Results 211 to 220 of about 6,538,014 (290)

Evaluation of Uliginosin B as a Modulator of the Ras Pathway: In Vivo Evidence From Caenorhabditis elegans and In Silico Insights

open access: yesChemistry &Biodiversity, Volume 23, Issue 8, August 2026.
This study performs in vivo and in silico assays with uliginosin B, targeting its activity in the Ras signaling pathway, demonstrating a possible allosteric interaction with the HRAS (human) and LET‐60 (nematode) proteins, and a decrease in the overexpression of the let‐60 gene in the nematode C. elegans.
Maria Eduarda O. De Souza   +9 more
wiley   +1 more source

Neighboring Gulf Killifish (Fundulus grandis) Populations Differ in Their Plastic and Genetic Responses to Salinity Fluctuations

open access: yesEcology and Evolution, Volume 16, Issue 8, August 2026.
Coastal development can alter the salinity fluctuations experienced by tidal creek systems. Understanding how resident organisms, such as the Gulf killifish, respond to these changes is critical, as development along the coastline is projected to triple in the coming decades.
Antrelle D. Clark   +3 more
wiley   +1 more source

Investigation of the Prevalence of the HLA‐B*15:02 Allele in the Asian Populations: A Comprehensive Analysis Through Using AFND

open access: yesHealth Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background and Aims The HLA‐B*15:02 allele is related to a high risk of severe cutaneous adverse drug reactions (SCARs) in patients taking certain antiepileptic drugs. However, its prevalence in the Asian population and the number of drugs linked to SCARs due to the carriage of this variant are relatively underexplored.
Mohitosh Biswas   +3 more
wiley   +1 more source

Baicalin Protects Mouse Testis From Injury Induced by PM2.5 Associated With the DKK1‐Wnt/β‐Catenin Signaling Pathway

open access: yesJournal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
ABSTRACT Fine particulate matter (PM2.5) has a damaging effect on the male reproductive system. Baicalin has excellent anti‐inflammatory and antioxidant pharmacological functions. The main purpose of this study was to investigate whether baicalin had a protective effect against PM2.5‐induced damage to the reproductive system of mice, and to further ...
Lili Deng   +10 more
wiley   +1 more source

Y Chromosome Haplogroups and Susceptibility to Esophageal Squamous Cell Carcinoma: An Exploratory Association and Diagnostic Modeling Study

open access: yesMolecular Genetics &Genomic Medicine, Volume 14, Issue 8, August 2026.
The exploratory study examined whether Y chromosome haplogroups are potentially associated with ESCC in a male Chinese cohort. O2a1b and O1b1a showed nominal differences between patients and controls, but these signals were not robust after FDR correction. RNA‐seq suggested possible biological differences, which require validation in larger independent
Xueji Shi   +7 more
wiley   +1 more source

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