Results 71 to 80 of about 71,718 (296)

NAD+‐Dependent Enzyme SIRT3 Limits Intestinal Epithelial Cell Functions Through NAD+ Synthesis Pathway in Colorectal Cancer

open access: yesAdvanced Science, EarlyView.
Microbiota‐derived quinolinic acid is used as an alternative source of replenishing the intracellular NAD+ pool induced by SIRT3 deficiency to regulate intestinal epithelial cell and T cell function, which has implications for targeting intestinal epithelial cells as an approach to the treatment of immune‐associated diseases, including colorectal ...
Ruiying Niu   +12 more
wiley   +1 more source

Uncoupling Metastasis and Epithelial‐to‐Mesenchymal Transition in sgP19/kRAS‐Driven Spontaneous Metastatic Liver Tumor Model

open access: yesAdvanced Science, EarlyView.
The article first reported that a murine mixed typical intrahepatic cholangiocarcinoma (iCCA)/sarcomatoid iCCA liver tumor model with 100% incidence of spontaneous extrahepatic metastasis and confirmed the occurrence of in mouse iCCA. Most importantly, EMT induced by the TGF‐β/ZEB1 axis does not influence tumor development or distant metastasis in this
Jingwen Wang   +12 more
wiley   +1 more source

Individual- and community-level risk factors for maternal morbidity and mortality among Native American women in the USA: a systematic review

open access: yesBMJ Open
Introduction and objective Maternal morbidity and mortality (MMM) is a public health concern in the USA, with Native American women experiencing higher rates than non-Hispanic White women.
Purnima Madhivanan   +9 more
doaj   +1 more source

Protease‐Activated Plasmonic Nanosensors for Predictive Ultrasound‐Guided Photoacoustic Imaging of Tumor Responses to Adoptive T Cell Therapy

open access: yesAdvanced Science, EarlyView.
Protease‐activated plasmonic nanosensors are demonstrated to noninvasively monitor antitumor T cell activity in tumors with anatomical information upon adoptive T cell transfer via ultrasound‐guided photoacoustic imaging. These nanosensors are actuated by granzyme B, a protease secreted by activated cytotoxic T cells during tumor cell killing, which ...
Myeongsoo Kim   +10 more
wiley   +1 more source

A Wireless, Battery‐Free Artificial Throat Patch with Deep Learning for Emotional Speech Recognition

open access: yesAdvanced Science, EarlyView.
In this work, Xu and co‐workers develop a wireless, battery‐free artificial throat patch system (ATPS) consisting of a carbon nanotube‐based thin‐film strain sensor and a miniaturized flexible printed circuit board, to enable real‐time sensing of throat signals.
Bingxin Xu   +10 more
wiley   +1 more source

Nanoparticle Immunoadjuvant Complexes Augment Germinal Center Responses to Vaccination

open access: yesAdvanced Science, EarlyView.
Scaffolding IL‐21 on the surface of a self‐assembling nanoparticle immunogen drives improved germinal center and humoral immune responses. These nanoparticle immunoadjuvant complexes (NICs) functionally modulate the germinal center driving improved somatic hypermutation and antibody maturation, suggesting this platform has potential utility as a ...
Nicholas J. Tursi   +21 more
wiley   +1 more source

Durable Thin‐Film Porous Transport Electrodes for High Current Density PEM Water Electrolysis

open access: yesAdvanced Science, EarlyView.
Water electrolysis using porous transport electrodes with sputter‐deposited, ionomer‐free thin films of rutile IrO2 catalyst suppresses Ir dissolution by >10x over other forms of IrOx. The rutile IrO2 catalyst prepared by this readily scalable electrode synthesis method provides stable cell operation at 3 A cm−2 while using low Ir loading (0.4 mg Ir cm−
James L. Young   +18 more
wiley   +1 more source

Centering the role of community health workers in social risk screening, referral, and follow-up within the primary care setting

open access: yesBMC Primary Care
Background Community health workers (CHWs) remain an underutilized resource in social risk diagnostics in the primary care setting. This process evaluation study seeks to assess the role of CHWs in social risk screening, referral, and follow-up through ...
Emily K. Larson   +8 more
doaj   +1 more source

Melatonin Sources in Sheep Rumen and Its Role in Reproductive Physiology

open access: yesAnimals
In mammals, the melatonin (Mel) concentration in the gastrointestinal tract is 400 times greater than in the pineal gland. However, the origin of Mel in the gastrointestinal tract and its role in reproductive regulation remains unclear.
Tian Niu   +8 more
doaj   +1 more source

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