doaj +1 more source
Separase Control and Cohesin Cleavage in Oocytes: Should I Stay or Should I Go?
Cells, 2022 The key to gametogenesis is the proper execution of a specialized form of cell division named meiosis. Prior to the meiotic divisions, the recombination of maternal and paternal chromosomes creates new genetic combinations necessary for fitness and ...
Katja Wassmann
doaj +1 more source
The Rice AAA-ATPase OsFIGNL1 Is Essential for Male Meiosis
Frontiers in Plant Science, 2017 Meiosis is crucial in reproduction of plants and ensuring genetic diversity. Although several genes involved in homologous recombination and DNA repair have been reported, their functions in rice (Oryza sativa) male meiosis remain poorly understood. Here,
Peipei P. Zhang +12 more
semanticscholar +1 more source